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Condition (MeSH)

Neoplasms by Histologic Type

ClinicalTrials.gov lists 43,324 trials for Neoplasms by Histologic Type or a narrower condition beneath it. National Cancer Institute (NCI) has the most among industry and government lead sponsors, with 1,896.

MeSH D009370 Neoplasms Neoplasm C04
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Phase 1 Phase 1 8,264 Phase 1/2 Phase 1/2 4,165 Phase 2 Phase 2 13,221 Phase 2/3 Phase 2/3 532 Phase 3 Phase 3 3,398 Phase 4 Phase 4 759 Not applicable Not applicable 5,385 Observational Observational 7,353 Phase 1 Phase 1 8,264 Phase 1/2 Phase 1/2 4,165 Phase 2 Phase 2 13,221 Phase 2/3 Phase 2/3 532 Phase 3 Phase 3 3,398 Phase 4 Phase 4 759 Not applicable Not applicable 5,385 Observational Observational 7,353

Trials per phase (log scale)

2 more sections with rows

132 of the 43,324 trials are tagged with Neoplasms by Histologic Type itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Neoplasms by Histologic Type trials start? (37)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 120 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational
  • Other (Expanded access, Unknown)

Top of scale: 2,422

1990: 18 trials (Observational 3, Not applicable 2, Phase 3 3, Phase 2/3 1, Phase 2 7, Phase 1 2) 1991: 29 trials (Observational 6, Not applicable 2, Phase 3 3, Phase 2 12, Phase 1 6) 1992: 32 trials (Observational 4, Not applicable 4, Phase 3 11, Phase 2/3 1, Phase 2 9, Phase 1/2 1, Phase 1 2) 1993: 55 trials (Observational 7, Not applicable 4, Phase 4 1, Phase 3 15, Phase 2/3 2, Phase 2 22, Phase 1/2 1, Phase 1 3) 1994: 69 trials (Observational 6, Not applicable 2, Phase 3 24, Phase 2/3 1, Phase 2 27, Phase 1 9) 1995: 115 trials (Observational 13, Not applicable 1, Phase 4 3, Phase 3 28, Phase 2/3 2, Phase 2 41, Phase 1/2 9, Phase 1 18) 1996: 174 trials (Observational 15, Not applicable 4, Phase 4 2, Phase 3 35, Phase 2/3 2, Phase 2 75, Phase 1/2 6, Phase 1 35) 1997: 226 trials (Observational 22, Not applicable 6, Phase 4 1, Phase 3 41, Phase 2/3 1, Phase 2 94, Phase 1/2 19, Phase 1 42) 1998: 337 trials (Observational 24, Not applicable 10, Phase 4 3, Phase 3 51, Phase 2/3 5, Phase 2 164, Phase 1/2 23, Phase 1 57) 1999: 418 trials (Observational 29, Not applicable 18, Phase 4 2, Phase 3 63, Phase 2/3 4, Phase 2 185, Phase 1/2 30, Phase 1 87) 2000: 516 trials (Observational 51, Not applicable 28, Phase 4 8, Phase 3 86, Phase 2/3 6, Phase 2 207, Phase 1/2 50, Phase 1 80) 2001: 486 trials (Observational 40, Not applicable 26, Phase 4 5, Phase 3 56, Phase 2/3 6, Phase 2 217, Phase 1/2 54, Phase 1 82) 2002: 554 trials (Observational 43, Not applicable 28, Phase 4 6, Phase 3 72, Phase 2/3 7, Phase 2 251, Phase 1/2 61, Phase 1 86) 2003: 627 trials (Observational 60, Not applicable 50, Phase 4 19, Phase 3 91, Phase 2/3 7, Phase 2 260, Phase 1/2 57, Phase 1 83) 2004: 850 trials (Observational 82, Not applicable 52, Phase 4 14, Phase 3 85, Phase 2/3 15, Phase 2 378, Phase 1/2 75, Phase 1 149) 2005: 992 trials (Other 1, Observational 99, Not applicable 73, Phase 4 15, Phase 3 94, Phase 2/3 6, Phase 2 432, Phase 1/2 92, Phase 1 180) 2006: 1,095 trials (Other 2, Observational 120, Not applicable 64, Phase 4 18, Phase 3 98, Phase 2/3 18, Phase 2 473, Phase 1/2 113, Phase 1 189) 2007: 1,197 trials (Other 4, Observational 139, Not applicable 89, Phase 4 26, Phase 3 100, Phase 2/3 14, Phase 2 483, Phase 1/2 100, Phase 1 242) 2008: 1,264 trials (Other 1, Observational 210, Not applicable 110, Phase 4 24, Phase 3 98, Phase 2/3 18, Phase 2 460, Phase 1/2 112, Phase 1 231) 2009: 1,292 trials (Other 3, Observational 208, Not applicable 112, Phase 4 22, Phase 3 122, Phase 2/3 18, Phase 2 432, Phase 1/2 124, Phase 1 251) 2010: 1,377 trials (Other 3, Observational 234, Not applicable 117, Phase 4 40, Phase 3 110, Phase 2/3 17, Phase 2 446, Phase 1/2 143, Phase 1 267) 2011: 1,370 trials (Observational 241, Not applicable 132, Phase 4 32, Phase 3 110, Phase 2/3 13, Phase 2 461, Phase 1/2 127, Phase 1 254) 2012: 1,376 trials (Other 1, Observational 227, Not applicable 164, Phase 4 28, Phase 3 112, Phase 2/3 11, Phase 2 432, Phase 1/2 132, Phase 1 269) 2013: 1,324 trials (Observational 207, Not applicable 169, Phase 4 38, Phase 3 103, Phase 2/3 18, Phase 2 381, Phase 1/2 125, Phase 1 283) 2014: 1,467 trials (Observational 234, Not applicable 196, Phase 4 33, Phase 3 112, Phase 2/3 19, Phase 2 387, Phase 1/2 159, Phase 1 327) 2015: 1,618 trials (Other 2, Observational 252, Not applicable 223, Phase 4 46, Phase 3 129, Phase 2/3 22, Phase 2 462, Phase 1/2 173, Phase 1 309) 2016: 1,737 trials (Observational 316, Not applicable 201, Phase 4 41, Phase 3 122, Phase 2/3 22, Phase 2 463, Phase 1/2 198, Phase 1 374) 2017: 1,857 trials (Observational 303, Not applicable 245, Phase 4 27, Phase 3 153, Phase 2/3 19, Phase 2 518, Phase 1/2 227, Phase 1 365) 2018: 1,975 trials (Observational 362, Not applicable 271, Phase 4 24, Phase 3 127, Phase 2/3 30, Phase 2 524, Phase 1/2 218, Phase 1 419) 2019: 2,094 trials (Observational 402, Not applicable 291, Phase 4 49, Phase 3 137, Phase 2/3 26, Phase 2 554, Phase 1/2 209, Phase 1 426) 2020: 2,115 trials (Observational 440, Not applicable 307, Phase 4 28, Phase 3 114, Phase 2/3 20, Phase 2 568, Phase 1/2 194, Phase 1 444) 2021: 2,355 trials (Observational 455, Not applicable 368, Phase 4 29, Phase 3 135, Phase 2/3 24, Phase 2 652, Phase 1/2 230, Phase 1 462) 2022: 2,353 trials (Observational 531, Not applicable 391, Phase 4 37, Phase 3 127, Phase 2/3 25, Phase 2 549, Phase 1/2 227, Phase 1 466) 2023: 2,275 trials (Observational 512, Not applicable 383, Phase 4 34, Phase 3 146, Phase 2/3 22, Phase 2 532, Phase 1/2 237, Phase 1 409) 2024: 2,422 trials (Observational 571, Not applicable 397, Phase 4 33, Phase 3 128, Phase 2/3 28, Phase 2 645, Phase 1/2 185, Phase 1 435) 2025: 2,329 trials (Observational 483, Not applicable 404, Phase 4 37, Phase 3 133, Phase 2/3 39, Phase 2 601, Phase 1/2 217, Phase 1 415)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 2,298
2025 2,329
2024 2,422
2023 2,275
2022 2,353
2021 2,355
2020 2,115
2019 2,094
2018 1,975
2017 1,857

Forecast of the full-year count, planned starts included, not rows of this table: about 2,800 trials starting in 2026 and about 2,500 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 10 percent and ran about 4 percent high against the count later registered; forecasts made before the year began were off by about 25 percent and ran about 15 percent low against the count later registered, and had about 7 percent more error than repeating last year's count. The part-way figures are from forecasts that used a multiple fitted only on earlier years. A stricter check that trains only on older years did not support adding planned starts for conditions of this size: it ran about 6 percent high against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 5,714 trials still running at the 2026-10-09 snapshot; registered median of 38 months across 24,363 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Neoplasms by Histologic Type trials in? (10)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 8,264
Phase 1/2 4,165
Phase 2 13,221
Phase 2/3 532
Phase 3 3,398
Phase 4 759
Not applicable 5,385
Observational 7,353
Expanded access 242
Unknown 5

How many Neoplasms by Histologic Type trials are recruiting? (13)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 1,969
Recruiting 6,557
Enrolling by invitation 201
Active, not recruiting 3,012
Available 60

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Neoplasms by Histologic Type trials? (6)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Cancer Institute (NCI) 1,896
Novartis Pharmaceuticals 468
Children's Oncology Group 362
Pfizer 297
Bristol-Myers Squibb 272

Which drugs are being tested for Neoplasms by Histologic Type? (4)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Cytoxan 1,971
RITUXIMAB 1,222
PEMBROLIZUMAB 975
NIVOLUMAB 752

Interventions as named in the registry (11)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Dexamethasone/Dexamethasone acetate 1,201
SQ Fludarabine 1,098
Cisplatin 1 973
Cytarabine IT 923
Doxorubicine 882

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Neoplasms by Histologic Type trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Pneumonia 18,206 2,005
Febrile neutropenia 15,194 1,698
Pyrexia 10,310 1,574
Sepsis 9,330 2,198
Neutrophil count decreased 8,411 781

Sub-conditions in MeSH (14)

MeSH descendants one level down with at least one trial, most trials first.

+4 more sub-conditions

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: publications, prevalence, and rare-disease identity.

Browse all condition evidence pages