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Condition (MeSH)

Complex Regional Pain Syndromes

ClinicalTrials.gov lists 226 trials for Complex Regional Pain Syndromes or a narrower condition beneath it.

MeSH D020918 Nervous System Diseases C10 Listed by Orphanet as a rare disease
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Phase 1 Phase 1 5 Phase 1/2 Phase 1/2 2 Phase 2 Phase 2 15 Phase 2/3 Phase 2/3 5 Phase 3 Phase 3 19 Phase 4 Phase 4 8 Not applicable Not applicable 122 Observational Observational 49 Phase 1 Phase 1 5 Phase 1/2 Phase 1/2 2 Phase 2 Phase 2 15 Phase 2/3 Phase 2/3 5 Phase 3 Phase 3 19 Phase 4 Phase 4 8 Not applicable Not applicable 122 Observational Observational 49

Trials per phase (log scale)

1 more section with rows

202 of the 226 trials are tagged with Complex Regional Pain Syndromes itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Complex Regional Pain Syndromes trials start? (28)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 19

1992: 1 trials (Observational 1) 2000: 1 trials (Phase 2 1) 2001: 1 trials (Phase 4 1) 2002: 1 trials (Observational 1) 2003: 3 trials (Not applicable 1, Phase 4 1, Phase 2 1) 2004: 1 trials (Phase 2 1) 2005: 5 trials (Observational 1, Not applicable 1, Phase 4 1, Phase 3 1, Phase 2 1) 2006: 5 trials (Not applicable 1, Phase 3 1, Phase 2/3 1, Phase 2 2) 2007: 9 trials (Observational 4, Not applicable 2, Phase 3 3) 2008: 8 trials (Observational 2, Not applicable 4, Phase 3 1, Phase 2 1) 2009: 7 trials (Not applicable 1, Phase 3 4, Phase 2/3 1, Phase 1/2 1) 2010: 3 trials (Observational 1, Not applicable 1, Phase 3 1) 2011: 5 trials (Observational 2, Not applicable 2, Phase 2 1) 2012: 6 trials (Not applicable 6) 2013: 8 trials (Not applicable 6, Phase 2/3 1, Phase 2 1) 2014: 7 trials (Observational 1, Not applicable 4, Phase 4 1, Phase 2 1) 2015: 8 trials (Not applicable 4, Phase 3 1, Phase 2/3 1, Phase 2 1, Phase 1 1) 2016: 13 trials (Observational 2, Not applicable 7, Phase 3 2, Phase 1 2) 2017: 12 trials (Observational 3, Not applicable 8, Phase 4 1) 2018: 13 trials (Observational 3, Not applicable 6, Phase 3 2, Phase 1/2 1, Phase 1 1) 2019: 9 trials (Observational 3, Not applicable 4, Phase 3 1, Phase 2 1) 2020: 2 trials (Observational 1, Not applicable 1) 2021: 16 trials (Observational 3, Not applicable 12, Phase 2/3 1) 2022: 13 trials (Observational 3, Not applicable 10) 2023: 19 trials (Observational 5, Not applicable 12, Phase 4 2) 2024: 16 trials (Observational 3, Not applicable 10, Phase 4 1, Phase 2 1, Phase 1 1) 2025: 15 trials (Observational 5, Not applicable 10)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 16
2025 15
2024 16
2023 19
2022 13
2021 16
2020 2
2019 9
2018 13
2017 12

Showing 10 of 28 earlier years.

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Forecast of the full-year count, planned starts included, not rows of this table: about 15 trials starting in 2026 and about 15 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored. The 2026 forecast is below the 16 already registered with a 2026 start date: at the cutoff, 5 trials were already registered to start in October to December, more than the method's monthly average allows for, and the method does not use those planned starts.

Prediction, not a registry value: median of 36 months from start to primary completion across 22 trials still running at the 2026-10-09 snapshot; registered median of 19 months across 127 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Complex Regional Pain Syndromes trials in? (9)

Shown in this order: phase order.

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Trials by phase
Phase Trials
Phase 1 5
Phase 1/2 2
Phase 2 15
Phase 2/3 5
Phase 3 19
Phase 4 8
Not applicable 122
Observational 49
Expanded access 1

How many Complex Regional Pain Syndromes trials are recruiting? (10)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 9
Recruiting 30
Enrolling by invitation 5
Active, not recruiting 4
Completed 108

Showing 5 of 10 statuses.

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Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Complex Regional Pain Syndromes trials? (5)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Amgen 4
Grünenthal GmbH 4
Ambros Therapeutics, Inc. 3
National Institute of Nursing Research (NINR) 3
Ankara Etlik City Hospital 2

Which drugs are being tested for Complex Regional Pain Syndromes? (3)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
PMI-150 (intranasal ketamine) 5
Neridronic acid 4
Vitamin C 2

Interventions as named in the registry (12)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Transcranial Magnetic Stimulation 4
L:Lidocaine 4
Ibuprofen 2% 3
HZT-501 3
Conventional Therapy 2

Showing 5 of 12 interventions.

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These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Complex Regional Pain Syndromes trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Pneumonia 10 4
Increase pain 8 1
Burning sensation 7 1
Deep vein thrombosis 5 2
Fall 5 4

Showing 5 of 10 adverse events.

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Which publications cover Complex Regional Pain Syndromes? (226)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Complex regional pain syndrome evolution is determined by both biological and psychosocial factors: a 1-year prospective observational study. Pain 2026 Yes
Cognitive Function in Patients With Complex Regional Pain Syndrome (CRPS). European journal of pain (London, England) 2025 Yes
Neural Correlates of Pain-Autonomic Coupling in Patients With Complex Regional Pain Syndrome Treated by Repetitive Transcranial Magnetic Stimulation of the Motor Cortex. Neuromodulation : journal of the International Neuromodulation Society 2024 Yes
Targeted Nerve Root Stimulation Alleviates Intractable Chronic Limb Pain Associated with Complex Regional Pain Syndrome - A Prospective Multi-Center Feasibility Study. Pain physician 2024 Yes
The Effectiveness of Rehabilitation Interventions on Pain and Disability for Complex Regional Pain Syndrome: A Systematic Review and Meta-analysis. The Clinical journal of pain 2023 Yes

Showing 5 of 226 publications.

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Prevalence (6)

Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.

Prevalence
Orphanet disease Type Class Geography Jurisdiction Mapping relation
Complex regional pain syndrome Point prevalence Unknown Worldwide Not stated Exact
Complex regional pain syndrome Point prevalence Unknown Worldwide Not stated Exact
Complex regional pain syndrome Annual incidence 1-5 / 10 000 Netherlands Not stated Unspecified
Complex regional pain syndrome Annual incidence 1-5 / 10 000 Netherlands Not stated Exact
Complex regional pain syndrome Point prevalence Unknown Worldwide Not stated Unspecified

Showing 5 of 6 prevalence observations.

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Rare-disease identity (2)

Shown in this order: exact, broader, narrower, other.

Rare-disease identity
Orphanet disease ORPHA code Relation Source
Complex regional pain syndrome 83452 Exact Orphanet Rare Disease Ontology (ORDO)
Complex regional pain syndrome 83452 Exact Orphadata Science knowledge files, Product 1

Sub-conditions in MeSH (2)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

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