Condition (MeSH)
Kallmann Syndrome
ClinicalTrials.gov lists 23 trials for Kallmann Syndrome or a narrower condition beneath it. Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) has the most among industry and government lead sponsors, with 3.
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Trials per phase
23 of the 23 trials are tagged with Kallmann Syndrome itself; the rest are tagged with a narrower condition beneath it.
When did Kallmann Syndrome trials start? (13)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 2
- Phase 4
- Not applicable
- Observational
Top of scale: 3
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2021 | 1 |
| 2018 | 3 |
| 2016 | 1 |
| 2015 | 1 |
| 2013 | 2 |
| 2012 | 3 |
| 2010 | 1 |
| 2009 | 2 |
| 2007 | 1 |
| 2002 | 1 |
Showing 10 of 13 earlier years.
No forecast is made for this condition: it averages 0.0 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 1 trial still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Kallmann Syndrome trials in? (5)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 5 |
| Phase 2 | 2 |
| Phase 4 | 3 |
| Not applicable | 4 |
| Observational | 9 |
How many Kallmann Syndrome trials are recruiting? (5)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Recruiting | 3 |
| Active, not recruiting | 1 |
| Completed | 11 |
| Terminated | 3 |
| Unknown status | 5 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Kallmann Syndrome trials? (3)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 3 |
| National Institute of Environmental Health Sciences (NIEHS) | 2 |
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 1 |
Which drugs are being tested for Kallmann Syndrome? (2)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| GnRH | 7 |
| Anastrozole | 1 |
Interventions as named in the registry (10)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Kisspeptin 112-121 | 2 |
| r-hCG | 2 |
| Sequential intervention for HH using HCG and FSH | 1 |
| Short withdrawal of testosterone, gonadotropins or estrogenic compounds (see below) | 1 |
| Testosteron | 1 |
Showing 5 of 10 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which publications cover Kallmann Syndrome? (20)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Flavor perception test: evaluation in patients with Kallmann syndrome. | Endocrine | 2016 | Yes |
| A novel syndrome caused by the E410K amino acid substitution in the neuronal β-tubulin isotype 3. | Brain : a journal of neurology | 2013 | Yes |
| Prioritizing genetic testing in patients with Kallmann syndrome using clinical phenotypes. | The Journal of clinical endocrinology and metabolism | 2013 | Yes |
| Genetic overlap in Kallmann syndrome, combined pituitary hormone deficiency, and septo-optic dysplasia. | The Journal of clinical endocrinology and metabolism | 2012 | Yes |
| CHD7 mutations in patients initially diagnosed with Kallmann syndrome--the clinical overlap with CHARGE syndrome. | Clinical genetics | 2009 | Yes |
Showing 5 of 20 publications.
Prevalence (12)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Kallmann syndrome | Point prevalence | 1-9 / 100 000 | Europe | Not stated | Exact |
| Kallmann syndrome | Annual incidence | 1-9 / 1 000 000 | Specific population | Not stated | Exact |
| Kallmann syndrome | Point prevalence | 1-9 / 100 000 | Europe | Not stated | Unspecified |
| Kallmann syndrome | Annual incidence | 1-9 / 100 000 | Finland | Not stated | Exact |
| Kallmann syndrome | Annual incidence | 1-9 / 100 000 | France | Not stated | Exact |
Showing 5 of 12 prevalence observations.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Kallmann syndrome | 478 | Exact | Orphadata Science knowledge files, Product 1 |
| Kallmann syndrome | 478 | Exact | Orphanet Rare Disease Ontology (ORDO) |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: serious adverse events in this condition's trials and sub-conditions in mesh.