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Condition (MeSH)

Recurrence

ClinicalTrials.gov lists 3,542 trials for Recurrence or a narrower condition beneath it. Celgene has the most among industry and government lead sponsors, with 53.

MeSH D012008 Pathological Conditions, Signs and Symptoms C23
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Phase 1 Phase 1 770 Phase 1/2 Phase 1/2 399 Phase 2 Phase 2 892 Phase 2/3 Phase 2/3 53 Phase 3 Phase 3 259 Phase 4 Phase 4 125 Not applicable Not applicable 493 Observational Observational 516 Phase 1 Phase 1 770 Phase 1/2 Phase 1/2 399 Phase 2 Phase 2 892 Phase 2/3 Phase 2/3 53 Phase 3 Phase 3 259 Phase 4 Phase 4 125 Not applicable Not applicable 493 Observational Observational 516

Trials per phase

1 more section with rows

3,501 of the 3,542 trials are tagged with Recurrence itself; the rest are tagged with a narrower condition beneath it.

Get the Recurrence report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Recurrence trials start? (37)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 6 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational
  • Other (Expanded access)

Top of scale: 218

1990: 1 trials (Phase 2 1) 1991: 2 trials (Phase 2 2) 1992: 3 trials (Observational 1, Phase 2 1, Phase 1 1) 1993: 1 trials (Phase 2 1) 1994: 3 trials (Observational 1, Phase 2 1, Phase 1 1) 1995: 7 trials (Observational 2, Not applicable 2, Phase 2 1, Phase 1/2 1, Phase 1 1) 1996: 7 trials (Observational 2, Phase 2 4, Phase 1 1) 1997: 12 trials (Observational 2, Not applicable 2, Phase 3 2, Phase 2 5, Phase 1 1) 1998: 15 trials (Observational 1, Not applicable 2, Phase 4 1, Phase 3 1, Phase 2 9, Phase 1 1) 1999: 22 trials (Observational 2, Not applicable 2, Phase 3 8, Phase 2 7, Phase 1 3) 2000: 34 trials (Observational 5, Not applicable 2, Phase 4 1, Phase 3 4, Phase 2 8, Phase 1/2 7, Phase 1 7) 2001: 28 trials (Observational 1, Not applicable 6, Phase 4 1, Phase 3 2, Phase 2/3 1, Phase 2 11, Phase 1/2 1, Phase 1 5) 2002: 27 trials (Observational 5, Not applicable 3, Phase 4 5, Phase 3 2, Phase 2 10, Phase 1 2) 2003: 38 trials (Observational 2, Not applicable 10, Phase 4 1, Phase 3 4, Phase 2/3 2, Phase 2 11, Phase 1/2 5, Phase 1 3) 2004: 63 trials (Observational 5, Not applicable 7, Phase 4 6, Phase 3 8, Phase 2/3 1, Phase 2 22, Phase 1/2 5, Phase 1 9) 2005: 81 trials (Observational 10, Not applicable 5, Phase 4 5, Phase 3 10, Phase 2 29, Phase 1/2 8, Phase 1 14) 2006: 75 trials (Observational 10, Not applicable 7, Phase 4 3, Phase 3 4, Phase 2/3 1, Phase 2 30, Phase 1/2 7, Phase 1 13) 2007: 95 trials (Other 1, Observational 12, Not applicable 9, Phase 4 8, Phase 3 10, Phase 2/3 1, Phase 2 36, Phase 1/2 5, Phase 1 13) 2008: 89 trials (Observational 8, Not applicable 15, Phase 4 6, Phase 3 6, Phase 2 24, Phase 1/2 12, Phase 1 18) 2009: 111 trials (Observational 13, Not applicable 13, Phase 4 6, Phase 3 6, Phase 2/3 3, Phase 2 40, Phase 1/2 5, Phase 1 25) 2010: 112 trials (Observational 16, Not applicable 18, Phase 4 2, Phase 3 12, Phase 2/3 4, Phase 2 32, Phase 1/2 13, Phase 1 15) 2011: 106 trials (Observational 7, Not applicable 8, Phase 4 2, Phase 3 16, Phase 2/3 1, Phase 2 30, Phase 1/2 16, Phase 1 26) 2012: 113 trials (Observational 12, Not applicable 12, Phase 4 4, Phase 3 9, Phase 2/3 3, Phase 2 41, Phase 1/2 12, Phase 1 20) 2013: 103 trials (Observational 11, Not applicable 19, Phase 4 5, Phase 3 7, Phase 2/3 1, Phase 2 31, Phase 1/2 12, Phase 1 17) 2014: 146 trials (Observational 21, Not applicable 18, Phase 4 6, Phase 3 12, Phase 2/3 2, Phase 2 35, Phase 1/2 16, Phase 1 36) 2015: 154 trials (Observational 25, Not applicable 26, Phase 4 6, Phase 3 17, Phase 2/3 3, Phase 2 34, Phase 1/2 13, Phase 1 30) 2016: 153 trials (Observational 21, Not applicable 23, Phase 4 3, Phase 3 12, Phase 2/3 3, Phase 2 29, Phase 1/2 21, Phase 1 41) 2017: 160 trials (Observational 21, Not applicable 27, Phase 4 7, Phase 3 13, Phase 2/3 4, Phase 2 31, Phase 1/2 21, Phase 1 36) 2018: 164 trials (Observational 33, Not applicable 15, Phase 4 6, Phase 3 12, Phase 2/3 2, Phase 2 42, Phase 1/2 14, Phase 1 40) 2019: 179 trials (Observational 31, Not applicable 29, Phase 4 3, Phase 3 9, Phase 2/3 2, Phase 2 34, Phase 1/2 18, Phase 1 53) 2020: 164 trials (Observational 46, Not applicable 23, Phase 4 6, Phase 3 3, Phase 2/3 3, Phase 2 33, Phase 1/2 22, Phase 1 28) 2021: 189 trials (Observational 29, Not applicable 29, Phase 4 3, Phase 3 13, Phase 2/3 2, Phase 2 43, Phase 1/2 23, Phase 1 47) 2022: 187 trials (Observational 41, Not applicable 35, Phase 4 2, Phase 3 6, Phase 2/3 1, Phase 2 35, Phase 1/2 22, Phase 1 45) 2023: 207 trials (Observational 32, Not applicable 33, Phase 4 6, Phase 3 14, Phase 2/3 1, Phase 2 38, Phase 1/2 28, Phase 1 55) 2024: 202 trials (Observational 33, Not applicable 32, Phase 4 11, Phase 3 8, Phase 2/3 1, Phase 2 41, Phase 1/2 30, Phase 1 46) 2025: 218 trials (Observational 21, Not applicable 28, Phase 4 9, Phase 3 13, Phase 2/3 7, Phase 2 52, Phase 1/2 28, Phase 1 60)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 207
2025 218
2024 202
2023 207
2022 187
2021 189
2020 164
2019 179
2018 164
2017 160

Forecast of the full-year count, planned starts included, not rows of this table: about 230 trials starting in 2026 and about 230 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 13 percent and ran about 12 percent low against the count later registered; forecasts made before the year began were off by about 19 percent and ran about 17 percent low against the count later registered, and had about the same error as repeating last year's count. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 485 trials still running at the 2026-10-09 snapshot; registered median of 37 months across 1,884 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Recurrence trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 770
Phase 1/2 399
Phase 2 892
Phase 2/3 53
Phase 3 259
Phase 4 125
Not applicable 493
Observational 516
Expanded access 35

How many Recurrence trials are recruiting? (13)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 194
Recruiting 547
Enrolling by invitation 15
Active, not recruiting 195
Available 6

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Recurrence trials? (7)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Celgene 53
Novartis Pharmaceuticals 50
National Cancer Institute (NCI) 39
AbbVie 26
Amgen 24

Which drugs are being tested for Recurrence? (6)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Cytoxan 143
RITUXIMAB 80
PEMBROLIZUMAB 48
POMALIDOMIDE 47
(nab)-paclitaxel 39

Interventions as named in the registry (9)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Dexamethasone/Dexamethasone acetate 129
SQ Fludarabine 116
Cytarabine IT 63
X: Lenalidomide 61
Bortezomib SC 56

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Recurrence trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Pneumonia 1,790 212
Febrile neutropenia 1,109 142
Pyrexia 877 165
death 825 4
Sepsis 640 170

Which publications cover Recurrence? (10,655)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Sub-conditions in MeSH (2)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages