Skip to content
Pharma Observatory a Scientist.com platform

Condition (MeSH)

Periapical Periodontitis

ClinicalTrials.gov lists 245 trials for Periapical Periodontitis or a narrower condition beneath it.

MeSH D010485 Stomatognathic Diseases C07
Email me this page as a PDF

Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Phase 1 Phase 1 11 Phase 1/2 Phase 1/2 1 Phase 2 Phase 2 7 Phase 2/3 Phase 2/3 8 Phase 3 Phase 3 2 Phase 4 Phase 4 11 Not applicable Not applicable 172 Observational Observational 33 Phase 1 Phase 1 11 Phase 1/2 Phase 1/2 1 Phase 2 Phase 2 7 Phase 2/3 Phase 2/3 8 Phase 3 Phase 3 2 Phase 4 Phase 4 11 Not applicable Not applicable 172 Observational Observational 33

Trials per phase (log scale)

228 of the 245 trials are tagged with Periapical Periodontitis itself; the rest are tagged with a narrower condition beneath it.

Get the Periapical Periodontitis report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Periapical Periodontitis trials start? (23)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 2 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 35

2002: 1 trials (Not applicable 1) 2004: 1 trials (Not applicable 1) 2005: 2 trials (Observational 1, Phase 1 1) 2006: 1 trials (Not applicable 1) 2008: 1 trials (Observational 1) 2009: 1 trials (Observational 1) 2010: 1 trials (Not applicable 1) 2011: 1 trials (Phase 4 1) 2012: 3 trials (Not applicable 1, Phase 2 1, Phase 1 1) 2013: 4 trials (Not applicable 3, Phase 4 1) 2014: 4 trials (Not applicable 3, Phase 4 1) 2015: 5 trials (Not applicable 4, Phase 4 1) 2016: 15 trials (Observational 4, Not applicable 8, Phase 4 1, Phase 2/3 1, Phase 1 1) 2017: 10 trials (Observational 1, Not applicable 9) 2018: 6 trials (Not applicable 4, Phase 2/3 1, Phase 2 1) 2019: 14 trials (Observational 1, Not applicable 10, Phase 2/3 1, Phase 2 1, Phase 1 1) 2020: 16 trials (Observational 1, Not applicable 12, Phase 4 1, Phase 2 2) 2021: 23 trials (Observational 6, Not applicable 16, Phase 2/3 1) 2022: 18 trials (Observational 4, Not applicable 11, Phase 2 1, Phase 1 2) 2023: 30 trials (Observational 2, Not applicable 25, Phase 4 1, Phase 3 1, Phase 2/3 1) 2024: 28 trials (Observational 3, Not applicable 25) 2025: 35 trials (Observational 3, Not applicable 24, Phase 4 2, Phase 2/3 2, Phase 2 1, Phase 1/2 1, Phase 1 2)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 23
2025 35
2024 28
2023 30
2022 18
2021 23
2020 16
2019 14
2018 6
2017 10

Forecast of the full-year count, planned starts included, not rows of this table: about 30 trials starting in 2026 and about 30 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 24 months from start to primary completion across 17 trials still running at the 2026-10-09 snapshot; registered median of 12 months across 152 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Periapical Periodontitis trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 11
Phase 1/2 1
Phase 2 7
Phase 2/3 8
Phase 3 2
Phase 4 11
Not applicable 172
Observational 33

How many Periapical Periodontitis trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 25
Recruiting 23
Enrolling by invitation 3
Active, not recruiting 12
Completed 139

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which drugs are being tested for Periapical Periodontitis? (2)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Sodium Hypochlorite 4
Articaine 3

Interventions as named in the registry (13)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Calcium Hydroxide 8
2% chlorhexidine 3
Diclofenac 3% 3
Control (placebo) group 3
root canal treatment and intracanal medicament 3

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which publications cover Periapical Periodontitis? (229)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Sub-conditions in MeSH (2)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: lead sponsors, serious adverse events in this condition's trials, prevalence, and rare-disease identity.

Browse all condition evidence pages