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Condition (MeSH)

Adrenogenital Syndrome

ClinicalTrials.gov lists 176 trials for Adrenogenital Syndrome or a narrower condition beneath it. Neurocrine UK Limited has the most among industry and government lead sponsors, with 8.

MeSH D047808 Urogenital Diseases C12 C16 C19 Listed by Orphanet as a rare disease
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Phase 1 Phase 1 12 Phase 1/2 Phase 1/2 6 Phase 2 Phase 2 31 Phase 2/3 Phase 2/3 2 Phase 3 Phase 3 11 Phase 4 Phase 4 12 Not applicable Not applicable 33 Observational Observational 69 Phase 1 Phase 1 12 Phase 1/2 Phase 1/2 6 Phase 2 Phase 2 31 Phase 2/3 Phase 2/3 2 Phase 3 Phase 3 11 Phase 4 Phase 4 12 Not applicable Not applicable 33 Observational Observational 69

Trials per phase (log scale)

2 of the 176 trials are tagged with Adrenogenital Syndrome itself; the rest are tagged with a narrower condition beneath it.

Get the Adrenogenital Syndrome report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Adrenogenital Syndrome trials start? (27)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 12

1993: 1 trials (Phase 2 1) 1995: 1 trials (Phase 3 1) 1997: 1 trials (Phase 3 1) 2000: 1 trials (Observational 1) 2001: 2 trials (Observational 1, Not applicable 1) 2004: 3 trials (Observational 2, Phase 4 1) 2006: 5 trials (Observational 2, Not applicable 3) 2007: 6 trials (Observational 3, Not applicable 2, Phase 1/2 1) 2008: 7 trials (Observational 5, Phase 2 1, Phase 1 1) 2009: 3 trials (Observational 1, Not applicable 1, Phase 4 1) 2010: 4 trials (Observational 1, Not applicable 1, Phase 3 1, Phase 1 1) 2011: 7 trials (Observational 3, Not applicable 2, Phase 1 2) 2012: 8 trials (Observational 4, Not applicable 1, Phase 2/3 1, Phase 2 1, Phase 1 1) 2013: 8 trials (Observational 3, Not applicable 1, Phase 4 1, Phase 2 3) 2014: 6 trials (Not applicable 4, Phase 4 1, Phase 1/2 1) 2015: 6 trials (Observational 2, Not applicable 1, Phase 2 2, Phase 1 1) 2016: 10 trials (Observational 2, Not applicable 3, Phase 4 1, Phase 3 2, Phase 2 1, Phase 1 1) 2017: 5 trials (Not applicable 1, Phase 4 1, Phase 2 2, Phase 1 1) 2018: 11 trials (Observational 4, Not applicable 1, Phase 3 1, Phase 2 4, Phase 1/2 1) 2019: 9 trials (Observational 2, Not applicable 2, Phase 4 1, Phase 2 2, Phase 1 2) 2020: 9 trials (Observational 5, Phase 4 1, Phase 3 1, Phase 2 2) 2021: 12 trials (Observational 6, Not applicable 1, Phase 3 1, Phase 2 2, Phase 1/2 1, Phase 1 1) 2022: 7 trials (Observational 4, Phase 3 2, Phase 1/2 1) 2023: 7 trials (Observational 2, Not applicable 2, Phase 2 3) 2024: 7 trials (Observational 6, Not applicable 1) 2025: 7 trials (Observational 1, Not applicable 2, Phase 4 1, Phase 3 1, Phase 2 2)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 20
2025 7
2024 7
2023 7
2022 7
2021 12
2020 9
2019 9
2018 11
2017 5

Forecast of the full-year count, planned starts included, not rows of this table: about 19 trials starting in 2026 and about 14 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored. The 2026 forecast is below the 20 already registered with a 2026 start date: at the cutoff, 4 trials were already registered to start in October to December, more than the method's monthly average allows for, and the method does not use those planned starts.

Prediction, not a registry value: median of 36 months from start to primary completion across 13 trials still running at the 2026-10-09 snapshot; registered median of 32 months across 84 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Adrenogenital Syndrome trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 12
Phase 1/2 6
Phase 2 31
Phase 2/3 2
Phase 3 11
Phase 4 12
Not applicable 33
Observational 69

How many Adrenogenital Syndrome trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 11
Recruiting 28
Enrolling by invitation 2
Active, not recruiting 5
Completed 77

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Adrenogenital Syndrome trials? (6)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Neurocrine UK Limited 8
Neurocrine Biosciences 6
Spruce Biosciences 5
Crinetics Pharmaceuticals Inc. 4
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 4

Which drugs are being tested for Adrenogenital Syndrome? (5)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Crinecerfont 6
Atumelnant 4
SPR001 3
.spironolactone 3
Osilodrostat 3

Interventions as named in the registry (10)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Hydrocortisone 1% 13
1% Metformin 10
Chronocort 7
Progesterone 8% 3
Dexamethasone/Dexamethasone acetate 3

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Adrenogenital Syndrome trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Gastroenteritis 8 4
Hospitalisation 8 1
Pyrexia 5 4
Adrenocortical insufficiency acute 4 2
Vomiting 4 3

Which publications cover Adrenogenital Syndrome? (1)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Clitoral sensitivity after surgical correction in women with adrenogenital syndrome: a long term follow-up. Scandinavian journal of plastic and reconstructive surgery and hand surgery 2003 Yes

Rare-disease identity (2)

Shown in this order: exact, broader, narrower, other.

Rare-disease identity
Orphanet disease ORPHA code Relation Source
Adrenogenital syndrome 181412 Exact Orphanet Rare Disease Ontology (ORDO)
Adrenogenital syndrome 181412 Exact Orphadata Science knowledge files, Product 1

Sub-conditions in MeSH (2)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence.

Browse all condition evidence pages