Condition (MeSH)
Leukomalacia, Periventricular
ClinicalTrials.gov lists 39 trials for Leukomalacia, Periventricular or a narrower condition beneath it. NICHD Neonatal Research Network has the most among industry and government lead sponsors, with 2.
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Trials per phase
39 of the 39 trials are tagged with Leukomalacia, Periventricular itself; the rest are tagged with a narrower condition beneath it.
When did Leukomalacia, Periventricular trials start? (23)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 4
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 1 |
| 2025 | 2 |
| 2023 | 1 |
| 2022 | 1 |
| 2021 | 2 |
| 2020 | 2 |
| 2019 | 1 |
| 2018 | 1 |
| 2017 | 4 |
| 2016 | 1 |
Showing 10 of 23 earlier years.
No forecast is made for this condition: it averages 1.0 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 1 trial still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Leukomalacia, Periventricular trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 2 |
| Phase 1/2 | 3 |
| Phase 2 | 4 |
| Phase 2/3 | 1 |
| Phase 3 | 7 |
| Phase 4 | 1 |
| Not applicable | 12 |
| Observational | 9 |
How many Leukomalacia, Periventricular trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 1 |
| Recruiting | 2 |
| Enrolling by invitation | 1 |
| Active, not recruiting | 1 |
| Completed | 21 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Leukomalacia, Periventricular trials? (3)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| NICHD Neonatal Research Network | 2 |
| Draeger Medical Systems, Inc. | 1 |
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 1 |
Which drugs are being tested for Leukomalacia, Periventricular? (1)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| EPOETIN ALFA | 2 |
Interventions as named in the registry (14)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Recombinant Human Erythropoietin | 2 |
| Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC-14 | 1 |
| Dextrose 5 | 1 |
| UDI-001 | 1 |
| Progesterone 8% | 1 |
Showing 5 of 14 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Leukomalacia, Periventricular trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Need for Surgical or Catheter-Based Intervention | 87 | 1 |
| Symptomatic patent ductus arteriosis (PDA) | 86 | 1 |
| Pulmonary interstitial emphysema (PIE) | 45 | 1 |
| Necrotizing enterocolitis (NEC) of Bell's stage 2 severity or greater | 33 | 1 |
| Severe IVH/PVL | 29 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Leukomalacia, Periventricular? (83)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Improved Myelination following Camp Leg Power, a Selective Motor Control Intervention for Children with Spastic Bilateral Cerebral Palsy: A Diffusion Tensor MRI Study. | AJNR. American journal of neuroradiology | 2023 | Yes |
| Structural brain damage and visual disorders in children with cerebral palsy due to periventricular leukomalacia. | NeuroImage. Clinical | 2020 | Yes |
| Spastic diplegia in preterm-born children: Executive function impairment and neuroanatomical correlates. | Research in developmental disabilities | 2017 | Yes |
| The role of near-infrared spectroscopy monitoring in preterm infants. | Journal of perinatology : official journal of the California Perinatal Association | 2017 | Yes |
| Motor and cognitive outcome after specific early lesions of the brain - a systematic review. | Developmental medicine and child neurology | 2016 | Yes |
Showing 5 of 83 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.