Condition (MeSH)
DiGeorge Syndrome
ClinicalTrials.gov lists 46 trials for DiGeorge Syndrome or a narrower condition beneath it. Sumitomo Pharma Switzerland GmbH has the most among industry and government lead sponsors, with 7.
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Trials per phase
46 of the 46 trials are tagged with DiGeorge Syndrome itself; the rest are tagged with a narrower condition beneath it.
When did DiGeorge Syndrome trials start? (22)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 5
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 3 |
| 2024 | 1 |
| 2023 | 1 |
| 2022 | 1 |
| 2020 | 5 |
| 2018 | 2 |
| 2017 | 2 |
| 2016 | 3 |
| 2015 | 5 |
| 2013 | 2 |
Showing 10 of 22 earlier years.
No forecast is made for this condition: it averages 1.2 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 4 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are DiGeorge Syndrome trials in? (7)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 4 |
| Phase 1/2 | 1 |
| Phase 2 | 8 |
| Phase 3 | 1 |
| Phase 4 | 1 |
| Not applicable | 12 |
| Observational | 19 |
How many DiGeorge Syndrome trials are recruiting? (6)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Recruiting | 9 |
| Enrolling by invitation | 1 |
| Active, not recruiting | 1 |
| Completed | 23 |
| Terminated | 8 |
Showing 5 of 6 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most DiGeorge Syndrome trials? (7)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Sumitomo Pharma Switzerland GmbH | 7 |
| National Center for Research Resources (NCRR) | 2 |
| Progenity, Inc. | 2 |
| Aevi Genomic Medicine, LLC, a Cerecor company | 1 |
| Bausch Health Americas, Inc. | 1 |
Showing 5 of 7 sponsors.
Interventions as named in the registry (15)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Cultured Thymus Tissue for Implantation (CTTI) | 2 |
| Hematopoietic Stem Cell Transplant | 1 |
| Calcium Chloride/Calcium Gluconate | 1 |
| Rabbit Anti thymocyte globulin | 1 |
| PTH 1-34 | 1 |
Showing 5 of 15 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do DiGeorge Syndrome trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Device related infection | 39 | 4 |
| Pyrexia | 16 | 4 |
| Respiratory failure | 15 | 4 |
| Hypoxia | 10 | 4 |
| Diarrhoea | 7 | 5 |
Showing 5 of 10 adverse events.
Which publications cover DiGeorge Syndrome? (40)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| First Prenatal Case of Genotypically and Phenotypically Overlapping Double Molecular Diagnosis of Van den Ende-Gupta and 22q11.2 Deletion Syndromes. | Molecular genetics & genomic medicine | 2025 | Yes |
| Extent of magnitude representation deficit and relationship with arithmetic skills in children with 22q11.2DS. | Orphanet journal of rare diseases | 2024 | Yes |
| Speech Telepractice and Treatment Intensity in a Cantonese-Speaking Case with 22q11.2 Deletion Syndrome Following Late Diagnosis and Management of Velopharyngeal Dysfunction. | The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association | 2023 | Yes |
| Experience with cultured thymus tissue in 105 children. | The Journal of allergy and clinical immunology | 2022 | Yes |
| Cell-free DNA screening for prenatal detection of 22q11.2 deletion syndrome. | American journal of obstetrics and gynecology | 2022 | Yes |
Showing 5 of 40 publications.
Prevalence (12)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| 22q11.2 deletion syndrome | Prevalence at birth | 1-5 / 10 000 | United States | US | Exact |
| 22q11.2 deletion syndrome | Prevalence at birth | 1-5 / 10 000 | United States | US | Exact |
| 22q11.2 deletion syndrome | Point prevalence | Unknown | Worldwide | Not stated | Exact |
| 22q11.2 deletion syndrome | Prevalence at birth | 1-5 / 10 000 | Worldwide | Not stated | Exact |
| 22q11.2 deletion syndrome | Prevalence at birth | 1-5 / 10 000 | France | Not stated | Exact |
Showing 5 of 12 prevalence observations.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| 22q11.2 deletion syndrome | 567 | Exact | Orphadata Science knowledge files, Product 1 |
| 22q11.2 deletion syndrome | 567 | Exact | Orphanet Rare Disease Ontology (ORDO) |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: sub-conditions in mesh.