Condition (MeSH)
Paranasal Sinus Diseases
ClinicalTrials.gov lists 323 trials for Paranasal Sinus Diseases or a narrower condition beneath it. GlaxoSmithKline has the most among industry and government lead sponsors, with 7.
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Trials per phase (log scale)
24 of the 323 trials are tagged with Paranasal Sinus Diseases itself; the rest are tagged with a narrower condition beneath it.
When did Paranasal Sinus Diseases trials start? (28)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 20
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 12 |
| 2025 | 11 |
| 2024 | 18 |
| 2023 | 16 |
| 2022 | 18 |
| 2021 | 15 |
| 2020 | 12 |
| 2019 | 9 |
| 2018 | 16 |
| 2017 | 15 |
Showing 10 of 28 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 10 trials starting in 2026 and about 13 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored. The 2026 forecast is below the 12 already registered with a 2026 start date: at the cutoff, 5 trials were already registered to start in October to December, more than the method's monthly average allows for, and the method does not use those planned starts.
Prediction, not a registry value: median of 32 months from start to primary completion across 18 trials still running at the 2026-10-09 snapshot; registered median of 18 months across 207 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Paranasal Sinus Diseases trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 14 |
| Phase 1/2 | 10 |
| Phase 2 | 29 |
| Phase 2/3 | 4 |
| Phase 3 | 34 |
| Phase 4 | 40 |
| Not applicable | 115 |
| Observational | 77 |
How many Paranasal Sinus Diseases trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 10 |
| Recruiting | 22 |
| Enrolling by invitation | 2 |
| Active, not recruiting | 10 |
| Completed | 181 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Paranasal Sinus Diseases trials? (7)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| GlaxoSmithKline | 7 |
| Entellus Medical, Inc. | 6 |
| Integra LifeSciences Corporation | 6 |
| Sanofi | 5 |
| Bayer | 4 |
Showing 5 of 7 sponsors.
Which drugs are being tested for Paranasal Sinus Diseases? (4)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Amoxicillin | 4 |
| Telithromycin | 4 |
| Pseudoephedrine | 3 |
| Prednisone | 3 |
Interventions as named in the registry (11)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Amoxicillin and clavulanate | 13 |
| Budesonide EC | 7 |
| Cisplatin 1 | 6 |
| 1% Azithromycin | 6 |
| Levofloxacin 500 | 5 |
Showing 5 of 11 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Paranasal Sinus Diseases trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Pain | 26 | 4 |
| Fever | 25 | 3 |
| Dehydration | 21 | 3 |
| Mucositis oral | 17 | 1 |
| Infection NOS | 11 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Paranasal Sinus Diseases? (86)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| The Effect of Sphenopalatine Block on the Postoperative Pain of Endoscopic Sinus Surgery: A Meta-analysis. | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery | 2019 | Yes |
| Bilateral Silent Sinus (Imploding Antrum) Syndrome. | Ophthalmic plastic and reconstructive surgery | 2019 | Yes |
| Role of diffusion-weighted imaging in the discrimination of purulent intrasinusal content: A retrospective study. | Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery | 2019 | Yes |
| Revision rates and time to revision following endoscopic sinus surgery: A large database analysis. | The Laryngoscope | 2018 | Yes |
| Single-Blinded Prospective Implementation of a Preoperative Imaging Checklist for Endoscopic Sinus Surgery. | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery | 2018 | Yes |
Showing 5 of 86 publications.
Sub-conditions in MeSH (2)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.