Condition (MeSH)
Osteoarthritis, Knee
ClinicalTrials.gov lists 3,185 trials for Osteoarthritis, Knee or a narrower condition beneath it. Zimmer Biomet has the most among industry and government lead sponsors, with 22.
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Trials per phase (log scale)
3,185 of the 3,185 trials are tagged with Osteoarthritis, Knee itself; the rest are tagged with a narrower condition beneath it.
When did Osteoarthritis, Knee trials start? (31)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 9 trials are registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 273
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 171 |
| 2025 | 232 |
| 2024 | 227 |
| 2023 | 273 |
| 2022 | 231 |
| 2021 | 242 |
| 2020 | 198 |
| 2019 | 206 |
| 2018 | 215 |
| 2017 | 170 |
Showing 10 of 31 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 210 trials starting in 2026 and about 220 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 13 percent and ran about 12 percent low against the count later registered; forecasts made before the year began were off by about 19 percent and ran about 17 percent low against the count later registered, and had about the same error as repeating last year's count. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 282 trials still running at the 2026-10-09 snapshot; registered median of 16 months across 1,957 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Osteoarthritis, Knee trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 118 |
| Phase 1/2 | 78 |
| Phase 2 | 226 |
| Phase 2/3 | 44 |
| Phase 3 | 213 |
| Phase 4 | 226 |
| Not applicable | 1,799 |
| Observational | 481 |
How many Osteoarthritis, Knee trials are recruiting? (9)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 156 |
| Recruiting | 298 |
| Enrolling by invitation | 20 |
| Active, not recruiting | 133 |
| Completed | 1,781 |
Showing 5 of 9 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Osteoarthritis, Knee trials? (4)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Zimmer Biomet | 22 |
| VA Office of Research and Development | 17 |
| Pacira Pharmaceuticals, Inc | 16 |
| Pfizer | 15 |
Which drugs are being tested for Osteoarthritis, Knee? (3)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Corticosteroid | 20 |
| Duloxetine | 16 |
| +/- Bupivacaine HCl | 14 |
Interventions as named in the registry (12)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| [PRP] platelet rich plasma | 55 |
| Exercise | 51 |
| Hyaluronic acid 1% | 47 |
| total knee arthroplasty | 39 |
| "celecoxib", "Celebrex®" | 34 |
Showing 5 of 12 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Osteoarthritis, Knee trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Osteoarthritis | 347 | 26 |
| Rapidly progressive osteoarthritis | 332 | 5 |
| Arthralgia | 247 | 20 |
| Knee arthroplasty | 156 | 10 |
| Pneumonia | 75 | 30 |
Showing 5 of 10 adverse events.
Which publications cover Osteoarthritis, Knee? (3,772)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Assessing clinical and cost effectiveness of total versus partial knee replacement (TOPKAT): 10-year follow-up of a multicentre, randomised controlled trial. | The Lancet. Rheumatology | 2026 | Yes |
| A phase III, randomised, double-blind, multi-dose, placebo- and naproxen-controlled study to evaluate the efficacy and safety of fasinumab in patients with pain due to osteoarthritis of the knee or hip. | RMD open | 2026 | Yes |
| The Effect of Foot Reflexology and Knee Massage With Black Cumin Seed Oil on Knee Osteoarthritis Symptoms. | Holistic nursing practice | 2026 | Yes |
| Dry cupping therapy has no effect on pain, function, or quality of life in women with knee osteoarthritis: Randomized placebo-controlled trial. | Brazilian journal of physical therapy | 2026 | Yes |
| Associations of medial collateral ligament and cartilage thickness with clinical outcomes in medial knee osteoarthritis: a cross-sectional study. | Clinical rheumatology | 2026 | Yes |
Showing 5 of 3,772 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.