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Condition (MeSH)

Fatigue Syndrome, Chronic

ClinicalTrials.gov lists 258 trials for Fatigue Syndrome, Chronic or a narrower condition beneath it. US Department of Veterans Affairs has the most among industry and government lead sponsors, with 3.

MeSH D015673 Musculoskeletal Diseases C05 C10 C23 Listed by Orphanet as a rare disease
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Phase 1 Phase 1 9 Phase 1/2 Phase 1/2 5 Phase 2 Phase 2 25 Phase 2/3 Phase 2/3 6 Phase 3 Phase 3 7 Phase 4 Phase 4 10 Not applicable Not applicable 116 Observational Observational 79 Phase 1 Phase 1 9 Phase 1/2 Phase 1/2 5 Phase 2 Phase 2 25 Phase 2/3 Phase 2/3 6 Phase 3 Phase 3 7 Phase 4 Phase 4 10 Not applicable Not applicable 116 Observational Observational 79

Trials per phase (log scale)

1 more section with rows

258 of the 258 trials are tagged with Fatigue Syndrome, Chronic itself; the rest are tagged with a narrower condition beneath it.

Get the Fatigue Syndrome, Chronic report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Fatigue Syndrome, Chronic trials start? (27)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 26

1994: 1 trials (Observational 1) 1995: 2 trials (Observational 2) 1998: 2 trials (Observational 1, Phase 3 1) 1999: 2 trials (Observational 1, Not applicable 1) 2002: 1 trials (Phase 4 1) 2005: 1 trials (Not applicable 1) 2006: 1 trials (Phase 2/3 1) 2007: 9 trials (Observational 3, Not applicable 1, Phase 4 1, Phase 3 1, Phase 1/2 2, Phase 1 1) 2008: 6 trials (Observational 2, Not applicable 2, Phase 2/3 1, Phase 2 1) 2009: 7 trials (Observational 1, Not applicable 4, Phase 4 2) 2010: 8 trials (Not applicable 4, Phase 2 4) 2011: 9 trials (Observational 5, Not applicable 2, Phase 4 1, Phase 2 1) 2012: 5 trials (Observational 1, Not applicable 2, Phase 2 2) 2013: 13 trials (Observational 2, Not applicable 5, Phase 4 1, Phase 3 1, Phase 2/3 2, Phase 2 1, Phase 1/2 1) 2014: 8 trials (Observational 3, Not applicable 2, Phase 4 1, Phase 3 1, Phase 2/3 1) 2015: 5 trials (Observational 1, Not applicable 3, Phase 2 1) 2016: 11 trials (Observational 2, Not applicable 6, Phase 2 1, Phase 1 2) 2017: 7 trials (Observational 5, Not applicable 2) 2018: 6 trials (Observational 1, Not applicable 4, Phase 1/2 1) 2019: 15 trials (Observational 6, Not applicable 6, Phase 2 2, Phase 1 1) 2020: 15 trials (Observational 5, Not applicable 8, Phase 2 2) 2021: 26 trials (Observational 10, Not applicable 12, Phase 4 1, Phase 2 2, Phase 1 1) 2022: 20 trials (Observational 7, Not applicable 9, Phase 4 1, Phase 3 1, Phase 2 1, Phase 1 1) 2023: 23 trials (Observational 8, Not applicable 11, Phase 3 1, Phase 2 2, Phase 1 1) 2024: 21 trials (Observational 6, Not applicable 9, Phase 4 1, Phase 3 1, Phase 2 2, Phase 1/2 1, Phase 1 1) 2025: 12 trials (Not applicable 9, Phase 2/3 1, Phase 2 1, Phase 1 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 21
2025 12
2024 21
2023 23
2022 20
2021 26
2020 15
2019 15
2018 6
2017 7

Forecast of the full-year count, planned starts included, not rows of this table: about 25 trials starting in 2026 and about 20 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 32 trials still running at the 2026-10-09 snapshot; registered median of 23 months across 150 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Fatigue Syndrome, Chronic trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 9
Phase 1/2 5
Phase 2 25
Phase 2/3 6
Phase 3 7
Phase 4 10
Not applicable 116
Observational 79
Expanded access 1

How many Fatigue Syndrome, Chronic trials are recruiting? (10)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 11
Recruiting 39
Enrolling by invitation 3
Active, not recruiting 15
Completed 132

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Fatigue Syndrome, Chronic trials? (1)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
US Department of Veterans Affairs 3

Which drugs are being tested for Fatigue Syndrome, Chronic? (5)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
RITUXIMAB 5
Sodium Oxybate 3
Pyridostigmine 2
Rintatolimod 2
Duloxetine 2

Interventions as named in the registry (10)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Acupuncture 4
NaCl 0.9% NS 2
Hyperbaric Oxygen 2
Control (placebo) group 2
Blood Test 2

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Fatigue Syndrome, Chronic trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Hypotension 2 1
Tachycardia 2 1
Cardiological symptoms 1 1
Fluid buildup around heart 1 1
Hospitalization 1 1

Which publications cover Fatigue Syndrome, Chronic? (377)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.

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