Condition (MeSH)
Sleep Bruxism
ClinicalTrials.gov lists 62 trials for Sleep Bruxism or a narrower condition beneath it. Aesyra SA has the most among industry and government lead sponsors, with 1.
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Trials per phase (log scale)
62 of the 62 trials are tagged with Sleep Bruxism itself; the rest are tagged with a narrower condition beneath it.
When did Sleep Bruxism trials start? (17)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 9
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 6 |
| 2025 | 9 |
| 2024 | 7 |
| 2023 | 4 |
| 2022 | 5 |
| 2021 | 5 |
| 2020 | 3 |
| 2019 | 5 |
| 2018 | 4 |
| 2017 | 4 |
Showing 10 of 17 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 8 trials starting in 2026 and about 8 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Recruitment duration, a model prediction: 3 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Sleep Bruxism trials in? (7)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 2 |
| Phase 1/2 | 2 |
| Phase 2 | 3 |
| Phase 3 | 1 |
| Phase 4 | 3 |
| Not applicable | 29 |
| Observational | 22 |
How many Sleep Bruxism trials are recruiting? (9)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 3 |
| Recruiting | 4 |
| Enrolling by invitation | 2 |
| Active, not recruiting | 1 |
| Completed | 35 |
Showing 5 of 9 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Sleep Bruxism trials? (1)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Aesyra SA | 1 |
Which drugs are being tested for Sleep Bruxism? (6)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| PrabotulinumtoxinA-Xvfs | 1 |
| Phytolacca decandra | 1 |
| ALS-L1023 | 1 |
| Opipramol | 1 |
| Botulinum Toxin | 1 |
Showing 5 of 6 drugs.
Interventions as named in the registry (9)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| type A botulinum toxin | 4 |
| Low Level Laser Therapy | 1 |
| Aromatherapy | 1 |
| Phyt.decandra + Melissa offic. | 1 |
| Physiotherapy | 1 |
Showing 5 of 9 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which publications cover Sleep Bruxism? (141)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Effect of Screen Time and Sugar Consumption Reduction on Sleep Bruxism in Children: A Randomised Clinical Trial. | Journal of oral rehabilitation | 2025 | Yes |
| Jaw Exercise Versus Jaw & Posture Exercise Therapies in Comparison to Occlusal Splint Effectiveness in Probable Sleep Bruxism: A Randomised Controlled Study. | Journal of oral rehabilitation | 2025 | Yes |
| Relationship between pain, quality of sleep, sleep bruxism and patients' personality among individuals with reported orofacial pain. | Scientific reports | 2025 | Yes |
| Standardised Tool for the Assessment of Bruxism. | Journal of oral rehabilitation | 2024 | Yes |
| Comparative analysis of different types of occlusal splints for the management of sleep bruxism: a systematic review. | BMC oral health | 2024 | Yes |
Showing 5 of 141 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: serious adverse events in this condition's trials, prevalence, rare-disease identity, and sub-conditions in mesh.