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Condition (MeSH)

Myositis Ossificans

ClinicalTrials.gov lists 23 trials for Myositis Ossificans or a narrower condition beneath it. Clementia Pharmaceuticals Inc. has the most among industry and government lead sponsors, with 7.

MeSH D009221 Musculoskeletal Diseases C05
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Phase 1 Phase 1 3 Phase 2 Phase 2 7 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 4 Observational Observational 7 Expanded access Expanded access 1 Phase 1 Phase 1 3 Phase 2 Phase 2 7 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 4 Observational Observational 7 Expanded access Expanded access 1

Trials per phase

23 of the 23 trials are tagged with Myositis Ossificans itself; the rest are tagged with a narrower condition beneath it.

Get the Myositis Ossificans report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Myositis Ossificans trials start? (12)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Observational

Top of scale: 4

2013: 1 trials (Observational 1) 2014: 3 trials (Observational 1, Phase 2 2) 2015: 2 trials (Observational 1, Phase 2 1) 2017: 1 trials (Phase 3 1) 2018: 1 trials (Phase 2 1) 2019: 1 trials (Phase 1 1) 2020: 1 trials (Phase 2 1) 2021: 4 trials (Observational 1, Phase 2 1, Phase 1 2) 2022: 3 trials (Phase 3 2, Phase 2 1) 2023: 1 trials (Observational 1) 2024: 2 trials (Observational 1, Phase 2/3 1) 2025: 1 trials (Observational 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2025 1
2024 2
2023 1
2022 3
2021 4
2020 1
2019 1
2018 1
2017 1
2015 2

No forecast is made for this condition: it averages 1.8 trial starts a year over the five years to September, under the 5 a year the method needs.

Recruitment duration, a model prediction: 1 trial still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Myositis Ossificans trials in? (6)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 3
Phase 2 7
Phase 2/3 1
Phase 3 4
Observational 7
Expanded access 1

How many Myositis Ossificans trials are recruiting? (6)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 1
Recruiting 4
Active, not recruiting 3
Completed 12
Terminated 2

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Myositis Ossificans trials? (7)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Clementia Pharmaceuticals Inc. 7
Regeneron Pharmaceuticals 5
Ipsen 3
Incyte Corporation 2
Ashibio Inc 1

Which drugs are being tested for Myositis Ossificans? (6)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Palovarotene 5
Garetosmab 3
Andecaliximab 1
AZD0530 Difumarate 1
IPN60130 1

Interventions as named in the registry (7)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
INCB000928 2
Palovarotene dose level 1 1
D. Midazolam 1
Palovarotene dose level 4 1
Palovarotene dose level 3 1

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Myositis Ossificans trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Epiphyses Premature Fusion 21 1
Corona virus infection 18 2
Pneumonia 12 4
Condition aggravated 8 3
Exposure to communicable disease 7 2

Which publications cover Myositis Ossificans? (31)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Thoracic Deformity in Fibrodysplasia Ossificans Progressiva. JBJS reviews 2025 Yes
Matrix metalloproteinase-9 deficiency confers resilience in fibrodysplasia ossificans progressiva in a man and mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2024 Yes
Actionable disease insights from bedside-to-bench investigation in fibrodysplasia ossificans progressiva. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2024 Yes
Long-term use of interleukin-1 inhibitors reduce flare activity in patients with fibrodysplasia ossificans progressiva. Rheumatology (Oxford, England) 2024 Yes
Characterization of flare-ups and impact of garetosmab in adults with fibrodysplasia ossificans progressiva: a post hoc analysis of the randomized, double-blind, placebo-controlled LUMINA-1 trial. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2024 Yes

Prevalence (14)

Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.

Prevalence
Orphanet disease Type Class Geography Jurisdiction Mapping relation
Fibrodysplasia ossificans progressiva Point prevalence <1 / 1 000 000 United Kingdom GB Exact
Fibrodysplasia ossificans progressiva Point prevalence <1 / 1 000 000 United Kingdom GB Exact
Fibrodysplasia ossificans progressiva Point prevalence <1 / 1 000 000 United States US Exact
Fibrodysplasia ossificans progressiva Point prevalence <1 / 1 000 000 United States US Exact
Fibrodysplasia ossificans progressiva Point prevalence <1 / 1 000 000 Europe Not stated Exact

Rare-disease identity (2)

Shown in this order: exact, broader, narrower, other.

Rare-disease identity
Orphanet disease ORPHA code Relation Source
Fibrodysplasia ossificans progressiva 337 Exact Orphanet Rare Disease Ontology (ORDO)
Fibrodysplasia ossificans progressiva 337 Exact Orphadata Science knowledge files, Product 1

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: sub-conditions in mesh.

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