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Condition (MeSH)

Polycystic Ovary Syndrome

ClinicalTrials.gov lists 939 trials for Polycystic Ovary Syndrome or a narrower condition beneath it.

MeSH D011085 Neoplasms Neoplasm C04 C12 C19 Listed by Orphanet as a rare disease
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Phase 1 Phase 1 56 Phase 1/2 Phase 1/2 15 Phase 2 Phase 2 43 Phase 2/3 Phase 2/3 19 Phase 3 Phase 3 61 Phase 4 Phase 4 120 Not applicable Not applicable 397 Observational Observational 228 Phase 1 Phase 1 56 Phase 1/2 Phase 1/2 15 Phase 2 Phase 2 43 Phase 2/3 Phase 2/3 19 Phase 3 Phase 3 61 Phase 4 Phase 4 120 Not applicable Not applicable 397 Observational Observational 228

Trials per phase (log scale)

939 of the 939 trials are tagged with Polycystic Ovary Syndrome itself; the rest are tagged with a narrower condition beneath it.

Get the Polycystic Ovary Syndrome report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Polycystic Ovary Syndrome trials start? (28)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 71

1997: 1 trials (Phase 3 1) 2000: 6 trials (Observational 2, Not applicable 3, Phase 2 1) 2001: 4 trials (Observational 1, Not applicable 1, Phase 4 1, Phase 2/3 1) 2002: 6 trials (Observational 1, Not applicable 1, Phase 4 1, Phase 3 3) 2003: 12 trials (Observational 5, Phase 4 6, Phase 3 1) 2004: 12 trials (Observational 4, Not applicable 2, Phase 4 4, Phase 2 2) 2005: 14 trials (Observational 3, Not applicable 6, Phase 4 3, Phase 3 1, Phase 1 1) 2006: 24 trials (Observational 4, Not applicable 13, Phase 4 3, Phase 3 2, Phase 2 1, Phase 1 1) 2007: 20 trials (Observational 3, Not applicable 8, Phase 4 3, Phase 3 4, Phase 2/3 1, Phase 2 1) 2008: 29 trials (Observational 3, Not applicable 12, Phase 4 6, Phase 3 4, Phase 2 2, Phase 1 2) 2009: 32 trials (Observational 9, Not applicable 11, Phase 4 3, Phase 3 2, Phase 1/2 2, Phase 1 5) 2010: 24 trials (Observational 5, Not applicable 13, Phase 4 4, Phase 3 1, Phase 1 1) 2011: 31 trials (Observational 9, Not applicable 11, Phase 4 4, Phase 3 3, Phase 2 1, Phase 1 3) 2012: 52 trials (Observational 17, Not applicable 16, Phase 4 10, Phase 3 4, Phase 2/3 1, Phase 1 4) 2013: 38 trials (Observational 13, Not applicable 10, Phase 4 9, Phase 3 2, Phase 2 2, Phase 1 2) 2014: 32 trials (Observational 5, Not applicable 12, Phase 4 7, Phase 3 4, Phase 2/3 1, Phase 2 1, Phase 1 2) 2015: 42 trials (Observational 6, Not applicable 23, Phase 4 4, Phase 3 2, Phase 2 5, Phase 1 2) 2016: 46 trials (Observational 13, Not applicable 13, Phase 4 8, Phase 3 2, Phase 2/3 4, Phase 2 4, Phase 1 2) 2017: 38 trials (Observational 9, Not applicable 12, Phase 4 6, Phase 3 1, Phase 2/3 1, Phase 2 1, Phase 1/2 1, Phase 1 7) 2018: 40 trials (Observational 10, Not applicable 16, Phase 4 2, Phase 3 4, Phase 2 3, Phase 1/2 1, Phase 1 4) 2019: 38 trials (Observational 8, Not applicable 14, Phase 4 6, Phase 3 1, Phase 2/3 2, Phase 2 2, Phase 1/2 3, Phase 1 2) 2020: 41 trials (Observational 12, Not applicable 15, Phase 4 10, Phase 3 2, Phase 2 1, Phase 1/2 1) 2021: 50 trials (Observational 14, Not applicable 26, Phase 4 3, Phase 3 1, Phase 2 1, Phase 1/2 2, Phase 1 3) 2022: 52 trials (Observational 11, Not applicable 29, Phase 4 2, Phase 2/3 1, Phase 2 4, Phase 1/2 1, Phase 1 4) 2023: 64 trials (Observational 18, Not applicable 25, Phase 4 6, Phase 3 7, Phase 2/3 2, Phase 2 2, Phase 1/2 2, Phase 1 2) 2024: 60 trials (Observational 15, Not applicable 29, Phase 4 1, Phase 3 4, Phase 2/3 3, Phase 2 2, Phase 1/2 2, Phase 1 4) 2025: 71 trials (Observational 18, Not applicable 36, Phase 4 5, Phase 3 3, Phase 2/3 2, Phase 2 4, Phase 1 3)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 50
2025 71
2024 60
2023 64
2022 52
2021 50
2020 41
2019 38
2018 40
2017 38

Forecast of the full-year count, planned starts included, not rows of this table: about 65 trials starting in 2026 and about 65 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 62 trials still running at the 2026-10-09 snapshot; registered median of 18 months across 546 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Polycystic Ovary Syndrome trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 56
Phase 1/2 15
Phase 2 43
Phase 2/3 19
Phase 3 61
Phase 4 120
Not applicable 397
Observational 228

How many Polycystic Ovary Syndrome trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 41
Recruiting 83
Enrolling by invitation 4
Active, not recruiting 18
Completed 513

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which drugs are being tested for Polycystic Ovary Syndrome? (4)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Myo-inositol 13
Calcium/Vitamin D 8
Folic (or folinic) acid 7
Calcium-vitamin D3 6

Interventions as named in the registry (11)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
1% Metformin 141
clomiphen citrate 38
Letrozol (Femara, Novartis) 35
Progesterone 8% 10
r-hCG 10

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Polycystic Ovary Syndrome trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Ectopic Pregnancy 9 2
Hospitalization 8 1
Congenital Anomaly 5 1
Ovarian Hyperstimulation syndrome 5 1
Pregnancy 4 1

Which publications cover Polycystic Ovary Syndrome? (1,313)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: lead sponsors, prevalence, rare-disease identity, and sub-conditions in mesh.

Browse all condition evidence pages