Condition (MeSH)
Bundle-Branch Block
ClinicalTrials.gov lists 92 trials for Bundle-Branch Block or a narrower condition beneath it. Boston Scientific Corporation has the most among industry and government lead sponsors, with 3.
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Trials per phase (log scale)
92 of the 92 trials are tagged with Bundle-Branch Block itself; the rest are tagged with a narrower condition beneath it.
When did Bundle-Branch Block trials start? (20)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 2
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 10
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 3 |
| 2025 | 6 |
| 2024 | 6 |
| 2023 | 10 |
| 2022 | 10 |
| 2021 | 3 |
| 2020 | 4 |
| 2019 | 5 |
| 2018 | 9 |
| 2017 | 7 |
Showing 10 of 20 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 3 trials starting in 2026 and about 5 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 10 trials still running at the 2026-10-09 snapshot; registered median of 38 months across 49 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Bundle-Branch Block trials in? (5)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 2 | 1 |
| Phase 3 | 1 |
| Phase 4 | 5 |
| Not applicable | 51 |
| Observational | 34 |
How many Bundle-Branch Block trials are recruiting? (7)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 4 |
| Recruiting | 19 |
| Active, not recruiting | 5 |
| Completed | 31 |
| Terminated | 13 |
Showing 5 of 7 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Bundle-Branch Block trials? (4)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Boston Scientific Corporation | 3 |
| Abbott Medical Devices | 2 |
| Institut für Pharmakologie und Präventive Medizin | 2 |
| Medtronic Cardiac Rhythm and Heart Failure | 2 |
Which drugs are being tested for Bundle-Branch Block? (1)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| METHYLPREDNISOLONE | 2 |
Interventions as named in the registry (10)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Guideline Directed Medical Therapy | 1 |
| low clonidine concentration | 1 |
| Positron Emission Tomography (PET) | 1 |
| Beta Blocker | 1 |
| RAAS blockers | 1 |
Showing 5 of 10 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Bundle-Branch Block trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Not Implanted System or Procedure Related - Cardiac Disorders | 17 | 1 |
| Cardiac failure | 14 | 1 |
| Not Implanted System or Procedure Related - Respiratory, Thoracic, and Mediastinal Disorders | 11 | 1 |
| Not Implanted System or Procedure Related - Surgical and Medical Procedures | 10 | 1 |
| Not Implanted System or Procedure Related - General Disorders | 8 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Bundle-Branch Block? (297)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Influence of Right and Left Bundle Branch Block in Patients With Cardiogenic Shock and Cardiac Arrest. | Critical care medicine | 2025 | Yes |
| Electrophysiological characteristics of lead position-dependent electrogram uninterrupted transition during left bundle branch pacing. | Heart rhythm | 2025 | Yes |
| Mechanism and Impact of Left Atrial Dyssynchrony on Long-Term Clinical Outcome During Cardiac Resynchronization Therapy. | JACC. Cardiovascular imaging | 2025 | Yes |
| Intraprocedural transthoracic EChocardiography to facilitate Left Bundle Branch Pacing: EC-LBBP. | Heart rhythm | 2025 | Yes |
| Performance of an active fixation stylet-driven lead in left bundle branch area pacing: Results from INSIGHT-LBBA. | Heart rhythm | 2025 | Yes |
Showing 5 of 297 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.