Condition (MeSH)
Myotonic Disorders
ClinicalTrials.gov lists 154 trials for Myotonic Disorders or a narrower condition beneath it. Lupin Ltd. has the most among industry and government lead sponsors, with 8.
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Trials per phase (log scale)
18 of the 154 trials are tagged with Myotonic Disorders itself; the rest are tagged with a narrower condition beneath it.
When did Myotonic Disorders trials start? (27)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Not applicable
- Observational
Top of scale: 19
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 9 |
| 2025 | 19 |
| 2024 | 15 |
| 2023 | 10 |
| 2022 | 10 |
| 2021 | 19 |
| 2020 | 9 |
| 2019 | 4 |
| 2018 | 2 |
| 2017 | 3 |
Showing 10 of 27 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 12 trials starting in 2026 and about 16 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 21 trials still running at the 2026-10-09 snapshot; registered median of 25 months across 74 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Myotonic Disorders trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 5 |
| Phase 1/2 | 8 |
| Phase 2 | 9 |
| Phase 2/3 | 4 |
| Phase 3 | 16 |
| Not applicable | 39 |
| Observational | 72 |
| Expanded access | 1 |
How many Myotonic Disorders trials are recruiting? (9)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 5 |
| Recruiting | 43 |
| Enrolling by invitation | 10 |
| Active, not recruiting | 6 |
| Available | 1 |
Showing 5 of 9 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Myotonic Disorders trials? (5)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Lupin Ltd. | 8 |
| Avidity Biosciences, Inc. | 5 |
| AMO Pharma Limited | 4 |
| Dyne Therapeutics | 3 |
| PepGen Inc | 3 |
Which drugs are being tested for Myotonic Disorders? (3)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Mexiletine | 8 |
| Tideglusib | 4 |
| DYNE-101 | 2 |
Interventions as named in the registry (12)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| MRI | 3 |
| AOC 1001 | 3 |
| PGN-EDODM1 | 2 |
| VX-670 | 2 |
| Exercise | 2 |
Showing 5 of 12 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Myotonic Disorders trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Fall | 4 | 1 |
| Respiratory Failure | 4 | 2 |
| Acute Inflammation of Gallbladder | 1 | 1 |
| Bundle Branch Block Left | 1 | 1 |
| Chest Pain | 1 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Myotonic Disorders? (8)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Open-label trial of ranolazine for the treatment of paramyotonia congenita. | Muscle & nerve | 2019 | Yes |
| Effect of Mexiletine on Muscle Stiffness in Patients With Nondystrophic Myotonia Evaluated Using Aggregated N-of-1 Trials. | JAMA | 2018 | Yes |
| The antimyotonic effect of lamotrigine in non-dystrophic myotonias: a double-blind randomized study. | Brain : a journal of neurology | 2017 | Yes |
| Clinical aspects, molecular pathomechanisms and management of myotonic dystrophies. | Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology | 2013 | Yes |
| The myotonic dystrophies: molecular, clinical, and therapeutic challenges. | The Lancet. Neurology | 2012 | Yes |
Showing 5 of 8 publications.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Myotonic syndrome | 206970 | Exact | Orphanet Rare Disease Ontology (ORDO) |
| Myotonic syndrome | 206970 | Exact | Orphadata Science knowledge files, Product 1 |
Sub-conditions in MeSH (2)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence.