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Condition (MeSH)

Hepatitis B, Chronic

ClinicalTrials.gov lists 859 trials for Hepatitis B, Chronic or a narrower condition beneath it. Hoffmann-La Roche has the most among industry and government lead sponsors, with 45.

MeSH D019694 Infections C01 C06 C23
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Phase 1 Phase 1 116 Phase 1/2 Phase 1/2 32 Phase 2 Phase 2 149 Phase 2/3 Phase 2/3 5 Phase 3 Phase 3 80 Phase 4 Phase 4 189 Not applicable Not applicable 86 Observational Observational 200 Phase 1 Phase 1 116 Phase 1/2 Phase 1/2 32 Phase 2 Phase 2 149 Phase 2/3 Phase 2/3 5 Phase 3 Phase 3 80 Phase 4 Phase 4 189 Not applicable Not applicable 86 Observational Observational 200

Trials per phase (log scale)

1 more section with rows

859 of the 859 trials are tagged with Hepatitis B, Chronic itself; the rest are tagged with a narrower condition beneath it.

Get the Hepatitis B, Chronic report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Hepatitis B, Chronic trials start? (29)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 57

1995: 1 trials (Phase 2 1) 1998: 1 trials (Phase 2/3 1) 2000: 2 trials (Phase 4 1, Phase 3 1) 2001: 5 trials (Phase 3 3, Phase 2 1, Phase 1 1) 2002: 10 trials (Observational 1, Not applicable 1, Phase 4 1, Phase 3 3, Phase 2 4) 2003: 10 trials (Observational 1, Phase 4 1, Phase 3 4, Phase 2 3, Phase 1/2 1) 2004: 14 trials (Observational 1, Not applicable 1, Phase 4 2, Phase 3 7, Phase 2 2, Phase 1/2 1) 2005: 21 trials (Observational 2, Not applicable 2, Phase 4 8, Phase 3 7, Phase 2 2) 2006: 16 trials (Observational 3, Phase 4 6, Phase 3 3, Phase 2 3, Phase 1 1) 2007: 25 trials (Observational 3, Not applicable 1, Phase 4 14, Phase 3 3, Phase 2 2, Phase 1/2 1, Phase 1 1) 2008: 29 trials (Observational 3, Not applicable 4, Phase 4 14, Phase 3 6, Phase 2 1, Phase 1/2 1) 2009: 35 trials (Observational 9, Not applicable 3, Phase 4 13, Phase 2 3, Phase 1/2 3, Phase 1 4) 2010: 29 trials (Observational 7, Not applicable 1, Phase 4 9, Phase 3 7, Phase 2 4, Phase 1 1) 2011: 34 trials (Observational 8, Not applicable 4, Phase 4 11, Phase 3 5, Phase 2 2, Phase 1/2 1, Phase 1 3) 2012: 37 trials (Observational 12, Phase 4 11, Phase 3 6, Phase 2 3, Phase 1/2 2, Phase 1 3) 2013: 31 trials (Observational 9, Not applicable 3, Phase 4 11, Phase 3 4, Phase 2 1, Phase 1/2 2, Phase 1 1) 2014: 32 trials (Observational 12, Not applicable 4, Phase 4 5, Phase 3 2, Phase 2/3 1, Phase 2 4, Phase 1/2 2, Phase 1 2) 2015: 47 trials (Observational 10, Not applicable 2, Phase 4 18, Phase 3 1, Phase 2 8, Phase 1/2 2, Phase 1 6) 2016: 43 trials (Observational 10, Not applicable 7, Phase 4 12, Phase 3 4, Phase 2/3 1, Phase 2 4, Phase 1 5) 2017: 36 trials (Observational 11, Not applicable 5, Phase 4 8, Phase 3 2, Phase 2 4, Phase 1/2 1, Phase 1 5) 2018: 36 trials (Observational 8, Not applicable 3, Phase 4 9, Phase 2 7, Phase 1/2 1, Phase 1 8) 2019: 33 trials (Observational 6, Not applicable 6, Phase 4 4, Phase 3 2, Phase 2 12, Phase 1/2 1, Phase 1 2) 2020: 50 trials (Observational 12, Not applicable 4, Phase 4 4, Phase 3 1, Phase 2 16, Phase 1/2 1, Phase 1 12) 2021: 47 trials (Observational 7, Not applicable 6, Phase 4 9, Phase 3 1, Phase 2 13, Phase 1 11) 2022: 57 trials (Observational 14, Not applicable 9, Phase 4 5, Phase 3 2, Phase 2 12, Phase 1/2 2, Phase 1 13) 2023: 43 trials (Observational 11, Not applicable 4, Phase 4 1, Phase 2 12, Phase 1/2 4, Phase 1 11) 2024: 53 trials (Observational 17, Not applicable 6, Phase 4 3, Phase 2 10, Phase 1/2 3, Phase 1 14) 2025: 35 trials (Observational 11, Not applicable 3, Phase 4 2, Phase 3 4, Phase 2/3 1, Phase 2 8, Phase 1/2 2, Phase 1 4)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 39
2025 35
2024 53
2023 43
2022 57
2021 47
2020 50
2019 33
2018 36
2017 36

Forecast of the full-year count, planned starts included, not rows of this table: about 49 trials starting in 2026 and about 44 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 63 trials still running at the 2026-10-09 snapshot; registered median of 27 months across 453 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Hepatitis B, Chronic trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 116
Phase 1/2 32
Phase 2 149
Phase 2/3 5
Phase 3 80
Phase 4 189
Not applicable 86
Observational 200
Expanded access 2

How many Hepatitis B, Chronic trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 39
Recruiting 75
Enrolling by invitation 5
Active, not recruiting 38
Completed 388

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Hepatitis B, Chronic trials? (8)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Hoffmann-La Roche 45
Gilead Sciences 34
GlaxoSmithKline 27
Bristol-Myers Squibb 24
Assembly Biosciences 17

Which drugs are being tested for Hepatitis B, Chronic? (9)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Entecavir 107
PEGinterferon alfa-2a 57
GS-7340 53
LAMIVUDINE 32
Tenofovir 17

Interventions as named in the registry (6)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
tenofovir disproxil fumarate 81
telbivudine/LDT600 36
adefovir dipivoxyl 21
PEGASYS [peginterferon alfa-2a] 16
PEG-IFN 15

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Hepatitis B, Chronic trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Alanine aminotransferase increased 88 19
Hepatic neoplasm malignant 74 9
Hepatocellular carcinoma 74 20
Hepatic encephalopathy 43 6
Hepatitis 41 11

Which publications cover Hepatitis B, Chronic? (894)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.

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