Condition (MeSH)
Eye Abnormalities
ClinicalTrials.gov lists 121 trials for Eye Abnormalities or a narrower condition beneath it. National Eye Institute (NEI) has the most among industry and government lead sponsors, with 9.
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Trials per phase (log scale)
28 of the 121 trials are tagged with Eye Abnormalities itself; the rest are tagged with a narrower condition beneath it.
When did Eye Abnormalities trials start? (28)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 15
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 4 |
| 2025 | 3 |
| 2024 | 10 |
| 2023 | 8 |
| 2022 | 7 |
| 2021 | 15 |
| 2020 | 7 |
| 2019 | 11 |
| 2018 | 6 |
| 2017 | 5 |
Showing 10 of 28 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 4 trials starting in 2026 and about 5 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 6 trials still running at the 2026-10-09 snapshot; registered median of 24 months across 61 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Eye Abnormalities trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 6 |
| Phase 1/2 | 5 |
| Phase 2 | 9 |
| Phase 2/3 | 5 |
| Phase 3 | 2 |
| Phase 4 | 4 |
| Not applicable | 40 |
| Observational | 50 |
How many Eye Abnormalities trials are recruiting? (9)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 3 |
| Recruiting | 14 |
| Enrolling by invitation | 2 |
| Active, not recruiting | 4 |
| Completed | 59 |
Showing 5 of 9 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Eye Abnormalities trials? (9)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| National Eye Institute (NEI) | 9 |
| Laboratoires Thea | 6 |
| Clearside Biomedical, Inc. | 3 |
| ProQR Therapeutics | 3 |
| Alcon Research | 2 |
Showing 5 of 9 sponsors.
Which drugs are being tested for Eye Abnormalities? (2)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| sepofarsen | 4 |
| Ataluren | 2 |
Interventions as named in the registry (13)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Sham Procedure | 3 |
| QR-421a | 2 |
| Intravitreal Injection of Ultevursen | 2 |
| travoprost 0.003% | 1 |
| 4 mg CLS-TA | 1 |
Showing 5 of 13 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Eye Abnormalities trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Retinal detachment | 3 | 2 |
| Corneal transplant | 2 | 1 |
| Cystoid macular oedema | 2 | 1 |
| Intraocular pressure increased | 2 | 1 |
| Mental disorder | 2 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Eye Abnormalities? (31)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Association of macular outward scleral height with axial length, macular choroidal thickness and morphologic characteristics of the optic disc in Chinese adults. | Eye (London, England) | 2024 | Yes |
| Correlation between Phenotype and Genotype in CTNNB1 Syndrome: A Systematic Review of the Literature. | International journal of molecular sciences | 2022 | Yes |
| Systematic analysis of physical examination characteristics of 94 individuals with Joubert syndrome: Keys to suspecting the diagnosis. | American journal of medical genetics. Part C, Seminars in medical genetics | 2022 | Yes |
| Expanding the Phenotype of the <i>FAM149B1</i>-Related Ciliopathy and Identification of Three Neurogenetic Disorders in a Single Family. | Genes | 2021 | Yes |
| DYRK1A pathogenic variants in two patients with syndromic intellectual disability and a review of the literature. | Molecular genetics & genomic medicine | 2020 | Yes |
Showing 5 of 31 publications.
Sub-conditions in MeSH (10)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.