Condition (MeSH)
Immune Reconstitution Inflammatory Syndrome
ClinicalTrials.gov lists 14 trials for Immune Reconstitution Inflammatory Syndrome or a narrower condition beneath it. National Institute of Allergy and Infectious Diseases (NIAID) has the most among industry and government lead sponsors, with 3.
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Trials per phase
14 of the 14 trials are tagged with Immune Reconstitution Inflammatory Syndrome itself; the rest are tagged with a narrower condition beneath it.
When did Immune Reconstitution Inflammatory Syndrome trials start? (10)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 3
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2022 | 1 |
| 2019 | 1 |
| 2015 | 1 |
| 2014 | 2 |
| 2013 | 3 |
| 2012 | 2 |
| 2010 | 1 |
| 2009 | 1 |
| 2008 | 1 |
| 2006 | 1 |
No forecast is made for this condition: it averages 0.2 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: none of the 14 trials evaluated at the 2026-10-09 snapshot is predicted and still running. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Immune Reconstitution Inflammatory Syndrome trials in? (6)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 2 | 1 |
| Phase 2/3 | 1 |
| Phase 3 | 1 |
| Phase 4 | 1 |
| Not applicable | 4 |
| Observational | 6 |
How many Immune Reconstitution Inflammatory Syndrome trials are recruiting? (5)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Recruiting | 3 |
| Completed | 8 |
| Terminated | 1 |
| Withdrawn | 1 |
| Unknown status | 1 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Immune Reconstitution Inflammatory Syndrome trials? (5)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| National Institute of Allergy and Infectious Diseases (NIAID) | 3 |
| Biogen | 1 |
| Fondation Ophtalmologique Adolphe de Rothschild | 1 |
| National Institute of Cancerología | 1 |
| National Institute of Neurological Disorders and Stroke (NINDS) | 1 |
Which drugs are being tested for Immune Reconstitution Inflammatory Syndrome? (5)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| PREDNISOLONE | 1 |
| ATORVASTATIN | 1 |
| Maraviroc | 1 |
| Prednisone | 1 |
| METHYLPREDNISOLONE | 1 |
Interventions as named in the registry (4)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Valganciclovir | 1 |
| Dexamethasone/Dexamethasone acetate | 1 |
| 1: Naproxen | 1 |
| Antiretroviral Combinations | 1 |
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Immune Reconstitution Inflammatory Syndrome trials report? (7)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Mortality | 39 | 1 |
| Non-mortality SAE | 35 | 1 |
| Progressive Multifocal Leukoencephalopathy | 2 | 1 |
| Grand Mal Convulsion | 1 | 1 |
| Immune Reconstitution Syndrome | 1 | 1 |
Showing 5 of 7 adverse events.
Which publications cover Immune Reconstitution Inflammatory Syndrome? (56)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
Showing 5 of 56 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.