Condition (MeSH)
Erdheim-Chester Disease
ClinicalTrials.gov lists 22 trials for Erdheim-Chester Disease or a narrower condition beneath it.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase
22 of the 22 trials are tagged with Erdheim-Chester Disease itself; the rest are tagged with a narrower condition beneath it.
When did Erdheim-Chester Disease trials start? (14)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Not applicable
- Observational
Top of scale: 3
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 1 |
| 2025 | 1 |
| 2024 | 1 |
| 2023 | 1 |
| 2022 | 1 |
| 2021 | 3 |
| 2020 | 2 |
| 2019 | 3 |
| 2018 | 1 |
| 2017 | 1 |
Showing 10 of 14 earlier years.
No forecast is made for this condition: it averages 1.4 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 4 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Erdheim-Chester Disease trials in? (6)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 3 |
| Phase 1/2 | 1 |
| Phase 2 | 5 |
| Phase 2/3 | 2 |
| Not applicable | 1 |
| Observational | 10 |
How many Erdheim-Chester Disease trials are recruiting? (6)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Recruiting | 10 |
| Active, not recruiting | 1 |
| Completed | 2 |
| Terminated | 3 |
| Withdrawn | 2 |
Showing 5 of 6 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Erdheim-Chester Disease trials? (5)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| CENTOGENE GmbH Rostock | 1 |
| Haihe Biopharma Co., Ltd. | 1 |
| National Cancer Institute (NCI) | 1 |
| National Human Genome Research Institute (NHGRI) | 1 |
| Shanghai Henlius Biotech | 1 |
Which drugs are being tested for Erdheim-Chester Disease? (3)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| GSK1120212 | 2 |
| Cobimetinib | 2 |
| Dabrafenib | 2 |
Interventions as named in the registry (12)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| HH2710 | 1 |
| Bone marrow aspiration | 1 |
| Vermurafenib | 1 |
| Positron Emission Tomography (PET) | 1 |
| Biopsy | 1 |
Showing 5 of 12 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Erdheim-Chester Disease trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Intestinal obstruction | 2 | 1 |
| Pyrexia | 2 | 1 |
| Small intestinal obstruction | 2 | 1 |
| Anemia | 1 | 1 |
| Central serous chorioretinopathy | 1 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Erdheim-Chester Disease? (16)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Ophthalmologic Findings in Pediatric Erdheim-Chester Disease: A Literature Review With a Novel Case Report. | Ophthalmic plastic and reconstructive surgery | 2023 | Yes |
| Myocarditis as a manifestation of Erdheim-Chester Disease: successful use of anti- IL1 and BRAF inhibitor combination therapy. | Scandinavian journal of rheumatology | 2022 | Yes |
| <sup>18</sup>F-FDG PET/CT versus anatomic imaging for evaluating disease extent and clinical trial eligibility in Erdheim-Chester disease: results from 50 patients in a registry study. | European journal of nuclear medicine and molecular imaging | 2021 | Yes |
| Erdheim-Chester disease: consensus recommendations for evaluation, diagnosis, and treatment in the molecular era. | Blood | 2020 | Yes |
| Molecular Profiling of Tumor Tissue and Plasma Cell-Free DNA from Patients with Non-Langerhans Cell Histiocytosis. | Molecular cancer therapeutics | 2019 | Yes |
Showing 5 of 16 publications.
Prevalence (6)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Erdheim-Chester disease | Point prevalence | <1 / 1 000 000 | Worldwide | Not stated | Exact |
| Erdheim-Chester disease | Cases families | Worldwide | Not stated | Exact | |
| Erdheim-Chester disease | Cases families | Worldwide | Not stated | Exact | |
| Erdheim-Chester disease | Point prevalence | <1 / 1 000 000 | Worldwide | Not stated | Exact |
| Erdheim-Chester disease | Point prevalence | <1 / 1 000 000 | Worldwide | Not stated | Unspecified |
Showing 5 of 6 prevalence observations.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Erdheim-Chester disease | 35687 | Exact | Orphanet Rare Disease Ontology (ORDO) |
| Erdheim-Chester disease | 35687 | Exact | Orphadata Science knowledge files, Product 1 |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: sub-conditions in mesh.