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Clinical trial

Radiotherapy With Concurrent Cetuximab vs. Carboplatin and Paclitaxel in Patients With Stage III-IVB Head and Neck Cancer With a Contraindication to Cisplatin: A Pragmatic Phase III Randomized Trial

NCT07441681 is registered in ClinicalTrials.gov with NRG Oncology as lead sponsor.

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Registry record

As filed in ClinicalTrials.gov.

Title
Radiotherapy With Concurrent Cetuximab vs. Carboplatin and Paclitaxel in Patients With Stage III-IVB Head and Neck Cancer With a Contraindication to Cisplatin: A Pragmatic Phase III Randomized Trial
Lead sponsor
NRG Oncology
Phase
Phase 3
Overall status
Recruiting
Start date
July 31, 2026
Completion date
November 30, 2040
Enrollment
454 (estimated)
Sites
63

Conditions

As the registry lists them; a condition with its own page is linked.

clinical stage i hpv-mediated (p16-positive) oropharyngeal carcinoma ajcc v8, clinical stage ii hpv-mediated (p16-positive) oropharyngeal carcinoma ajcc v8, clinical stage iii hpv-mediated (p16-positive) oropharyngeal carcinoma ajcc v8, head and neck squamous cell carcinoma, stage iii hypopharyngeal carcinoma ajcc v8, stage iii laryngeal cancer ajcc v8, stage iii lip and oral cavity cancer ajcc v8, stage iii oropharyngeal (p16-negative) carcinoma ajcc v8, stage iva hypopharyngeal carcinoma ajcc v8, stage iva laryngeal cancer ajcc v8, stage iva lip and oral cavity cancer ajcc v8, stage iva oropharyngeal (p16-negative) carcinoma ajcc v8, stage ivb hypopharyngeal carcinoma ajcc v8, stage ivb laryngeal cancer ajcc v8, stage ivb lip and oral cavity cancer ajcc v8, stage ivb oropharyngeal (p16-negative) carcinoma ajcc v8