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Condition (MeSH)

Dental Pulp Diseases

ClinicalTrials.gov lists 485 trials for Dental Pulp Diseases or a narrower condition beneath it.

MeSH D003788 Stomatognathic Diseases C07
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Phase 1 Phase 1 21 Phase 1/2 Phase 1/2 8 Phase 2 Phase 2 19 Phase 2/3 Phase 2/3 20 Phase 3 Phase 3 9 Phase 4 Phase 4 29 Not applicable Not applicable 332 Observational Observational 47 Phase 1 Phase 1 21 Phase 1/2 Phase 1/2 8 Phase 2 Phase 2 19 Phase 2/3 Phase 2/3 20 Phase 3 Phase 3 9 Phase 4 Phase 4 29 Not applicable Not applicable 332 Observational Observational 47

Trials per phase (log scale)

129 of the 485 trials are tagged with Dental Pulp Diseases itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Dental Pulp Diseases trials start? (25)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 2 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 60

1991: 1 trials (Observational 1) 2003: 1 trials (Phase 4 1) 2004: 1 trials (Not applicable 1) 2005: 2 trials (Observational 1, Not applicable 1) 2006: 1 trials (Observational 1) 2007: 3 trials (Observational 1, Phase 3 1, Phase 2 1) 2008: 2 trials (Observational 1, Not applicable 1) 2009: 5 trials (Observational 1, Not applicable 3, Phase 1 1) 2010: 7 trials (Observational 1, Phase 4 1, Phase 2/3 1, Phase 2 2, Phase 1/2 1, Phase 1 1) 2011: 7 trials (Not applicable 3, Phase 4 2, Phase 2/3 1, Phase 1 1) 2012: 4 trials (Not applicable 3, Phase 4 1) 2013: 7 trials (Not applicable 6, Phase 2/3 1) 2014: 11 trials (Observational 2, Not applicable 4, Phase 4 2, Phase 3 1, Phase 2/3 1, Phase 1 1) 2015: 17 trials (Observational 1, Not applicable 12, Phase 4 2, Phase 3 1, Phase 2 1) 2016: 23 trials (Observational 1, Not applicable 17, Phase 4 1, Phase 2/3 2, Phase 2 2) 2017: 30 trials (Observational 2, Not applicable 19, Phase 4 2, Phase 3 1, Phase 2/3 2, Phase 2 3, Phase 1 1) 2018: 35 trials (Observational 2, Not applicable 23, Phase 4 2, Phase 3 2, Phase 2/3 1, Phase 2 4, Phase 1 1) 2019: 35 trials (Observational 1, Not applicable 30, Phase 3 1, Phase 2/3 2, Phase 1 1) 2020: 29 trials (Observational 3, Not applicable 23, Phase 4 2, Phase 1/2 1) 2021: 35 trials (Observational 3, Not applicable 23, Phase 4 5, Phase 2/3 1, Phase 2 1, Phase 1/2 1, Phase 1 1) 2022: 36 trials (Observational 2, Not applicable 24, Phase 4 1, Phase 2/3 3, Phase 2 2, Phase 1/2 2, Phase 1 2) 2023: 43 trials (Observational 1, Not applicable 31, Phase 4 3, Phase 3 1, Phase 2/3 3, Phase 1/2 1, Phase 1 3) 2024: 60 trials (Observational 5, Not applicable 47, Phase 4 2, Phase 3 1, Phase 2/3 1, Phase 2 2, Phase 1/2 1, Phase 1 1) 2025: 52 trials (Observational 11, Not applicable 35, Phase 2/3 1, Phase 2 1, Phase 1 4)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 34
2025 52
2024 60
2023 43
2022 36
2021 35
2020 29
2019 35
2018 35
2017 30

Forecast of the full-year count, planned starts included, not rows of this table: about 44 trials starting in 2026 and about 47 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 33 months from start to primary completion across 26 trials still running at the 2026-10-09 snapshot; registered median of 14 months across 255 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Dental Pulp Diseases trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 21
Phase 1/2 8
Phase 2 19
Phase 2/3 20
Phase 3 9
Phase 4 29
Not applicable 332
Observational 47

How many Dental Pulp Diseases trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 44
Recruiting 39
Enrolling by invitation 5
Active, not recruiting 19
Completed 240

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which drugs are being tested for Dental Pulp Diseases? (1)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Sodium Hypochlorite 10

Interventions as named in the registry (14)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Mineral Trioxide Aggregate 15
Calcium Hydroxide 14
Biodentine 11
MTA 8
Formocresol 5

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Dental Pulp Diseases trials report? (2)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Death of patient 2 1
Death of Patient 1 1

Which publications cover Dental Pulp Diseases? (76)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Effectiveness of diagnosing pulpitis: A systematic review. International endodontic journal 2023 Yes
Modern Endodontic Microsurgery Concepts: A Clinical Update. Dental clinics of North America 2017 Yes
Primary Tooth Vital Pulp Therapy: A Systematic Review and Meta-analysis. Pediatric dentistry 2017 Yes
Pulp Therapy for Primary and Immature Permanent Teeth. Pediatric dentistry 2017 Yes
Guideline on Pulp Therapy for Primary and Immature Permanent Teeth. Pediatric dentistry 2016 Yes

Sub-conditions in MeSH (5)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: lead sponsors, prevalence, and rare-disease identity.

Browse all condition evidence pages