Condition (MeSH)
Root Caries
ClinicalTrials.gov lists 39 trials for Root Caries or a narrower condition beneath it.
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Trials per phase (log scale)
39 of the 39 trials are tagged with Root Caries itself; the rest are tagged with a narrower condition beneath it.
When did Root Caries trials start? (12)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 3 trials are registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Not applicable
- Observational
Top of scale: 5
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 3 |
| 2025 | 4 |
| 2024 | 5 |
| 2023 | 5 |
| 2022 | 3 |
| 2021 | 5 |
| 2018 | 1 |
| 2017 | 5 |
| 2016 | 1 |
| 2014 | 2 |
Showing 10 of 12 earlier years.
No forecast is made for this condition: it averages 4.2 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 36 months from start to primary completion across 5 trials still running at the 2026-10-09 snapshot; registered median of 24 months across 13 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Root Caries trials in? (4)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 1 |
| Phase 1/2 | 1 |
| Not applicable | 33 |
| Observational | 4 |
How many Root Caries trials are recruiting? (6)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 12 |
| Recruiting | 1 |
| Active, not recruiting | 4 |
| Completed | 10 |
| Suspended | 1 |
Showing 5 of 6 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Root Caries trials? (3)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| 3Shape A/S | 1 |
| Faculty of Dental Medicine for Girls | 1 |
| Nobio Ltd. | 1 |
Which drugs are being tested for Root Caries? (3)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| aganirsen | 1 |
| cPMP | 1 |
| B | 1 |
Interventions as named in the registry (11)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Silver diamine Fluoride 38% | 5 |
| Resin modified glass ionomer cement | 2 |
| Double distilled water | 1 |
| 38% SDF | 1 |
| glass ionomer cement | 1 |
Showing 5 of 11 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which publications cover Root Caries? (58)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Update on the prevalence of untreated caries in the US adult population, 2017-2020. | Journal of the American Dental Association (1939) | 2022 | Yes |
| Clinical evidence for professionally applied fluoride therapy to prevent and arrest dental caries in older adults: A systematic review. | Journal of dentistry | 2022 | Yes |
| Clinical comparison of a micro-hybride resin-based composite and resin modified glass ionomer in the treatment of cervical caries lesions: 36-month, split-mouth, randomized clinical trial. | Odontology | 2021 | Yes |
| The burden of root caries: Updated perspectives and advances on management strategies. | Gerodontology | 2021 | Yes |
| Silver diamine fluoride treatment of active root caries lesions in older adults: A case series. | Journal of dentistry | 2021 | Yes |
Showing 5 of 58 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: serious adverse events in this condition's trials, prevalence, rare-disease identity, and sub-conditions in mesh.