Condition (MeSH)
Cryptococcosis
ClinicalTrials.gov lists 72 trials for Cryptococcosis or a narrower condition beneath it. Pfizer has the most among industry and government lead sponsors, with 12.
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Trials per phase
39 of the 72 trials are tagged with Cryptococcosis itself; the rest are tagged with a narrower condition beneath it.
When did Cryptococcosis trials start? (26)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 6
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2025 | 2 |
| 2024 | 1 |
| 2023 | 4 |
| 2022 | 1 |
| 2021 | 3 |
| 2020 | 3 |
| 2019 | 4 |
| 2018 | 1 |
| 2017 | 2 |
| 2016 | 2 |
Showing 10 of 26 earlier years.
No forecast is made for this condition: it averages 1.8 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 3 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Cryptococcosis trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 4 |
| Phase 1/2 | 2 |
| Phase 2 | 8 |
| Phase 2/3 | 3 |
| Phase 3 | 12 |
| Phase 4 | 7 |
| Not applicable | 21 |
| Observational | 15 |
How many Cryptococcosis trials are recruiting? (7)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 2 |
| Recruiting | 5 |
| Enrolling by invitation | 1 |
| Completed | 45 |
| Terminated | 3 |
Showing 5 of 7 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Cryptococcosis trials? (9)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Pfizer | 12 |
| National Institute of Allergy and Infectious Diseases (NIAID) | 8 |
| Merck Sharp & Dohme LLC | 3 |
| National Hospital for Tropical Diseases, Hanoi, Vietnam | 3 |
| ANRS, Emerging Infectious Diseases | 2 |
Showing 5 of 9 sponsors.
Which drugs are being tested for Cryptococcosis? (5)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| AMPHOTERICIN B | 19 |
| Flucytosine | 11 |
| Itraconazole | 2 |
| Amphotericin B Deoxycholate | 2 |
| Efungumab (Mycograb) | 2 |
Interventions as named in the registry (10)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Fluconazol | 26 |
| Voriconazole 1% | 3 |
| Posaconazole oral suspension | 2 |
| Sertralin | 2 |
| liposomal Amphotericine B | 2 |
Showing 5 of 10 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Cryptococcosis trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Anemia | 110 | 2 |
| Grade 4 Serious AEs | 80 | 1 |
| Grade 3 Serious AEs | 78 | 1 |
| Hyponatremia | 36 | 2 |
| Meningitis cryptococcal | 35 | 2 |
Showing 5 of 10 adverse events.
Which publications cover Cryptococcosis? (43)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Efficacy and safety of isavuconazole against deep-seated mycoses: A phase 3, randomized, open-label study in Japan. | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy | 2023 | Yes |
| Cryptococcosis among hospitalised patients with COVID-19: A multicentre research network study. | Mycoses | 2022 | Yes |
| Prevalence of Advanced HIV Disease, Cryptococcal Antigenemia, and Suboptimal Clinical Outcomes Among Those Enrolled in Care in Vietnam. | Journal of acquired immune deficiency syndromes (1999) | 2021 | Yes |
| Adjunctive sertraline for asymptomatic cryptococcal antigenemia: A randomized clinical trial. | Medical mycology | 2020 | Yes |
| Phase I EnACT Trial of the Safety and Tolerability of a Novel Oral Formulation of Amphotericin B. | Antimicrobial agents and chemotherapy | 2020 | Yes |
Showing 5 of 43 publications.
Prevalence (6)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Cryptococcosis | Point prevalence | Unknown | Worldwide | Not stated | Exact |
| Cryptococcosis | Annual incidence | 1-5 / 10 000 | Europe | Not stated | Exact |
| Cryptococcosis | Point prevalence | Unknown | Worldwide | Not stated | Unspecified |
| Cryptococcosis | Annual incidence | 1-5 / 10 000 | Europe | Not stated | Exact |
| Cryptococcosis | Annual incidence | 1-5 / 10 000 | Europe | Not stated | Unspecified |
Showing 5 of 6 prevalence observations.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Cryptococcosis | 1546 | Exact | Orphanet Rare Disease Ontology (ORDO) |
| Cryptococcosis | 1546 | Exact | Orphadata Science knowledge files, Product 1 |
Sub-conditions in MeSH (1)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.