Skip to content
Pharma Observatory a Scientist.com platform

Condition (MeSH)

Stress Disorders, Traumatic

ClinicalTrials.gov lists 2,901 trials for Stress Disorders, Traumatic or a narrower condition beneath it. VA Office of Research and Development has the most among industry and government lead sponsors, with 265.

MeSH D040921 Mental Disorders F03
Email me this page as a PDF

Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Phase 1 Phase 1 128 Phase 1/2 Phase 1/2 48 Phase 2 Phase 2 248 Phase 2/3 Phase 2/3 42 Phase 3 Phase 3 93 Phase 4 Phase 4 110 Not applicable Not applicable 1,801 Observational Observational 430 Phase 1 Phase 1 128 Phase 1/2 Phase 1/2 48 Phase 2 Phase 2 248 Phase 2/3 Phase 2/3 42 Phase 3 Phase 3 93 Phase 4 Phase 4 110 Not applicable Not applicable 1,801 Observational Observational 430

Trials per phase (log scale)

1 more section with rows

118 of the 2,901 trials are tagged with Stress Disorders, Traumatic itself; the rest are tagged with a narrower condition beneath it.

Get the Stress Disorders, Traumatic report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Stress Disorders, Traumatic trials start? (32)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 22 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 207

1991: 1 trials (Observational 1) 1994: 1 trials (Not applicable 1) 1997: 4 trials (Observational 1, Not applicable 2, Phase 1/2 1) 1998: 1 trials (Observational 1) 1999: 4 trials (Observational 1, Not applicable 1, Phase 3 1, Phase 1 1) 2000: 7 trials (Observational 3, Not applicable 2, Phase 4 1, Phase 3 1) 2001: 12 trials (Observational 3, Not applicable 2, Phase 4 4, Phase 3 2, Phase 2 1) 2002: 20 trials (Observational 2, Not applicable 6, Phase 4 3, Phase 3 3, Phase 2/3 3, Phase 2 1, Phase 1/2 1, Phase 1 1) 2003: 21 trials (Observational 2, Not applicable 5, Phase 4 7, Phase 3 4, Phase 2 2, Phase 1/2 1) 2004: 32 trials (Observational 3, Not applicable 12, Phase 4 4, Phase 3 6, Phase 2/3 1, Phase 2 3, Phase 1/2 2, Phase 1 1) 2005: 37 trials (Observational 10, Not applicable 12, Phase 4 3, Phase 3 4, Phase 2/3 1, Phase 2 4, Phase 1/2 2, Phase 1 1) 2006: 39 trials (Observational 5, Not applicable 17, Phase 4 5, Phase 3 2, Phase 2/3 1, Phase 2 6, Phase 1 3) 2007: 41 trials (Observational 7, Not applicable 15, Phase 4 3, Phase 3 1, Phase 2/3 1, Phase 2 9, Phase 1 5) 2008: 89 trials (Observational 14, Not applicable 42, Phase 4 6, Phase 3 4, Phase 2/3 4, Phase 2 9, Phase 1/2 2, Phase 1 8) 2009: 79 trials (Observational 8, Not applicable 41, Phase 4 8, Phase 3 3, Phase 2/3 1, Phase 2 9, Phase 1/2 3, Phase 1 6) 2010: 89 trials (Observational 17, Not applicable 41, Phase 4 4, Phase 3 8, Phase 2/3 2, Phase 2 13, Phase 1/2 1, Phase 1 3) 2011: 90 trials (Observational 23, Not applicable 40, Phase 4 4, Phase 3 6, Phase 2/3 1, Phase 2 9, Phase 1/2 2, Phase 1 5) 2012: 123 trials (Observational 20, Not applicable 68, Phase 4 7, Phase 3 5, Phase 2/3 2, Phase 2 9, Phase 1/2 4, Phase 1 8) 2013: 93 trials (Observational 14, Not applicable 57, Phase 4 6, Phase 3 2, Phase 2/3 1, Phase 2 9, Phase 1/2 3, Phase 1 1) 2014: 86 trials (Observational 9, Not applicable 64, Phase 4 2, Phase 2/3 2, Phase 2 3, Phase 1/2 2, Phase 1 4) 2015: 94 trials (Observational 10, Not applicable 66, Phase 4 1, Phase 2/3 2, Phase 2 9, Phase 1/2 1, Phase 1 5) 2016: 123 trials (Observational 16, Not applicable 80, Phase 4 6, Phase 3 2, Phase 2/3 3, Phase 2 7, Phase 1/2 4, Phase 1 5) 2017: 113 trials (Observational 11, Not applicable 79, Phase 4 4, Phase 3 4, Phase 2/3 1, Phase 2 8, Phase 1/2 1, Phase 1 5) 2018: 124 trials (Observational 23, Not applicable 81, Phase 4 3, Phase 3 5, Phase 2 7, Phase 1/2 2, Phase 1 3) 2019: 171 trials (Observational 23, Not applicable 118, Phase 4 6, Phase 3 4, Phase 2/3 1, Phase 2 9, Phase 1/2 3, Phase 1 7) 2020: 181 trials (Observational 43, Not applicable 118, Phase 4 6, Phase 3 3, Phase 2/3 1, Phase 2 5, Phase 1 5) 2021: 196 trials (Observational 33, Not applicable 125, Phase 4 1, Phase 3 4, Phase 2/3 5, Phase 2 18, Phase 1/2 2, Phase 1 8) 2022: 206 trials (Observational 36, Not applicable 140, Phase 4 3, Phase 3 2, Phase 2 17, Phase 1/2 2, Phase 1 6) 2023: 179 trials (Observational 23, Not applicable 127, Phase 4 2, Phase 3 3, Phase 2/3 2, Phase 2 13, Phase 1/2 3, Phase 1 6) 2024: 201 trials (Observational 20, Not applicable 146, Phase 4 2, Phase 3 5, Phase 2/3 2, Phase 2 16, Phase 1/2 2, Phase 1 8) 2025: 207 trials (Observational 22, Not applicable 150, Phase 4 3, Phase 2/3 1, Phase 2 20, Phase 1/2 2, Phase 1 9)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 204
2025 207
2024 201
2023 179
2022 206
2021 196
2020 181
2019 171
2018 124
2017 113

Showing 10 of 32 earlier years.

Start your 14-day trial Email me all 32 earlier years as a PDF

Forecast of the full-year count, planned starts included, not rows of this table: about 230 trials starting in 2026 and about 220 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 13 percent and ran about 12 percent low against the count later registered; forecasts made before the year began were off by about 19 percent and ran about 17 percent low against the count later registered, and had about the same error as repeating last year's count. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 391 trials still running at the 2026-10-09 snapshot; registered median of 28 months across 1,796 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Stress Disorders, Traumatic trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 128
Phase 1/2 48
Phase 2 248
Phase 2/3 42
Phase 3 93
Phase 4 110
Not applicable 1,801
Observational 430
Expanded access 1

How many Stress Disorders, Traumatic trials are recruiting? (10)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 136
Recruiting 423
Enrolling by invitation 41
Active, not recruiting 93
Completed 1,641

Showing 5 of 10 statuses.

Start your 14-day trial Email me all 10 statuses as a PDF

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Stress Disorders, Traumatic trials? (2)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
VA Office of Research and Development 265
US Department of Veterans Affairs 56

Which drugs are being tested for Stress Disorders, Traumatic? (3)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
3,4 Methylenedioxymethamphetamine 36
PMI-150 (intranasal ketamine) 32
D-Cycloserine 13

Interventions as named in the registry (12)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Treatment As Usual 77
Propranolol PO 27
Sertralin 24
T.Prazosin 24
IV Psilocybin 19

Showing 5 of 12 interventions.

Start your 14-day trial Email me all 12 interventions as a PDF

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Stress Disorders, Traumatic trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Suicidal ideation 150 14
Suicide Intent 107 1
Hospitalization 84 18
Life Threatening Experience or Trauma 61 1
Other Hospitalization 54 1

Showing 5 of 10 adverse events.

Start your 14-day trial Email me all 10 adverse events as a PDF

Which publications cover Stress Disorders, Traumatic? (37)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Mediators and Moderators of Active Music Engagement to Reduce Traumatic Stress Symptoms and Improve Well-being in Parents of Young Children With Cancer. Integrative cancer therapies 2023 Yes
The AURORA Study: a longitudinal, multimodal library of brain biology and function after traumatic stress exposure. Molecular psychiatry 2020 Yes
Symptoms of Anxiety, Depression, and Peritraumatic Dissociation in Critical Care Clinicians Managing Patients with COVID-19. A Cross-Sectional Study. American journal of respiratory and critical care medicine 2020 Yes
Brief interventions for young adults who use drugs: The moderating effects of resilience and trauma. Journal of substance abuse treatment 2019 Yes
Prescription Opioid Misuse After a Recent Sexual Assault: A Randomized Clinical Trial of a Video Intervention. The American journal on addictions 2019 Yes

Showing 5 of 37 publications.

Start your 14-day trial Email me all 37 publications as a PDF

Sub-conditions in MeSH (5)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages