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Condition (MeSH)

Brugada Syndrome

ClinicalTrials.gov lists 51 trials for Brugada Syndrome or a narrower condition beneath it. Abbott Medical Devices has the most among industry and government lead sponsors, with 1.

MeSH D053840 Cardiovascular Diseases C14 C16 Listed by Orphanet as a rare disease
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Phase 2 Phase 2 2 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 2 Phase 4 Phase 4 1 Not applicable Not applicable 13 Observational Observational 32 Phase 2 Phase 2 2 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 2 Phase 4 Phase 4 1 Not applicable Not applicable 13 Observational Observational 32

Trials per phase (log scale)

51 of the 51 trials are tagged with Brugada Syndrome itself; the rest are tagged with a narrower condition beneath it.

Get the Brugada Syndrome report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Brugada Syndrome trials start? (20)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 8

1992: 1 trials (Observational 1) 2003: 1 trials (Observational 1) 2004: 1 trials (Observational 1) 2008: 2 trials (Phase 4 1, Phase 3 1) 2009: 2 trials (Phase 3 1, Phase 2/3 1) 2010: 1 trials (Observational 1) 2011: 2 trials (Observational 1, Not applicable 1) 2013: 1 trials (Observational 1) 2014: 1 trials (Observational 1) 2015: 5 trials (Observational 2, Not applicable 3) 2016: 2 trials (Observational 1, Not applicable 1) 2017: 7 trials (Observational 5, Not applicable 1, Phase 2 1) 2018: 8 trials (Observational 7, Not applicable 1) 2020: 3 trials (Observational 2, Not applicable 1) 2021: 5 trials (Observational 2, Not applicable 3) 2022: 1 trials (Observational 1) 2023: 1 trials (Not applicable 1) 2024: 2 trials (Observational 2) 2025: 3 trials (Observational 2, Phase 2 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 2
2025 3
2024 2
2023 1
2022 1
2021 5
2020 3
2018 8
2017 7
2016 2

No forecast is made for this condition: it averages 1.8 trial starts a year over the five years to September, under the 5 a year the method needs.

Recruitment duration, a model prediction: 2 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Brugada Syndrome trials in? (6)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 2 2
Phase 2/3 1
Phase 3 2
Phase 4 1
Not applicable 13
Observational 32

How many Brugada Syndrome trials are recruiting? (7)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 3
Recruiting 11
Enrolling by invitation 1
Completed 20
Terminated 2

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Brugada Syndrome trials? (1)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Abbott Medical Devices 1

Which drugs are being tested for Brugada Syndrome? (5)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Ajmaline 4
Flecainide 2
Ajmaline 17-(Chloroacetate) Monohydrochloride 1
Quinidine 1
Procainamide 1

Interventions as named in the registry (7)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
hydroquinidine 1
Empagliflozine 1
Sham Procedure 1
MRI 1
no therapy 1

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Brugada Syndrome trials report? (1)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
no adverse events recorded† 0 1

Which publications cover Brugada Syndrome? (68)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Eighteen-year analysis of anaesthetic management in Brugada syndrome: The BRUGANAES study. European journal of anaesthesiology 2025 Yes
Subcutaneous Implantable Defibrillator Therapy in Patients With Brugada Syndrome: Data From a Large Multicenter Registry. JACC. Clinical electrophysiology 2025 Yes
Epicardial ablation in high-risk Brugada syndrome to prevent ventricular fibrillation: results from a randomized clinical trial. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2025 Yes
Efficacy and safety of catheter ablation for Brugada syndrome: an updated systematic review. Clinical research in cardiology : official journal of the German Cardiac Society 2023 Yes
Neuraxial anesthesia for delivery in parturtients with Brugada syndrome: Local anesthetics revisited. Journal of gynecology obstetrics and human reproduction 2023 Yes

Prevalence (6)

Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.

Prevalence
Orphanet disease Type Class Geography Jurisdiction Mapping relation
Brugada syndrome Point prevalence 1-5 / 10 000 Europe Not stated Exact
Brugada syndrome Point prevalence 6-9 / 10 000 South East Asia Not stated Unspecified
Brugada syndrome Point prevalence 1-5 / 10 000 Europe Not stated Unspecified
Brugada syndrome Point prevalence 6-9 / 10 000 South East Asia Not stated Exact
Brugada syndrome Point prevalence 6-9 / 10 000 South East Asia Not stated Exact

Rare-disease identity (2)

Shown in this order: exact, broader, narrower, other.

Rare-disease identity
Orphanet disease ORPHA code Relation Source
Brugada syndrome 130 Exact Orphadata Science knowledge files, Product 1
Brugada syndrome 130 Exact Orphanet Rare Disease Ontology (ORDO)

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: sub-conditions in mesh.

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