Condition (MeSH)
Coloboma
ClinicalTrials.gov lists 16 trials for Coloboma or a narrower condition beneath it. National Eye Institute (NEI) has the most among industry and government lead sponsors, with 4.
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Trials per phase
7 of the 16 trials are tagged with Coloboma itself; the rest are tagged with a narrower condition beneath it.
When did Coloboma trials start? (12)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 4
- Not applicable
- Observational
Top of scale: 2
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 1 |
| 2025 | 2 |
| 2024 | 1 |
| 2023 | 1 |
| 2022 | 1 |
| 2021 | 2 |
| 2018 | 2 |
| 2013 | 2 |
| 2012 | 1 |
| 2006 | 1 |
Showing 10 of 12 earlier years.
No forecast is made for this condition: it averages 1.4 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 1 trial still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Coloboma trials in? (3)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 4 | 1 |
| Not applicable | 2 |
| Observational | 13 |
How many Coloboma trials are recruiting? (5)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Recruiting | 5 |
| Enrolling by invitation | 1 |
| Completed | 7 |
| Terminated | 2 |
| Unknown status | 1 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Coloboma trials? (4)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| National Eye Institute (NEI) | 4 |
| National Human Genome Research Institute (NHGRI) | 1 |
| Pfizer | 1 |
| Zimmer Biomet | 1 |
Interventions as named in the registry (5)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Pimecrolimus Cream 1% | 1 |
| Crisaborole Vehicle | 1 |
| Crisaborole ointment 2% | 1 |
| Hydrocortisone butyrate cream, 0.1% | 1 |
| Blood Sampling | 1 |
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which publications cover Coloboma? (12)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Review of evidence for environmental causes of uveal coloboma. | Survey of ophthalmology | 2022 | Yes |
| Discovery of a novel CHD7 CHARGE syndrome variant by integrated omics analyses. | American journal of medical genetics. Part A | 2021 | Yes |
| De Novo Variants in WDR37 Are Associated with Epilepsy, Colobomas, Dysmorphism, Developmental Delay, Intellectual Disability, and Cerebellar Hypoplasia. | American journal of human genetics | 2019 | Yes |
| Evaluation of the safety of sclerotomy incision in patients with choroidal colobomas with/without associated microcornea. | Retina (Philadelphia, Pa.) | 2014 | Yes |
| A new locus for congenital cataract, microcornea, microphthalmia, and atypical iris coloboma maps to chromosome 2. | Ophthalmology | 2009 | Yes |
Showing 5 of 12 publications.
Sub-conditions in MeSH (2)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: serious adverse events in this condition's trials, prevalence, and rare-disease identity.