Condition (MeSH)
Microcephaly
ClinicalTrials.gov lists 24 trials for Microcephaly or a narrower condition beneath it. Institut National de la Santé Et de la Recherche Médicale, France has the most among industry and government lead sponsors, with 2.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase
22 of the 24 trials are tagged with Microcephaly itself; the rest are tagged with a narrower condition beneath it.
When did Microcephaly trials start? (13)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1/2
- Not applicable
- Observational
Top of scale: 6
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2023 | 2 |
| 2022 | 1 |
| 2021 | 1 |
| 2019 | 2 |
| 2018 | 1 |
| 2017 | 2 |
| 2016 | 6 |
| 2015 | 1 |
| 2013 | 2 |
| 2010 | 2 |
Showing 10 of 13 earlier years.
No forecast is made for this condition: it averages 0.6 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 1 trial still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Microcephaly trials in? (3)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1/2 | 1 |
| Not applicable | 4 |
| Observational | 19 |
How many Microcephaly trials are recruiting? (5)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Recruiting | 5 |
| Completed | 16 |
| Terminated | 1 |
| Withdrawn | 1 |
| Unknown status | 1 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Microcephaly trials? (7)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Institut National de la Santé Et de la Recherche Médicale, France | 2 |
| Elpida Therapeutics SPC | 1 |
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 1 |
| Institut Pasteur | 1 |
| Laboratório Sabin | 1 |
Showing 5 of 7 sponsors.
Which drugs are being tested for Microcephaly? (4)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Betaine | 1 |
| Metafolin | 1 |
| Creatine | 1 |
| Cyanocobalamin | 1 |
Interventions as named in the registry (1)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| MELPIDA | 1 |
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Microcephaly trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Seizure | 18 | 1 |
| Insomnia | 14 | 1 |
| Infection | 7 | 1 |
| Anorexia | 2 | 1 |
| Behavior disturbance | 2 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Microcephaly? (68)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Zika in Infants and Pregnancy (ZIP) study: results from a prospective international cohort study of prenatal Zika virus infection and adverse fetal and infant outcomes. | BMC pregnancy and childbirth | 2025 | Yes |
| Preschool neurodevelopment in Zika virus-exposed children without congenital Zika syndrome. | Pediatric research | 2023 | Yes |
| H4C5 missense variant leads to a neurodevelopmental phenotype overlapping with Angelman syndrome. | American journal of medical genetics. Part A | 2023 | Yes |
| Dominant-negative variant in SLC1A4 causes an autosomal dominant epilepsy syndrome. | Annals of clinical and translational neurology | 2023 | Yes |
| CTNNB1-related neurodevelopmental disorder in a Chinese population: A case series. | American journal of medical genetics. Part A | 2022 | Yes |
Showing 5 of 68 publications.
Sub-conditions in MeSH (1)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.