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Clinical trial

A Randomized Phase III Study Comparing Temporally-Modulated Pulsed Radiation Therapy (TMPRT) Versus Standard Radiation Therapy With Temozolomide for Adults With Newly Diagnosed MGMT-Unmethylated Glioblastoma

NCT07452458 is registered in ClinicalTrials.gov with NRG Oncology as lead sponsor.

NCT NCT07452458
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Registry record

As filed in ClinicalTrials.gov.

Title
A Randomized Phase III Study Comparing Temporally-Modulated Pulsed Radiation Therapy (TMPRT) Versus Standard Radiation Therapy With Temozolomide for Adults With Newly Diagnosed MGMT-Unmethylated Glioblastoma
Lead sponsor
NRG Oncology
Phase
Phase 3
Overall status
Recruiting
Start date
July 16, 2026
Completion date
July 15, 2035
Enrollment
398 (estimated)
Sites
54

Conditions

As the registry lists them; a condition with its own page is linked.

glioblastoma, idh-wildtype, mgmt-unmethylated glioblastoma