Condition (MeSH)
Mandibulofacial Dysostosis
ClinicalTrials.gov lists 15 trials for Mandibulofacial Dysostosis or a narrower condition beneath it.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase
4 of the 15 trials are tagged with Mandibulofacial Dysostosis itself; the rest are tagged with a narrower condition beneath it.
When did Mandibulofacial Dysostosis trials start? (10)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 2
- Phase 4
- Not applicable
- Observational
Top of scale: 3
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 2 |
| 2021 | 1 |
| 2020 | 1 |
| 2019 | 1 |
| 2018 | 2 |
| 2015 | 3 |
| 2013 | 1 |
| 2012 | 2 |
| 2010 | 1 |
| 2005 | 1 |
No forecast is made for this condition: it averages 0.6 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 2 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Mandibulofacial Dysostosis trials in? (5)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 1 |
| Phase 4 | 1 |
| Not applicable | 7 |
| Observational | 5 |
How many Mandibulofacial Dysostosis trials are recruiting? (4)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Recruiting | 3 |
| Completed | 10 |
| Terminated | 1 |
| Unknown status | 1 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Mandibulofacial Dysostosis trials? (3)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| National Human Genome Research Institute (NHGRI) | 1 |
| Pfizer | 1 |
| Zimmer Biomet | 1 |
Interventions as named in the registry (8)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Pimecrolimus Cream 1% | 1 |
| Cultured ASCs enrichment fat grafting | 1 |
| Bone Marrow Aspirate Concentrate | 1 |
| type A botulinum toxin | 1 |
| Crisaborole Vehicle | 1 |
Showing 5 of 8 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which publications cover Mandibulofacial Dysostosis? (8)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Internal mandibular distraction to relieve airway obstruction in children with severe micrognathia. | International journal of oral and maxillofacial surgery | 2014 | Yes |
| Obstructive sleep apnoea in Treacher Collins syndrome: prevalence, severity and cause. | International journal of oral and maxillofacial surgery | 2012 | Yes |
| Round window stimulation with an implantable hearing aid (Soundbridge) combined with autogenous reconstruction of the auricle - a new approach. | ORL; journal for oto-rhino-laryngology and its related specialties | 2006 | Yes |
| Immediate mandibular distraction in mandibular hypoplasia and upper airway obstruction. | The Journal of craniofacial surgery | 2012 | No |
| Revisiting Mendelian disorders through exome sequencing. | Human genetics | 2011 | No |
Showing 5 of 8 publications.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Mandibulofacial dysostosis | 155899 | Exact | Orphanet Rare Disease Ontology (ORDO) |
| Mandibulofacial dysostosis | 155899 | Exact | Orphadata Science knowledge files, Product 1 |
Sub-conditions in MeSH (1)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: serious adverse events in this condition's trials and prevalence.