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Condition (MeSH)

Mastodynia

ClinicalTrials.gov lists 43 trials for Mastodynia or a narrower condition beneath it.

MeSH D059373 Pathological Conditions, Signs and Symptoms C23
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Phase 1 Phase 1 1 Phase 2 Phase 2 2 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 5 Phase 4 Phase 4 8 Not applicable Not applicable 21 Observational Observational 5 Phase 1 Phase 1 1 Phase 2 Phase 2 2 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 5 Phase 4 Phase 4 8 Not applicable Not applicable 21 Observational Observational 5

Trials per phase (log scale)

43 of the 43 trials are tagged with Mastodynia itself; the rest are tagged with a narrower condition beneath it.

Get the Mastodynia report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Mastodynia trials start? (21)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 5

2003: 3 trials (Not applicable 1, Phase 4 1, Phase 2 1) 2005: 2 trials (Phase 3 1, Phase 2/3 1) 2006: 1 trials (Phase 4 1) 2007: 2 trials (Phase 3 1, Phase 2 1) 2008: 1 trials (Phase 4 1) 2010: 1 trials (Phase 4 1) 2011: 1 trials (Not applicable 1) 2012: 1 trials (Not applicable 1) 2013: 1 trials (Phase 3 1) 2015: 1 trials (Not applicable 1) 2016: 2 trials (Observational 1, Phase 4 1) 2017: 2 trials (Not applicable 2) 2018: 5 trials (Not applicable 4, Phase 4 1) 2019: 4 trials (Not applicable 3, Phase 4 1) 2020: 2 trials (Not applicable 2) 2021: 3 trials (Observational 2, Phase 4 1) 2022: 3 trials (Observational 1, Not applicable 2) 2023: 1 trials (Not applicable 1) 2024: 1 trials (Not applicable 1) 2025: 4 trials (Observational 1, Not applicable 1, Phase 3 2)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 2
2025 4
2024 1
2023 1
2022 3
2021 3
2020 2
2019 4
2018 5
2017 2

No forecast is made for this condition: it averages 2.2 trial starts a year over the five years to September, under the 5 a year the method needs.

Prediction, not a registry value: median of 31 months from start to primary completion across 6 trials still running at the 2026-10-09 snapshot; registered median of 20 months across 25 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Mastodynia trials in? (7)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 1
Phase 2 2
Phase 2/3 1
Phase 3 5
Phase 4 8
Not applicable 21
Observational 5

How many Mastodynia trials are recruiting? (6)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 3
Recruiting 4
Completed 22
Terminated 3
Withdrawn 1

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Mastodynia trials? (3)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
ASCEND Therapeutics 1
Bionorica SE 1
Biosearch S.A. 1

Interventions as named in the registry (15)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Acupuncture 3
Serratus anterior plane block (SAP) 1
Serratus Posterior Superior Intercostal Plane Block 1
Ropivacaine 2 % 1
IoGen (molecular iodine) 1

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which publications cover Mastodynia? (23)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Auricular Acupressure on Breast Pain Among Breastfeeding Mothers Receiving Gentle Hand Techniques: A Randomized, Single-Blind, Sham-Controlled Trial. Journal of human lactation : official journal of International Lactation Consultant Association 2024 Yes
Effect of cold cabbage leaf application on breast engorgement and pain in the postpartum period: A systematic review and meta-analysis. Health care for women international 2023 Yes
Optimizing Preventive Adjuvant Linac-Based (OPAL) Radiation: A Phase 2 Trial of Daily Partial Breast Irradiation. International journal of radiation oncology, biology, physics 2023 Yes
Effect of Tea Tree Oil and Coconut Oil on Nipple Crack Formation in the Early Postpartum Period. Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine 2023 Yes
Evaluating GPT as an Adjunct for Radiologic Decision Making: GPT-4 Versus GPT-3.5 in a Breast Imaging Pilot. Journal of the American College of Radiology : JACR 2023 Yes

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: serious adverse events in this condition's trials, prevalence, rare-disease identity, and sub-conditions in mesh.

Browse all condition evidence pages