Condition (MeSH)
Bradycardia
ClinicalTrials.gov lists 297 trials for Bradycardia or a narrower condition beneath it. Medtronic Cardiac Rhythm and Heart Failure has the most among industry and government lead sponsors, with 29.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase (log scale)
297 of the 297 trials are tagged with Bradycardia itself; the rest are tagged with a narrower condition beneath it.
When did Bradycardia trials start? (31)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 21
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 17 |
| 2025 | 17 |
| 2024 | 21 |
| 2023 | 18 |
| 2022 | 21 |
| 2021 | 13 |
| 2020 | 13 |
| 2019 | 10 |
| 2018 | 17 |
| 2017 | 13 |
Showing 10 of 31 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 20 trials starting in 2026 and about 19 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 26 months from start to primary completion across 26 trials still running at the 2026-10-09 snapshot; registered median of 21 months across 170 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Bradycardia trials in? (7)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1/2 | 1 |
| Phase 2 | 4 |
| Phase 2/3 | 5 |
| Phase 3 | 5 |
| Phase 4 | 24 |
| Not applicable | 133 |
| Observational | 125 |
How many Bradycardia trials are recruiting? (9)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 11 |
| Recruiting | 48 |
| Enrolling by invitation | 1 |
| Active, not recruiting | 12 |
| Completed | 167 |
Showing 5 of 9 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Bradycardia trials? (10)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Medtronic Cardiac Rhythm and Heart Failure | 29 |
| Abbott Medical Devices | 26 |
| Boston Scientific Corporation | 15 |
| Medtronic | 9 |
| MicroPort CRM | 9 |
Showing 5 of 10 sponsors.
Which drugs are being tested for Bradycardia? (4)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| DEXMEDETOMIDINE | 5 |
| PROPOFOL | 3 |
| Levobupivacaine | 2 |
| Ephedrine | 2 |
Interventions as named in the registry (11)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Atropine 1% | 9 |
| Control (placebo) group | 3 |
| glycopyrrolate, 2.0% | 3 |
| Ivabradine Pill | 3 |
| Sugamadex | 2 |
Showing 5 of 11 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Bradycardia trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| leading to invasive interventions | 403 | 1 |
| Non-cardiovascular | 357 | 1 |
| Cardiovascular - Non-Heart Failure | 241 | 1 |
| disease progression leading to death | 208 | 1 |
| Premature Battery Depletion | 176 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Bradycardia? (387)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Cardiovascular events observed among patients in the etrasimod clinical programme: an integrated safety analysis of patients with moderately to severely active ulcerative colitis. | BMJ open gastroenterology | 2025 | Yes |
| Bradycardia and Other Arrhythmias in Patients With Hepatorenal Syndrome-Acute Kidney Injury Following Terlipressin Treatment: A Pooled Analysis of Three North American Phase III Clinical Studies. | Alimentary pharmacology & therapeutics | 2025 | Yes |
| One-Year Safety and Performance of a Dual-Chamber Leadless Pacemaker. | Circulation. Arrhythmia and electrophysiology | 2025 | Yes |
| Diagnostic accuracy of an over-the-counter infant pulse oximeter for cardiorespiratory events. | Archives of disease in childhood. Fetal and neonatal edition | 2025 | Yes |
| Atropine Versus Placebo for Neonatal Nonemergent Intubation: A Randomized Clinical Trial. | The Journal of pediatrics | 2025 | Yes |
Showing 5 of 387 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.