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Condition (MeSH)

Fasciitis, Necrotizing

ClinicalTrials.gov lists 28 trials for Fasciitis, Necrotizing or a narrower condition beneath it.

MeSH D019115 Musculoskeletal Diseases C05 Listed by Orphanet as a rare disease
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Phase 2 Phase 2 1 Phase 3 Phase 3 1 Phase 4 Phase 4 1 Not applicable Not applicable 9 Observational Observational 16 Phase 2 Phase 2 1 Phase 3 Phase 3 1 Phase 4 Phase 4 1 Not applicable Not applicable 9 Observational Observational 16

Trials per phase

28 of the 28 trials are tagged with Fasciitis, Necrotizing itself; the rest are tagged with a narrower condition beneath it.

Get the Fasciitis, Necrotizing report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Fasciitis, Necrotizing trials start? (14)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 2
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 5

2000: 1 trials (Observational 1) 2005: 1 trials (Not applicable 1) 2007: 1 trials (Observational 1) 2009: 2 trials (Observational 1, Not applicable 1) 2012: 1 trials (Observational 1) 2013: 5 trials (Observational 5) 2014: 2 trials (Observational 1, Phase 2 1) 2015: 1 trials (Phase 3 1) 2017: 1 trials (Not applicable 1) 2020: 3 trials (Observational 1, Not applicable 2) 2021: 3 trials (Observational 2, Not applicable 1) 2023: 2 trials (Not applicable 1, Phase 4 1) 2025: 3 trials (Observational 1, Not applicable 2)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 2
2025 3
2023 2
2021 3
2020 3
2017 1
2015 1
2014 2
2013 5
2012 1

No forecast is made for this condition: it averages 1.8 trial starts a year over the five years to September, under the 5 a year the method needs.

Recruitment duration, a model prediction: 2 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Fasciitis, Necrotizing trials in? (5)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 2 1
Phase 3 1
Phase 4 1
Not applicable 9
Observational 16

How many Fasciitis, Necrotizing trials are recruiting? (6)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 3
Recruiting 3
Active, not recruiting 1
Completed 15
Terminated 1

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Fasciitis, Necrotizing trials? (3)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Atox Bio Ltd 1
Avita Medical 1
Kerecis Ltd. 1

Which drugs are being tested for Fasciitis, Necrotizing? (2)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Daptomycin 1
Honey 1

Interventions as named in the registry (9)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Hyperbaric Oxygen 2
NaCl 0.9% NS 1
Indocyanine Green dye 1
AB103 0.5 mg/kg 1
IVIG 1

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Fasciitis, Necrotizing trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Cardiac arrest 8 1
Acute kidney injury 6 1
Acute respiratory distress syndrome 6 1
Necrotizing soft tissue infection 6 1
Acute myocardial infarction 5 1

Which publications cover Fasciitis, Necrotizing? (36)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Vacuum-assisted closure versus conventional dressing in necrotizing fasciitis: a systematic review and meta-analysis. Journal of orthopaedic surgery and research 2023 Yes
Duration of Antibiotic Therapy in Necrotizing Soft Tissue Infections: Shorter is Safe. Surgical infections 2022 Yes
Estimating the Impact of Necrotizing Soft Tissue Infections in the United States: Incidence and Re-Admissions. Surgical infections 2021 Yes
Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2020 Yes
Necrotizing skin and soft-tissue infections in the intensive care unit. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2020 Yes

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.

Browse all condition evidence pages