Condition (MeSH)
Williams Syndrome
ClinicalTrials.gov lists 29 trials for Williams Syndrome or a narrower condition beneath it. National Heart, Lung, and Blood Institute (NHLBI) has the most among industry and government lead sponsors, with 3.
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Trials per phase
29 of the 29 trials are tagged with Williams Syndrome itself; the rest are tagged with a narrower condition beneath it.
When did Williams Syndrome trials start? (16)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 2
- Phase 4
- Not applicable
- Observational
Top of scale: 4
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 3 |
| 2025 | 1 |
| 2024 | 4 |
| 2023 | 1 |
| 2021 | 1 |
| 2019 | 2 |
| 2018 | 4 |
| 2017 | 2 |
| 2016 | 2 |
| 2014 | 2 |
Showing 10 of 16 earlier years.
No forecast is made for this condition: it averages 1.8 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 3 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Williams Syndrome trials in? (4)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 2 | 3 |
| Phase 4 | 2 |
| Not applicable | 7 |
| Observational | 17 |
How many Williams Syndrome trials are recruiting? (7)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 2 |
| Recruiting | 8 |
| Enrolling by invitation | 1 |
| Active, not recruiting | 1 |
| Completed | 13 |
Showing 5 of 7 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Williams Syndrome trials? (5)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | 3 |
| Sheba Medical Center | 2 |
| National Center for Research Resources (NCRR) | 1 |
| National Institute of Mental Health (NIMH) | 1 |
| National Institute of Neurological Disorders and Stroke (NINDS) | 1 |
Which drugs are being tested for Williams Syndrome? (3)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Clemastine | 1 |
| Buspirone | 1 |
| Calcium/Vitamin D | 1 |
Interventions as named in the registry (5)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| 2% Minoxidil | 1 |
| Physical examination and Urine and blood samples | 1 |
| methylphenidate, fluoxetin, risperidone | 1 |
| Urine and blood samples | 1 |
| Open Label Clemastine with a blinded randomize withdrawal | 1 |
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Williams Syndrome trials report? (2)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Flat foot | 1 | 1 |
| Strabismus correction | 1 | 1 |
Which publications cover Williams Syndrome? (24)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Dorsal visual stream and LIMK1: hemideletion, haplotype, and enduring effects in children with Williams syndrome. | Journal of neurodevelopmental disorders | 2023 | Yes |
| Social feedback enhances learning in Williams syndrome. | Scientific reports | 2023 | Yes |
| Heart Rate Variability Analysis May Identify Individuals With Williams-Beuren Syndrome at Risk of Sudden Death. | JACC. Clinical electrophysiology | 2023 | Yes |
| Neuronal deletion of Gtf2i, associated with Williams syndrome, causes behavioral and myelin alterations rescuable by a remyelinating drug. | Nature neuroscience | 2019 | Yes |
| Minoxidil versus placebo in the treatment of arterial wall hypertrophy in children with Williams Beuren Syndrome: a randomized controlled trial. | BMC pediatrics | 2019 | Yes |
Showing 5 of 24 publications.
Prevalence (12)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Williams syndrome | Point prevalence | 1-5 / 10 000 | Norway | Not stated | Exact |
| Williams syndrome | Prevalence at birth | 1-9 / 100 000 | Hong Kong | Not stated | Unspecified |
| Williams syndrome | Point prevalence | 1-5 / 10 000 | Norway | Not stated | Unspecified |
| Williams syndrome | Prevalence at birth | 1-9 / 100 000 | Hong Kong | Not stated | Exact |
| Williams syndrome | Point prevalence | 1-9 / 100 000 | Hong Kong | Not stated | Exact |
Showing 5 of 12 prevalence observations.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Williams syndrome | 904 | Exact | Orphanet Rare Disease Ontology (ORDO) |
| Williams syndrome | 904 | Exact | Orphadata Science knowledge files, Product 1 |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: sub-conditions in mesh.