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Condition (MeSH)

Acute Kidney Injury

ClinicalTrials.gov lists 1,612 trials for Acute Kidney Injury or a narrower condition beneath it.

MeSH D058186 Urogenital Diseases C12
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Phase 1 Phase 1 37 Phase 1/2 Phase 1/2 15 Phase 2 Phase 2 110 Phase 2/3 Phase 2/3 30 Phase 3 Phase 3 72 Phase 4 Phase 4 107 Not applicable Not applicable 446 Observational Observational 795 Phase 1 Phase 1 37 Phase 1/2 Phase 1/2 15 Phase 2 Phase 2 110 Phase 2/3 Phase 2/3 30 Phase 3 Phase 3 72 Phase 4 Phase 4 107 Not applicable Not applicable 446 Observational Observational 795

Trials per phase (log scale)

1,609 of the 1,612 trials are tagged with Acute Kidney Injury itself; the rest are tagged with a narrower condition beneath it.

Get the Acute Kidney Injury report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Acute Kidney Injury trials start? (30)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 4 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 139

1996: 1 trials (Not applicable 1) 1998: 1 trials (Not applicable 1) 1999: 1 trials (Phase 1 1) 2000: 1 trials (Observational 1) 2001: 1 trials (Observational 1) 2002: 4 trials (Phase 4 1, Phase 2/3 1, Phase 2 2) 2003: 11 trials (Observational 3, Not applicable 1, Phase 4 2, Phase 3 3, Phase 2 1, Phase 1/2 1) 2004: 7 trials (Not applicable 3, Phase 4 2, Phase 2 2) 2005: 15 trials (Observational 4, Not applicable 5, Phase 4 4, Phase 3 1, Phase 2/3 1) 2006: 19 trials (Observational 6, Not applicable 2, Phase 4 1, Phase 3 5, Phase 2/3 1, Phase 2 3, Phase 1/2 1) 2007: 16 trials (Observational 8, Not applicable 2, Phase 4 3, Phase 2/3 1, Phase 2 1, Phase 1 1) 2008: 32 trials (Observational 11, Not applicable 6, Phase 4 2, Phase 3 4, Phase 2/3 3, Phase 2 2, Phase 1 4) 2009: 31 trials (Observational 10, Not applicable 5, Phase 4 4, Phase 3 3, Phase 2/3 2, Phase 2 5, Phase 1/2 1, Phase 1 1) 2010: 40 trials (Observational 15, Not applicable 13, Phase 4 3, Phase 3 3, Phase 2 4, Phase 1 2) 2011: 33 trials (Observational 13, Not applicable 11, Phase 4 4, Phase 2/3 2, Phase 2 3) 2012: 40 trials (Observational 18, Not applicable 12, Phase 4 3, Phase 3 4, Phase 2 3) 2013: 69 trials (Observational 35, Not applicable 19, Phase 4 6, Phase 3 1, Phase 2 5, Phase 1 3) 2014: 57 trials (Observational 32, Not applicable 15, Phase 4 2, Phase 3 1, Phase 2 4, Phase 1 3) 2015: 80 trials (Observational 37, Not applicable 23, Phase 4 9, Phase 3 2, Phase 2/3 1, Phase 2 3, Phase 1/2 3, Phase 1 2) 2016: 79 trials (Observational 39, Not applicable 22, Phase 4 6, Phase 3 5, Phase 2/3 2, Phase 2 3, Phase 1 2) 2017: 83 trials (Observational 39, Not applicable 27, Phase 4 3, Phase 3 5, Phase 2/3 1, Phase 2 5, Phase 1/2 1, Phase 1 2) 2018: 88 trials (Observational 47, Not applicable 25, Phase 4 6, Phase 3 3, Phase 2 4, Phase 1 3) 2019: 89 trials (Observational 48, Not applicable 25, Phase 4 4, Phase 3 8, Phase 2/3 2, Phase 2 2) 2020: 116 trials (Observational 67, Not applicable 30, Phase 4 7, Phase 3 4, Phase 2 7, Phase 1/2 1) 2021: 102 trials (Observational 57, Not applicable 25, Phase 4 3, Phase 3 3, Phase 2/3 2, Phase 2 8, Phase 1/2 1, Phase 1 3) 2022: 105 trials (Observational 60, Not applicable 28, Phase 4 5, Phase 3 3, Phase 2/3 1, Phase 2 7, Phase 1 1) 2023: 118 trials (Observational 56, Not applicable 36, Phase 4 4, Phase 3 8, Phase 2/3 3, Phase 2 7, Phase 1/2 3, Phase 1 1) 2024: 139 trials (Observational 78, Not applicable 38, Phase 4 9, Phase 3 2, Phase 2/3 3, Phase 2 6, Phase 1 3) 2025: 101 trials (Observational 41, Not applicable 35, Phase 4 4, Phase 3 3, Phase 2/3 3, Phase 2 12, Phase 1 3)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 125
2025 101
2024 139
2023 118
2022 105
2021 102
2020 116
2019 89
2018 88
2017 83

Forecast of the full-year count, planned starts included, not rows of this table: about 140 trials starting in 2026 and about 120 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 13 percent and ran about 12 percent low against the count later registered; forecasts made before the year began were off by about 19 percent and ran about 17 percent low against the count later registered, and had about the same error as repeating last year's count. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 116 trials still running at the 2026-10-09 snapshot; registered median of 21 months across 933 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Acute Kidney Injury trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 37
Phase 1/2 15
Phase 2 110
Phase 2/3 30
Phase 3 72
Phase 4 107
Not applicable 446
Observational 795

How many Acute Kidney Injury trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 114
Recruiting 182
Enrolling by invitation 11
Active, not recruiting 42
Completed 810

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which drugs are being tested for Acute Kidney Injury? (8)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
DEXMEDETOMIDINE 13
PROPOFOL 11
Angiotensin II 9
BMS-512148 8
Aminophylline 6

Interventions as named in the registry (7)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
sodium bicarbonate 8.4% 15
Furosemide-IR 11
continuous renal replacement therapy 11
NaCl 0.9% NS 10
Terlipressinum 10

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Acute Kidney Injury trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Acute Kidney Injury Stage I or greater 1,912 1
Coronary artery disease 738 4
Mortality 711 2
Myocardial Infarction 528 1
New Heart Failure 459 1

Which publications cover Acute Kidney Injury? (2,498)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Sub-conditions in MeSH (1)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: lead sponsors, prevalence, and rare-disease identity.

Browse all condition evidence pages