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Condition (MeSH)

Salivary Gland Diseases

ClinicalTrials.gov lists 956 trials for Salivary Gland Diseases or a narrower condition beneath it. National Cancer Institute (NCI) has the most among industry and government lead sponsors, with 43.

MeSH D012466 Stomatognathic Diseases C07
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Phase 1 Phase 1 114 Phase 1/2 Phase 1/2 48 Phase 2 Phase 2 182 Phase 2/3 Phase 2/3 14 Phase 3 Phase 3 85 Phase 4 Phase 4 49 Not applicable Not applicable 249 Observational Observational 214 Phase 1 Phase 1 114 Phase 1/2 Phase 1/2 48 Phase 2 Phase 2 182 Phase 2/3 Phase 2/3 14 Phase 3 Phase 3 85 Phase 4 Phase 4 49 Not applicable Not applicable 249 Observational Observational 214

Trials per phase

1 more section with rows

17 of the 956 trials are tagged with Salivary Gland Diseases itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Salivary Gland Diseases trials start? (33)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 2 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 62

1993: 1 trials (Observational 1) 1995: 3 trials (Observational 1, Phase 2 1, Phase 1 1) 1996: 2 trials (Observational 1, Phase 2 1) 1997: 8 trials (Phase 2 5, Phase 1/2 2, Phase 1 1) 1998: 6 trials (Observational 1, Phase 3 1, Phase 2 3, Phase 1 1) 1999: 13 trials (Observational 2, Phase 4 1, Phase 3 2, Phase 2 4, Phase 1 4) 2000: 18 trials (Observational 1, Not applicable 1, Phase 4 1, Phase 3 5, Phase 2 4, Phase 1 6) 2001: 14 trials (Observational 2, Phase 3 3, Phase 2 2, Phase 1/2 1, Phase 1 6) 2002: 15 trials (Observational 2, Phase 3 2, Phase 2 7, Phase 1/2 2, Phase 1 2) 2003: 18 trials (Observational 4, Not applicable 5, Phase 4 1, Phase 3 1, Phase 2/3 1, Phase 2 4, Phase 1 2) 2004: 25 trials (Observational 6, Not applicable 2, Phase 4 1, Phase 3 3, Phase 2 7, Phase 1 6) 2005: 22 trials (Observational 4, Phase 4 2, Phase 3 4, Phase 2 7, Phase 1/2 2, Phase 1 3) 2006: 27 trials (Observational 5, Not applicable 4, Phase 4 3, Phase 3 5, Phase 2 6, Phase 1/2 1, Phase 1 3) 2007: 39 trials (Observational 11, Not applicable 4, Phase 4 4, Phase 3 6, Phase 2 10, Phase 1/2 1, Phase 1 3) 2008: 25 trials (Observational 7, Not applicable 3, Phase 4 2, Phase 3 5, Phase 2/3 2, Phase 2 3, Phase 1 3) 2009: 21 trials (Observational 2, Not applicable 3, Phase 3 1, Phase 2/3 2, Phase 2 8, Phase 1/2 2, Phase 1 3) 2010: 26 trials (Observational 7, Not applicable 6, Phase 4 2, Phase 3 2, Phase 2/3 1, Phase 2 6, Phase 1/2 1, Phase 1 1) 2011: 26 trials (Observational 3, Not applicable 4, Phase 4 1, Phase 3 2, Phase 2/3 3, Phase 2 7, Phase 1/2 1, Phase 1 5) 2012: 30 trials (Observational 9, Not applicable 6, Phase 4 2, Phase 3 5, Phase 2 5, Phase 1/2 1, Phase 1 2) 2013: 28 trials (Observational 9, Not applicable 7, Phase 4 2, Phase 3 2, Phase 2 4, Phase 1/2 2, Phase 1 2) 2014: 36 trials (Observational 7, Not applicable 13, Phase 3 6, Phase 2 6, Phase 1/2 1, Phase 1 3) 2015: 31 trials (Observational 11, Not applicable 6, Phase 4 2, Phase 3 2, Phase 2 6, Phase 1/2 2, Phase 1 2) 2016: 38 trials (Observational 5, Not applicable 12, Phase 4 5, Phase 3 2, Phase 2 10, Phase 1/2 2, Phase 1 2) 2017: 33 trials (Observational 4, Not applicable 17, Phase 4 1, Phase 3 1, Phase 2 6, Phase 1/2 3, Phase 1 1) 2018: 35 trials (Observational 9, Not applicable 13, Phase 4 2, Phase 3 2, Phase 2 3, Phase 1/2 3, Phase 1 3) 2019: 41 trials (Observational 11, Not applicable 16, Phase 2 7, Phase 1/2 2, Phase 1 5) 2020: 52 trials (Observational 10, Not applicable 24, Phase 4 1, Phase 2/3 1, Phase 2 8, Phase 1/2 4, Phase 1 4) 2021: 62 trials (Observational 19, Not applicable 18, Phase 4 5, Phase 3 3, Phase 2/3 1, Phase 2 10, Phase 1/2 1, Phase 1 5) 2022: 43 trials (Observational 10, Not applicable 17, Phase 4 1, Phase 3 2, Phase 2 8, Phase 1/2 2, Phase 1 3) 2023: 49 trials (Observational 10, Not applicable 16, Phase 4 4, Phase 3 5, Phase 2/3 3, Phase 2 5, Phase 1/2 2, Phase 1 4) 2024: 61 trials (Observational 16, Not applicable 22, Phase 4 3, Phase 3 6, Phase 2 3, Phase 1/2 4, Phase 1 7) 2025: 45 trials (Observational 12, Not applicable 8, Phase 4 2, Phase 3 1, Phase 2 9, Phase 1/2 4, Phase 1 9)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 55
2025 45
2024 61
2023 49
2022 43
2021 62
2020 52
2019 41
2018 35
2017 33

Forecast of the full-year count, planned starts included, not rows of this table: about 61 trials starting in 2026 and about 47 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 89 trials still running at the 2026-10-09 snapshot; registered median of 22 months across 574 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Salivary Gland Diseases trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 114
Phase 1/2 48
Phase 2 182
Phase 2/3 14
Phase 3 85
Phase 4 49
Not applicable 249
Observational 214
Expanded access 1

How many Salivary Gland Diseases trials are recruiting? (10)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 45
Recruiting 104
Enrolling by invitation 5
Active, not recruiting 46
Available 1

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Salivary Gland Diseases trials? (7)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Cancer Institute (NCI) 43
GlaxoSmithKline 30
National Institute of Dental and Craniofacial Research (NIDCR) 20
Merck Sharp & Dohme LLC 19
Novartis Pharmaceuticals 14

Which drugs are being tested for Salivary Gland Diseases? (4)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
CETUXIMAB 12
(nab)-paclitaxel 10
PEMBROLIZUMAB 9
RITUXIMAB 7

Interventions as named in the registry (11)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Cisplatin 1 21
Docetetaxel 18
Radiation Therapy 17
Pilocarpine Nitrate 5% 12
or carboplatin 11

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Salivary Gland Diseases trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Dehydration 149 28
Gastroenteritis 148 24
Neutrophil count decreased 137 5
Pneumonia 137 31
Febrile convulsion 106 21

Which publications cover Salivary Gland Diseases? (28)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Dysfunction of the Salivary and Lacrimal Glands After Radioiodine Therapy for Thyroid Cancer: Results of the START Study After 6-Months of Follow-Up. Thyroid : official journal of the American Thyroid Association 2023 Yes
Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy. The Cochrane database of systematic reviews 2017 Yes
World Workshop on Oral Medicine VI: a systematic review of medication-induced salivary gland dysfunction: prevalence, diagnosis, and treatment. Clinical oral investigations 2015 Yes
AIUM practice guideline for the performance of ultrasound examinations of the head and neck. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2014 Yes
Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction. Proceedings of the National Academy of Sciences of the United States of America 2012 Yes

Sub-conditions in MeSH (8)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages