Condition (MeSH)
Costello Syndrome
ClinicalTrials.gov lists 8 trials for Costello Syndrome or a narrower condition beneath it. National Cancer Institute (NCI) has the most among industry and government lead sponsors, with 3.
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Trials per phase
8 of the 8 trials are tagged with Costello Syndrome itself; the rest are tagged with a narrower condition beneath it.
When did Costello Syndrome trials start? (6)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Not applicable
- Observational
Top of scale: 3
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 1 |
| 2024 | 1 |
| 2022 | 1 |
| 2021 | 3 |
| 2017 | 1 |
| 2015 | 1 |
No forecast is made for this condition: it averages 0.6 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 1 trial still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Costello Syndrome trials in? (2)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Not applicable | 5 |
| Observational | 3 |
How many Costello Syndrome trials are recruiting? (4)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 1 |
| Recruiting | 4 |
| Terminated | 1 |
| Unknown status | 2 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Costello Syndrome trials? (1)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| National Cancer Institute (NCI) | 3 |
Which publications cover Costello Syndrome? (5)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Malignancy in Noonan syndrome and related disorders. | Clinical genetics | 2015 | Yes |
| Cancer spectrum and frequency among children with Noonan, Costello, and cardio-facio-cutaneous syndromes. | British journal of cancer | 2015 | Yes |
| Perinatal features of the RASopathies: Noonan syndrome, cardiofaciocutaneous syndrome and Costello syndrome. | American journal of medical genetics. Part A | 2014 | Yes |
| RASopathies Are Associated With Delayed Puberty; Are They Associated With Precocious Puberty Too? | Pediatrics | 2016 | No |
| Behavioral profile in RASopathies. | American journal of medical genetics. Part A | 2014 | No |
Prevalence (9)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Costello syndrome | Point prevalence | <1 / 1 000 000 | Japan | Not stated | Unspecified |
| Costello syndrome | Point prevalence | <1 / 1 000 000 | Japan | Not stated | Exact |
| Costello syndrome | Cases families | Worldwide | Not stated | Unspecified | |
| Costello syndrome | Cases families | Worldwide | Not stated | Exact | |
| Costello syndrome | Point prevalence | <1 / 1 000 000 | Japan | Not stated | Exact |
Showing 5 of 9 prevalence observations.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Costello syndrome | 3071 | Exact | Orphanet Rare Disease Ontology (ORDO) |
| Costello syndrome | 3071 | Exact | Orphadata Science knowledge files, Product 1 |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: serious adverse events in this condition's trials and sub-conditions in mesh.
Not computed for conditions with fewer than 10 trials: drugs tested.