Condition (MeSH)
Dupuytren Contracture
ClinicalTrials.gov lists 75 trials for Dupuytren Contracture or a narrower condition beneath it. Endo USA Inc., a Keenova Therapeutics Company has the most among industry and government lead sponsors, with 10.
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Trials per phase (log scale)
75 of the 75 trials are tagged with Dupuytren Contracture itself; the rest are tagged with a narrower condition beneath it.
When did Dupuytren Contracture trials start? (23)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 8
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 5 |
| 2025 | 2 |
| 2024 | 8 |
| 2023 | 3 |
| 2022 | 2 |
| 2021 | 3 |
| 2020 | 1 |
| 2019 | 4 |
| 2018 | 3 |
| 2017 | 6 |
Showing 10 of 23 earlier years.
No forecast is made for this condition: it averages 3.6 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 36 months from start to primary completion across 8 trials still running at the 2026-10-09 snapshot; registered median of 24 months across 43 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Dupuytren Contracture trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 1 |
| Phase 1/2 | 1 |
| Phase 2 | 7 |
| Phase 2/3 | 1 |
| Phase 3 | 12 |
| Phase 4 | 11 |
| Not applicable | 24 |
| Observational | 18 |
How many Dupuytren Contracture trials are recruiting? (7)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 5 |
| Recruiting | 12 |
| Active, not recruiting | 3 |
| Completed | 41 |
| Terminated | 2 |
Showing 5 of 7 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Dupuytren Contracture trials? (3)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Endo USA Inc., a Keenova Therapeutics Company | 10 |
| Asahi Kasei Therapeutics Corporation | 1 |
| CONNEXT | 1 |
Interventions as named in the registry (15)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Clostridium Histolyticum Collagenase | 11 |
| Xiapex | 6 |
| Radiation Therapy | 2 |
| Collagenase | 2 |
| NAC 0mg/day (Placebo) | 1 |
Showing 5 of 15 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Dupuytren Contracture trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Tendon rupture | 5 | 4 |
| Cataract | 3 | 1 |
| Pain in extremity | 3 | 3 |
| Cerebrovascular accident | 2 | 1 |
| Colon cancer | 2 | 2 |
Showing 5 of 10 adverse events.
Which publications cover Dupuytren Contracture? (62)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Surgery, Needle Fasciotomy, or Collagenase Injection for Dupuytren Contracture : A Randomized Controlled Trial. | Annals of internal medicine | 2024 | Yes |
| Limited fasciectomy with versus without autologous adipose tissue grafting for treatment of Dupuytren's contracture (REMEDY): study protocol for a multicentre randomised controlled trial. | Trials | 2024 | Yes |
| Adjuvant steroid to percutaneous needle fasciotomy for Dupuytren's contracture. An RCT study protocol. | Danish medical journal | 2024 | Yes |
| The deep fascia and its role in chronic pain and pathological conditions: A review. | Clinical anatomy (New York, N.Y.) | 2022 | Yes |
| Focused electromagnetic high-energetic extracorporeal shockwave (ESWT) reduces pain levels in the nodular state of Dupuytren's disease-a randomized controlled trial (DupuyShock). | Lasers in medical science | 2022 | Yes |
Showing 5 of 62 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.