Condition (MeSH)
Craniopharyngioma
ClinicalTrials.gov lists 74 trials for Craniopharyngioma or a narrower condition beneath it. National Institutes of Health Clinical Center (CC) has the most among industry and government lead sponsors, with 3.
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Trials per phase
74 of the 74 trials are tagged with Craniopharyngioma itself; the rest are tagged with a narrower condition beneath it.
When did Craniopharyngioma trials start? (28)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 5
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 6 |
| 2025 | 5 |
| 2023 | 4 |
| 2022 | 3 |
| 2021 | 1 |
| 2019 | 5 |
| 2018 | 3 |
| 2017 | 2 |
| 2016 | 2 |
| 2015 | 1 |
Showing 10 of 28 earlier years.
No forecast is made for this condition: it averages 3.4 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 36 months from start to primary completion across 9 trials still running at the 2026-10-09 snapshot; registered median of 46 months across 43 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Craniopharyngioma trials in? (7)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 15 |
| Phase 1/2 | 4 |
| Phase 2 | 18 |
| Phase 3 | 6 |
| Phase 4 | 2 |
| Not applicable | 9 |
| Observational | 20 |
How many Craniopharyngioma trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 5 |
| Recruiting | 12 |
| Enrolling by invitation | 2 |
| Active, not recruiting | 6 |
| Completed | 37 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Craniopharyngioma trials? (2)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| National Institutes of Health Clinical Center (CC) | 3 |
| National Cancer Institute (NCI) | 2 |
Which drugs are being tested for Craniopharyngioma? (1)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Exenatide | 3 |
Interventions as named in the registry (14)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Donepezil HCI (drug) | 2 |
| Positron Emission Tomography (PET) | 2 |
| SOC: Temozolomide | 2 |
| tocilizumab SC | 2 |
| IM Oxytocin | 1 |
Showing 5 of 14 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Craniopharyngioma trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Somnolence/depressed level of consciousness | 10 | 2 |
| Seizure | 6 | 3 |
| Vomiting | 5 | 3 |
| Fatigue | 4 | 2 |
| Fever | 4 | 3 |
Showing 5 of 10 adverse events.
Which publications cover Craniopharyngioma? (54)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Daytime sleepiness and health-related quality of life in patients with childhood-onset craniopharyngioma. | Scientific reports | 2025 | Yes |
| Prolactin serum concentrations in childhood-onset craniopharyngioma patients. | Journal of endocrinological investigation | 2025 | Yes |
| High-precision radiotherapy achieves excellent long-term control and preserves function in pediatric craniopharyngioma-Subset analysis of a randomized trial. | Neuro-oncology | 2025 | Yes |
| Impact of exenatide on weight loss and eating behavior in adults with craniopharyngioma-related obesity: the CRANIOEXE randomized placebo-controlled trial. | European journal of endocrinology | 2024 | Yes |
| Outcome after pediatric craniopharyngioma: the role of age at diagnosis and hypothalamic damage. | European journal of endocrinology | 2023 | Yes |
Showing 5 of 54 publications.
Prevalence (12)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Craniopharyngioma | Annual incidence | 1-9 / 1 000 000 | United States | US | Exact |
| Craniopharyngioma | Annual incidence | 1-9 / 1 000 000 | United States | US | Unspecified |
| Craniopharyngioma | Annual incidence | 1-9 / 1 000 000 | United States | US | Exact |
| Craniopharyngioma | Annual incidence | 1-9 / 1 000 000 | Sweden | Not stated | Exact |
| Craniopharyngioma | Annual incidence | 1-9 / 100 000 | Worldwide | Not stated | Exact |
Showing 5 of 12 prevalence observations.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Craniopharyngioma | 54595 | Exact | Orphadata Science knowledge files, Product 1 |
| Craniopharyngioma | 54595 | Exact | Orphanet Rare Disease Ontology (ORDO) |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: sub-conditions in mesh.