Condition (MeSH)
Reflex Sympathetic Dystrophy
ClinicalTrials.gov lists 43 trials for Reflex Sympathetic Dystrophy or a narrower condition beneath it. Grünenthal GmbH has the most among industry and government lead sponsors, with 3.
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Trials per phase
43 of the 43 trials are tagged with Reflex Sympathetic Dystrophy itself; the rest are tagged with a narrower condition beneath it.
When did Reflex Sympathetic Dystrophy trials start? (23)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 4
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 2 |
| 2025 | 2 |
| 2024 | 1 |
| 2023 | 2 |
| 2022 | 2 |
| 2021 | 3 |
| 2019 | 1 |
| 2018 | 4 |
| 2017 | 3 |
| 2015 | 3 |
Showing 10 of 23 earlier years.
No forecast is made for this condition: it averages 2.0 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 2 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Reflex Sympathetic Dystrophy trials in? (7)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1/2 | 2 |
| Phase 2 | 4 |
| Phase 2/3 | 4 |
| Phase 3 | 6 |
| Phase 4 | 2 |
| Not applicable | 20 |
| Observational | 5 |
How many Reflex Sympathetic Dystrophy trials are recruiting? (5)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Recruiting | 4 |
| Completed | 22 |
| Terminated | 6 |
| Withdrawn | 4 |
| Unknown status | 7 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Reflex Sympathetic Dystrophy trials? (7)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Grünenthal GmbH | 3 |
| Ambros Therapeutics, Inc. | 2 |
| Celgene Corporation | 2 |
| National Institute of Nursing Research (NINR) | 2 |
| Ankara Etlik City Hospital | 1 |
Showing 5 of 7 sponsors.
Which drugs are being tested for Reflex Sympathetic Dystrophy? (1)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Neridronic acid | 3 |
Interventions as named in the registry (14)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| X: Lenalidomide | 2 |
| Acupuncture | 1 |
| Suprascapular and median nerve blocks | 1 |
| Intravenous Immunoglobulins | 1 |
| Diclofenac 3% | 1 |
Showing 5 of 14 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Reflex Sympathetic Dystrophy trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Increase pain | 8 | 1 |
| Burning sensation | 7 | 1 |
| Light headache | 5 | 1 |
| Deep vein thrombosis | 3 | 1 |
| Abdominal pain upper | 2 | 2 |
Showing 5 of 10 adverse events.
Which publications cover Reflex Sympathetic Dystrophy? (146)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Effect of high-intensity laser therapy and mirror therapy on complex regional pain syndrome type I in the hand area: A randomized controlled trial. | Journal of hand therapy : official journal of the American Society of Hand Therapists | 2025 | Yes |
| Effects of mirror therapy in post-traumatic complex regional pain syndrome type-1: a randomized controlled study. | Journal of rehabilitation medicine | 2024 | Yes |
| The Effectiveness of Rehabilitation Interventions on Pain and Disability for Complex Regional Pain Syndrome: A Systematic Review and Meta-analysis. | The Clinical journal of pain | 2023 | Yes |
| Sympathetic Blocks as a Predictor for Response to Ketamine Infusion in Patients with Complex Regional Pain Syndrome: A Multicenter Study. | Pain medicine (Malden, Mass.) | 2023 | Yes |
| Complex Regional Pain Syndrome: Practical Diagnostic and Treatment Guidelines, 5th Edition. | Pain medicine (Malden, Mass.) | 2022 | Yes |
Showing 5 of 146 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.