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Condition (MeSH)

Trauma and Stressor Related Disorders

ClinicalTrials.gov lists 2,999 trials for Trauma and Stressor Related Disorders or a narrower condition beneath it. VA Office of Research and Development has the most among industry and government lead sponsors, with 266.

MeSH D000068099 Mental Disorders F03
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Phase 1 Phase 1 131 Phase 1/2 Phase 1/2 49 Phase 2 Phase 2 252 Phase 2/3 Phase 2/3 43 Phase 3 Phase 3 95 Phase 4 Phase 4 112 Not applicable Not applicable 1,872 Observational Observational 444 Phase 1 Phase 1 131 Phase 1/2 Phase 1/2 49 Phase 2 Phase 2 252 Phase 2/3 Phase 2/3 43 Phase 3 Phase 3 95 Phase 4 Phase 4 112 Not applicable Not applicable 1,872 Observational Observational 444

Trials per phase (log scale)

1 more section with rows

53 of the 2,999 trials are tagged with Trauma and Stressor Related Disorders itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Trauma and Stressor Related Disorders trials start? (32)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 23 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 222

1991: 1 trials (Observational 1) 1994: 1 trials (Not applicable 1) 1997: 4 trials (Observational 1, Not applicable 2, Phase 1/2 1) 1998: 1 trials (Observational 1) 1999: 5 trials (Observational 1, Not applicable 1, Phase 3 2, Phase 1 1) 2000: 7 trials (Observational 3, Not applicable 2, Phase 4 1, Phase 3 1) 2001: 12 trials (Observational 3, Not applicable 2, Phase 4 4, Phase 3 2, Phase 2 1) 2002: 20 trials (Observational 2, Not applicable 6, Phase 4 3, Phase 3 3, Phase 2/3 3, Phase 2 1, Phase 1/2 1, Phase 1 1) 2003: 21 trials (Observational 2, Not applicable 5, Phase 4 7, Phase 3 4, Phase 2 2, Phase 1/2 1) 2004: 32 trials (Observational 3, Not applicable 12, Phase 4 4, Phase 3 6, Phase 2/3 1, Phase 2 3, Phase 1/2 2, Phase 1 1) 2005: 37 trials (Observational 10, Not applicable 12, Phase 4 3, Phase 3 4, Phase 2/3 1, Phase 2 4, Phase 1/2 2, Phase 1 1) 2006: 39 trials (Observational 5, Not applicable 17, Phase 4 5, Phase 3 2, Phase 2/3 1, Phase 2 6, Phase 1 3) 2007: 44 trials (Observational 8, Not applicable 16, Phase 4 3, Phase 3 1, Phase 2/3 1, Phase 2 9, Phase 1 6) 2008: 89 trials (Observational 14, Not applicable 42, Phase 4 6, Phase 3 4, Phase 2/3 4, Phase 2 9, Phase 1/2 2, Phase 1 8) 2009: 81 trials (Observational 8, Not applicable 42, Phase 4 8, Phase 3 3, Phase 2/3 1, Phase 2 9, Phase 1/2 4, Phase 1 6) 2010: 92 trials (Observational 18, Not applicable 42, Phase 4 4, Phase 3 8, Phase 2/3 2, Phase 2 13, Phase 1/2 1, Phase 1 4) 2011: 90 trials (Observational 23, Not applicable 40, Phase 4 4, Phase 3 6, Phase 2/3 1, Phase 2 9, Phase 1/2 2, Phase 1 5) 2012: 123 trials (Observational 20, Not applicable 68, Phase 4 7, Phase 3 5, Phase 2/3 2, Phase 2 9, Phase 1/2 4, Phase 1 8) 2013: 96 trials (Observational 14, Not applicable 60, Phase 4 6, Phase 3 2, Phase 2/3 1, Phase 2 9, Phase 1/2 3, Phase 1 1) 2014: 88 trials (Observational 9, Not applicable 66, Phase 4 2, Phase 2/3 2, Phase 2 3, Phase 1/2 2, Phase 1 4) 2015: 101 trials (Observational 11, Not applicable 71, Phase 4 1, Phase 2/3 2, Phase 2 10, Phase 1/2 1, Phase 1 5) 2016: 127 trials (Observational 16, Not applicable 84, Phase 4 6, Phase 3 2, Phase 2/3 3, Phase 2 7, Phase 1/2 4, Phase 1 5) 2017: 117 trials (Observational 11, Not applicable 83, Phase 4 4, Phase 3 4, Phase 2/3 1, Phase 2 8, Phase 1/2 1, Phase 1 5) 2018: 130 trials (Observational 25, Not applicable 85, Phase 4 3, Phase 3 5, Phase 2 7, Phase 1/2 2, Phase 1 3) 2019: 173 trials (Observational 23, Not applicable 120, Phase 4 6, Phase 3 4, Phase 2/3 1, Phase 2 9, Phase 1/2 3, Phase 1 7) 2020: 184 trials (Observational 44, Not applicable 120, Phase 4 6, Phase 3 3, Phase 2/3 1, Phase 2 5, Phase 1 5) 2021: 207 trials (Observational 36, Not applicable 132, Phase 4 2, Phase 3 4, Phase 2/3 5, Phase 2 18, Phase 1/2 2, Phase 1 8) 2022: 214 trials (Observational 36, Not applicable 146, Phase 4 3, Phase 3 3, Phase 2 18, Phase 1/2 2, Phase 1 6) 2023: 188 trials (Observational 25, Not applicable 133, Phase 4 2, Phase 3 3, Phase 2/3 3, Phase 2 13, Phase 1/2 3, Phase 1 6) 2024: 206 trials (Observational 21, Not applicable 150, Phase 4 2, Phase 3 5, Phase 2/3 2, Phase 2 16, Phase 1/2 2, Phase 1 8) 2025: 222 trials (Observational 23, Not applicable 161, Phase 4 4, Phase 2/3 1, Phase 2 22, Phase 1/2 2, Phase 1 9)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 212
2025 222
2024 206
2023 188
2022 214
2021 207
2020 184
2019 173
2018 130
2017 117

Showing 10 of 32 earlier years.

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Forecast of the full-year count, planned starts included, not rows of this table: about 240 trials starting in 2026 and about 230 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 13 percent and ran about 12 percent low against the count later registered; forecasts made before the year began were off by about 19 percent and ran about 17 percent low against the count later registered, and had about the same error as repeating last year's count. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 412 trials still running at the 2026-10-09 snapshot; registered median of 28 months across 1,847 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Trauma and Stressor Related Disorders trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 131
Phase 1/2 49
Phase 2 252
Phase 2/3 43
Phase 3 95
Phase 4 112
Not applicable 1,872
Observational 444
Expanded access 1

How many Trauma and Stressor Related Disorders trials are recruiting? (10)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 142
Recruiting 445
Enrolling by invitation 43
Active, not recruiting 95
Completed 1,686

Showing 5 of 10 statuses.

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Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Trauma and Stressor Related Disorders trials? (2)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
VA Office of Research and Development 266
US Department of Veterans Affairs 56

Which drugs are being tested for Trauma and Stressor Related Disorders? (3)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
3,4 Methylenedioxymethamphetamine 37
PMI-150 (intranasal ketamine) 32
D-Cycloserine 13

Interventions as named in the registry (12)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Treatment As Usual 79
Propranolol PO 27
Sertralin 24
T.Prazosin 24
IV Psilocybin 19

Showing 5 of 12 interventions.

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These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Trauma and Stressor Related Disorders trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Suicidal ideation 150 14
Suicide Intent 107 1
Hospitalization 84 18
Life Threatening Experience or Trauma 61 1
Other Hospitalization 54 1

Showing 5 of 10 adverse events.

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Which publications cover Trauma and Stressor Related Disorders? (8)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Peripheral adiponectin levels in anxiety, mood, trauma- and stressor-related disorders: A systematic review and meta-analysis. Journal of affective disorders 2020 Yes
The Gut Microbiome and Mental Health: Implications for Anxiety- and Trauma-Related Disorders. Omics : a journal of integrative biology 2018 Yes
Treatment of depression, anxiety, and trauma-related disorders during the perinatal period: A systematic review. Clinical psychology review 2018 Yes
The art and skill of delivering culturally responsive trauma-focused cognitive behavioral therapy in Tanzania and Kenya. Psychological trauma : theory, research, practice and policy 2017 Yes
Preventing sickness absenteeism among employees with common mental disorders or stress-related symptoms at work: Design of a cluster randomized controlled trial of a problem-solving based intervention versus care-as-usual conducted at the Occupational Health Services. BMC public health 2017 Yes

Showing 5 of 8 publications.

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Sub-conditions in MeSH (3)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

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