Condition (MeSH)
Headache Disorders, Secondary
ClinicalTrials.gov lists 355 trials for Headache Disorders, Secondary or a narrower condition beneath it. Zagazig University has the most among industry and government lead sponsors, with 5.
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Trials per phase (log scale)
51 of the 355 trials are tagged with Headache Disorders, Secondary itself; the rest are tagged with a narrower condition beneath it.
When did Headache Disorders, Secondary trials start? (25)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 47
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 33 |
| 2025 | 42 |
| 2024 | 30 |
| 2023 | 29 |
| 2022 | 47 |
| 2021 | 21 |
| 2020 | 21 |
| 2019 | 24 |
| 2018 | 18 |
| 2017 | 12 |
Showing 10 of 25 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 43 trials starting in 2026 and about 41 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 35 months from start to primary completion across 32 trials still running at the 2026-10-09 snapshot; registered median of 14 months across 216 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Headache Disorders, Secondary trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 11 |
| Phase 1/2 | 7 |
| Phase 2 | 20 |
| Phase 2/3 | 3 |
| Phase 3 | 15 |
| Phase 4 | 28 |
| Not applicable | 199 |
| Observational | 72 |
How many Headache Disorders, Secondary trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 23 |
| Recruiting | 45 |
| Enrolling by invitation | 4 |
| Active, not recruiting | 10 |
| Completed | 188 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Headache Disorders, Secondary trials? (1)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Zagazig University | 5 |
Which drugs are being tested for Headache Disorders, Secondary? (2)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Eptinezumab | 4 |
| Pregabalin | 3 |
Interventions as named in the registry (13)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Sphenopalatine Ganglion Block | 10 |
| Conventional Therapy | 5 |
| Sumatriptan 5% | 5 |
| Erenumab PFS | 4 |
| Dexamethasone/Dexamethasone acetate | 4 |
Showing 5 of 13 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Headache Disorders, Secondary trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Appendicitis | 3 | 2 |
| COVID-19 pneumonia | 3 | 1 |
| Migraine | 3 | 2 |
| Cholelithiasis | 2 | 2 |
| Planned surgical procedure | 2 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Headache Disorders, Secondary? (93)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Efficacy and Safety of Erenumab in Adults With Medication Overuse Headache: Final Results From a Phase 4 Randomized Placebo-Controlled Study. | European journal of neurology | 2025 | Yes |
| Medication-overuse headache: a narrative review. | The journal of headache and pain | 2024 | Yes |
| Involvement of Plasma Melatonin in Medication-Overuse Headache: A Cross-Sectional Study. | Clinical neuropharmacology | 2024 | Yes |
| Efficacy of mindfulness added to treatment as usual in patients with chronic migraine and medication overuse headache: a phase-III single-blind randomized-controlled trial (the MIND-CM study). | The journal of headache and pain | 2023 | Yes |
| Medication overuse headache. | Nature reviews. Disease primers | 2023 | Yes |
Showing 5 of 93 publications.
Sub-conditions in MeSH (3)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.