Condition (MeSH)
Hyperacusis
ClinicalTrials.gov lists 32 trials for Hyperacusis or a narrower condition beneath it. Pfizer has the most among industry and government lead sponsors, with 8.
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Trials per phase
32 of the 32 trials are tagged with Hyperacusis itself; the rest are tagged with a narrower condition beneath it.
When did Hyperacusis trials start? (17)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 3
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 1 |
| 2025 | 2 |
| 2024 | 2 |
| 2023 | 1 |
| 2022 | 3 |
| 2021 | 3 |
| 2020 | 3 |
| 2019 | 3 |
| 2018 | 1 |
| 2017 | 3 |
Showing 10 of 17 earlier years.
No forecast is made for this condition: it averages 1.8 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 3 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Hyperacusis trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 1 |
| Phase 1/2 | 1 |
| Phase 2/3 | 3 |
| Phase 3 | 5 |
| Phase 4 | 2 |
| Not applicable | 13 |
| Observational | 6 |
| Expanded access | 1 |
How many Hyperacusis trials are recruiting? (7)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 1 |
| Recruiting | 6 |
| Completed | 12 |
| Terminated | 3 |
| Withdrawn | 3 |
Showing 5 of 7 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Hyperacusis trials? (6)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Pfizer | 8 |
| Achelios Therapeutics | 1 |
| Linkoeping University | 1 |
| Mayfair Developments | 1 |
| Neuromonics, Inc. | 1 |
Showing 5 of 6 sponsors.
Which drugs are being tested for Hyperacusis? (2)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Zavegepant | 3 |
| Rimegepant | 1 |
Interventions as named in the registry (4)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Rimegepant/BHV3000 | 4 |
| Transcranial Magnetic Stimulation | 1 |
| PRO-513 | 1 |
| ELS-M11 | 1 |
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Hyperacusis trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| COVID-19 | 2 | 1 |
| Cholecystitis | 2 | 1 |
| Hypertensive heart disease | 2 | 1 |
| Iron deficiency anaemia | 2 | 1 |
| Abortion spontaneous | 1 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Hyperacusis? (26)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Short- and long-term changes in auditory sensitivity and tinnitus distress between acute and chronic tinnitus: Longitudinal observation in a community-based sample. | Hearing research | 2025 | Yes |
| Pilot study on the role of somatic modulation in hyperacusis. | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery | 2023 | Yes |
| Fibromyalgia Patients Are Not Only Hypersensitive to Painful Stimuli But Also to Acoustic Stimuli. | The journal of pain | 2021 | Yes |
| A psychoacoustic test for misophonia assessment. | Scientific reports | 2021 | Yes |
| A randomized study of IV prochlorperazine plus diphenhydramine versus IV hydromorphone for migraine-associated symptoms: A post hoc analysis. | Headache | 2021 | Yes |
Showing 5 of 26 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.