Condition (MeSH)
Malocclusion, Angle Class I
ClinicalTrials.gov lists 35 trials for Malocclusion, Angle Class I or a narrower condition beneath it. 3D-Aligners has the most among industry and government lead sponsors, with 1.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase (log scale)
35 of the 35 trials are tagged with Malocclusion, Angle Class I itself; the rest are tagged with a narrower condition beneath it.
When did Malocclusion, Angle Class I trials start? (12)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 4
- Not applicable
- Observational
Top of scale: 6
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 7 |
| 2025 | 4 |
| 2024 | 6 |
| 2023 | 1 |
| 2022 | 3 |
| 2021 | 2 |
| 2020 | 4 |
| 2019 | 2 |
| 2018 | 2 |
| 2017 | 2 |
Showing 10 of 12 earlier years.
No forecast is made for this condition: it averages 4.0 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 27 months from start to primary completion across 6 trials still running at the 2026-10-09 snapshot; registered median of 21 months across 19 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Malocclusion, Angle Class I trials in? (3)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 4 | 1 |
| Not applicable | 30 |
| Observational | 4 |
How many Malocclusion, Angle Class I trials are recruiting? (6)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 3 |
| Recruiting | 5 |
| Enrolling by invitation | 2 |
| Active, not recruiting | 2 |
| Completed | 18 |
Showing 5 of 6 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Malocclusion, Angle Class I trials? (1)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| 3D-Aligners | 1 |
Which drugs are being tested for Malocclusion, Angle Class I? (2)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Colloidal Silver | 1 |
| Calcitriol | 1 |
Interventions as named in the registry (3)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Low Level Laser Therapy | 2 |
| Mucograft | 1 |
| Chitosan | 1 |
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which publications cover Malocclusion, Angle Class I? (66)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Treatment effectiveness of young adults using clear aligners versus buccal fixed appliances in class I malocclusion with first premolar extraction using the ABO-Objective Grading System: A randomized controlled clinical trial. | International orthodontics | 2023 | Yes |
| Are clear aligners as effective as conventional fixed appliances? | Evidence-based dentistry | 2020 | Yes |
| Comparison of the accuracy of virtual and direct bonding of orthodontic accessories. | Dental press journal of orthodontics | 2019 | Yes |
| Comparison of piezocision and discision methods in orthodontic treatment. | Progress in orthodontics | 2018 | Yes |
| Accuracy of clear aligners: A retrospective study of patients who needed refinement. | American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics | 2018 | Yes |
Showing 5 of 66 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: serious adverse events in this condition's trials, prevalence, rare-disease identity, and sub-conditions in mesh.