Condition (MeSH)
Fractures, Bone
ClinicalTrials.gov lists 3,429 trials for Fractures, Bone or a narrower condition beneath it. Zimmer Biomet has the most among industry and government lead sponsors, with 56.
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Trials per phase (log scale)
2 more sections with rows
716 of the 3,429 trials are tagged with Fractures, Bone itself; the rest are tagged with a narrower condition beneath it.
When did Fractures, Bone trials start? (37)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 6 trials are registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
- Other (Expanded access, Unknown)
Top of scale: 258
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 168 |
| 2025 | 195 |
| 2024 | 258 |
| 2023 | 228 |
| 2022 | 226 |
| 2021 | 236 |
| 2020 | 199 |
| 2019 | 205 |
| 2018 | 188 |
| 2017 | 166 |
Showing 10 of 37 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 200 trials starting in 2026 and about 210 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 13 percent and ran about 12 percent low against the count later registered; forecasts made before the year began were off by about 19 percent and ran about 17 percent low against the count later registered, and had about the same error as repeating last year's count. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 275 trials still running at the 2026-10-09 snapshot; registered median of 24 months across 1,974 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Fractures, Bone trials in? (10)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 59 |
| Phase 1/2 | 30 |
| Phase 2 | 103 |
| Phase 2/3 | 28 |
| Phase 3 | 123 |
| Phase 4 | 262 |
| Not applicable | 1,758 |
| Observational | 1,064 |
| Expanded access | 1 |
| Unknown | 1 |
How many Fractures, Bone trials are recruiting? (10)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 161 |
| Recruiting | 351 |
| Enrolling by invitation | 39 |
| Active, not recruiting | 139 |
| Completed | 1,692 |
Showing 5 of 10 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Fractures, Bone trials? (1)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Zimmer Biomet | 56 |
Which drugs are being tested for Fractures, Bone? (3)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| +/- Bupivacaine HCl | 41 |
| DEXMEDETOMIDINE | 20 |
| PMI-150 (intranasal ketamine) | 17 |
Interventions as named in the registry (12)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Ropivacaine 2 % | 32 |
| acid tranexamic | 29 |
| Transdermal Teriparatide | 20 |
| PO Morphine | 18 |
| Pericapsular Nerve Group (PENG) Block | 18 |
Showing 5 of 12 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Fractures, Bone trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Study Fracture Related Complication | 1,462 | 2 |
| Other | 1,304 | 5 |
| Pneumonia | 518 | 29 |
| Other serious adverse event | 378 | 1 |
| Anaemia | 337 | 12 |
Showing 5 of 10 adverse events.
Which publications cover Fractures, Bone? (1,992)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Avascular Necrosis and Minimal Trauma Fractures in Telomere Biology Disorders. | Clinical genetics | 2026 | Yes |
| Incidence, characteristics, and consequences of fractures after acute ischemic stroke and TIA-A prospective cohort study. | International journal of stroke : official journal of the International Stroke Society | 2025 | Yes |
| Closed Reduction Percutaneous Pinning Versus Open Reduction With Plate and Screw Fixation in Management of Unstable Proximal Phalangeal Fractures: A Systematic Review and Meta-analysis. | Hand (New York, N.Y.) | 2025 | Yes |
| Ultrasound in bone fracture diagnosis - a comparative meta-analysis and systematic review. | Medical ultrasonography | 2025 | Yes |
| Combining Innovative Techniques: Total Extraperitoneal Approach in Orthopedic Surgery (O-TEP) and Percutaneous Both Column Screw (BCS) Fixation Technique in a Geriatric Acetabular Fracture Case. | Zeitschrift fur Orthopadie und Unfallchirurgie | 2025 | Yes |
Showing 5 of 1,992 publications.
Sub-conditions in MeSH (28)
MeSH descendants one level down with at least one trial, most trials first.
+18 more sub-conditions
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.