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Condition (MeSH)

Ventilator-Induced Lung Injury

ClinicalTrials.gov lists 470 trials for Ventilator-Induced Lung Injury or a narrower condition beneath it. NICHD Neonatal Research Network has the most among industry and government lead sponsors, with 14.

MeSH D055397 Respiratory Tract Diseases C08
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Phase 1 Phase 1 26 Phase 1/2 Phase 1/2 17 Phase 2 Phase 2 40 Phase 2/3 Phase 2/3 11 Phase 3 Phase 3 37 Phase 4 Phase 4 18 Not applicable Not applicable 173 Observational Observational 148 Phase 1 Phase 1 26 Phase 1/2 Phase 1/2 17 Phase 2 Phase 2 40 Phase 2/3 Phase 2/3 11 Phase 3 Phase 3 37 Phase 4 Phase 4 18 Not applicable Not applicable 173 Observational Observational 148

Trials per phase

119 of the 470 trials are tagged with Ventilator-Induced Lung Injury itself; the rest are tagged with a narrower condition beneath it.

Get the Ventilator-Induced Lung Injury report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Ventilator-Induced Lung Injury trials start? (33)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 36

1991: 2 trials (Not applicable 1, Phase 2/3 1) 1992: 1 trials (Phase 3 1) 1993: 2 trials (Observational 1, Phase 3 1) 1995: 1 trials (Phase 3 1) 1996: 4 trials (Observational 1, Phase 3 1, Phase 2 1, Phase 1/2 1) 1998: 1 trials (Phase 3 1) 2000: 3 trials (Phase 3 2, Phase 1/2 1) 2001: 3 trials (Not applicable 2, Phase 3 1) 2002: 3 trials (Observational 2, Phase 1/2 1) 2003: 1 trials (Phase 1 1) 2004: 4 trials (Observational 1, Not applicable 1, Phase 3 1, Phase 2 1) 2005: 6 trials (Observational 1, Not applicable 1, Phase 3 2, Phase 2 2) 2006: 6 trials (Observational 2, Phase 3 1, Phase 2/3 1, Phase 2 2) 2007: 12 trials (Observational 3, Not applicable 5, Phase 3 1, Phase 2 1, Phase 1/2 1, Phase 1 1) 2008: 7 trials (Not applicable 2, Phase 3 2, Phase 2/3 1, Phase 2 1, Phase 1 1) 2009: 8 trials (Observational 1, Not applicable 1, Phase 4 3, Phase 3 2, Phase 2/3 1) 2010: 11 trials (Observational 2, Phase 4 1, Phase 3 2, Phase 2 3, Phase 1 3) 2011: 15 trials (Observational 5, Not applicable 4, Phase 4 1, Phase 3 2, Phase 2/3 1, Phase 2 2) 2012: 12 trials (Observational 5, Not applicable 3, Phase 4 1, Phase 3 1, Phase 2/3 2) 2013: 13 trials (Observational 5, Not applicable 3, Phase 4 1, Phase 2/3 1, Phase 2 3) 2014: 15 trials (Observational 2, Not applicable 11, Phase 2 1, Phase 1 1) 2015: 14 trials (Observational 1, Not applicable 9, Phase 3 2, Phase 2 1, Phase 1/2 1) 2016: 15 trials (Observational 5, Not applicable 6, Phase 3 2, Phase 1/2 2) 2017: 24 trials (Observational 5, Not applicable 13, Phase 4 1, Phase 2/3 1, Phase 2 2, Phase 1 2) 2018: 35 trials (Observational 10, Not applicable 15, Phase 4 1, Phase 2 5, Phase 1 4) 2019: 35 trials (Observational 12, Not applicable 7, Phase 4 3, Phase 3 1, Phase 2 4, Phase 1/2 4, Phase 1 4) 2020: 36 trials (Observational 21, Not applicable 14, Phase 3 1) 2021: 29 trials (Observational 8, Not applicable 13, Phase 4 1, Phase 3 4, Phase 2 2, Phase 1 1) 2022: 26 trials (Observational 8, Not applicable 12, Phase 4 1, Phase 3 2, Phase 1/2 1, Phase 1 2) 2023: 27 trials (Observational 12, Not applicable 12, Phase 4 1, Phase 2/3 1, Phase 1/2 1) 2024: 35 trials (Observational 13, Not applicable 14, Phase 4 2, Phase 3 1, Phase 2 2, Phase 1/2 2, Phase 1 1) 2025: 22 trials (Observational 6, Not applicable 8, Phase 4 1, Phase 2/3 1, Phase 2 3, Phase 1 3)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 35
2025 22
2024 35
2023 27
2022 26
2021 29
2020 36
2019 35
2018 35
2017 24

Showing 10 of 33 earlier years.

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Forecast of the full-year count, planned starts included, not rows of this table: about 41 trials starting in 2026 and about 31 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 55 trials still running at the 2026-10-09 snapshot; registered median of 24 months across 251 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Ventilator-Induced Lung Injury trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 26
Phase 1/2 17
Phase 2 40
Phase 2/3 11
Phase 3 37
Phase 4 18
Not applicable 173
Observational 148

How many Ventilator-Induced Lung Injury trials are recruiting? (8)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 32
Recruiting 63
Enrolling by invitation 4
Active, not recruiting 16
Completed 222

Showing 5 of 8 statuses.

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Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Ventilator-Induced Lung Injury trials? (3)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
NICHD Neonatal Research Network 14
Medipost Co Ltd. 6
National Heart, Lung, and Blood Institute (NHLBI) 5

Which drugs are being tested for Ventilator-Induced Lung Injury? (2)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
L-Citrulline 3
Calfactant 3

Interventions as named in the registry (13)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
PNEUMOSTEM 6
citrate of caffeine 6
1% Azithromycin 6
Budesonide EC 6
Inhaled Nitric Oxide (iNO) use 5

Showing 5 of 13 interventions.

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These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Ventilator-Induced Lung Injury trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Patent Ductus Aretriosus 631 1
Death 295 3
Respiratory Deterioration up to 24 hours post-transfusion 178 1
Necrotizing enterocolitis 167 3
Intraventricular hemorrhage (IVH) Grade 3 or 4 164 1

Showing 5 of 10 adverse events.

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Which publications cover Ventilator-Induced Lung Injury? (168)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Spontaneous breathing-induced lung injury in mechanically ventilated patients. Current opinion in critical care 2025 Yes
Evaluation of health care providers' ability to identify patient-ventilator triggering asynchrony in intensive care unit: a translational observational study in China. BMC medical education 2025 Yes
Electrical impedance tomography-guided positive end-expiratory pressure titration in ARDS: a systematic review and meta-analysis. Intensive care medicine 2024 Yes
Comparison of limited driving pressure ventilation and low tidal volume strategies in adults with acute respiratory failure on mechanical ventilation: a randomized controlled trial. Therapeutic advances in respiratory disease 2024 Yes
Sigh Ventilation in Patients With Trauma: The SiVent Randomized Clinical Trial. JAMA 2023 Yes

Showing 5 of 168 publications.

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Sub-conditions in MeSH (1)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

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