Condition (MeSH)
Empyema
ClinicalTrials.gov lists 57 trials for Empyema or a narrower condition beneath it.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase (log scale)
34 of the 57 trials are tagged with Empyema itself; the rest are tagged with a narrower condition beneath it.
When did Empyema trials start? (23)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 5
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 4 |
| 2025 | 2 |
| 2024 | 5 |
| 2023 | 2 |
| 2022 | 4 |
| 2021 | 5 |
| 2020 | 3 |
| 2019 | 4 |
| 2018 | 4 |
| 2017 | 2 |
Showing 10 of 23 earlier years.
No forecast is made for this condition: it averages 3.4 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 36 months from start to primary completion across 6 trials still running at the 2026-10-09 snapshot; registered median of 24 months across 30 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Empyema trials in? (7)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 3 |
| Phase 2/3 | 2 |
| Phase 3 | 7 |
| Phase 4 | 8 |
| Not applicable | 22 |
| Observational | 14 |
How many Empyema trials are recruiting? (6)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 4 |
| Recruiting | 6 |
| Completed | 28 |
| Terminated | 2 |
| Withdrawn | 1 |
Showing 5 of 6 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which drugs are being tested for Empyema? (1)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Urokinase | 2 |
Interventions as named in the registry (14)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| insertion of a chest drain with urokinase instillation | 2 |
| Intrapleural Medications | 2 |
| Alteplase t-PA | 2 |
| antibiotic concentration in pleural fluid | 1 |
| Conservative Arm | 1 |
Showing 5 of 14 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Empyema trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Serious bleeding | 6 | 1 |
| Bronchopleural fistula | 2 | 1 |
| Hemothorax | 2 | 1 |
| Low hemoglobin levels | 2 | 1 |
| Pneumothorax | 2 | 2 |
Showing 5 of 10 adverse events.
Which publications cover Empyema? (27)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Medical and Surgical Management of Empyema. | Seminars in respiratory and critical care medicine | 2019 | Yes |
| To drain or not to drain? Predictors of tube thoracostomy insertion and outcomes associated with drainage of traumatic hemothoraces. | Injury | 2015 | Yes |
| Surgical stabilization of severe rib fractures decreases incidence of retained hemothorax and empyema. | American journal of surgery | 2015 | Yes |
| Increased paediatric hospitalizations for empyema in Australia after introduction of the 7-valent pneumococcal conjugate vaccine. | Bulletin of the World Health Organization | 2013 | Yes |
| Microbiological diagnosis of empyema in children: comparative evaluations by culture, polymerase chain reaction, and pneumococcal antigen detection in pleural fluids. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America | 2006 | Yes |
Showing 5 of 27 publications.
Sub-conditions in MeSH (1)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: lead sponsors, prevalence, and rare-disease identity.