Condition (MeSH)
Empyema, Pleural
ClinicalTrials.gov lists 32 trials for Empyema, Pleural or a narrower condition beneath it.
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Trials per phase
32 of the 32 trials are tagged with Empyema, Pleural itself; the rest are tagged with a narrower condition beneath it.
When did Empyema, Pleural trials start? (16)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 4
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 3 |
| 2025 | 2 |
| 2024 | 4 |
| 2023 | 1 |
| 2022 | 4 |
| 2021 | 4 |
| 2020 | 3 |
| 2019 | 1 |
| 2018 | 3 |
| 2015 | 1 |
Showing 10 of 16 earlier years.
No forecast is made for this condition: it averages 2.8 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 36 months from start to primary completion across 6 trials still running at the 2026-10-09 snapshot; registered median of 24 months across 17 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Empyema, Pleural trials in? (6)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 2 | 2 |
| Phase 2/3 | 1 |
| Phase 3 | 3 |
| Phase 4 | 6 |
| Not applicable | 13 |
| Observational | 7 |
How many Empyema, Pleural trials are recruiting? (5)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 2 |
| Recruiting | 5 |
| Completed | 15 |
| Terminated | 1 |
| Unknown status | 9 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Interventions as named in the registry (15)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Intrapleural Medications | 2 |
| insertion of a chest drain with urokinase instillation | 1 |
| Conservative Arm | 1 |
| Fibrinolytic Therapy | 1 |
| Levofloxacin + clindamycin | 1 |
Showing 5 of 15 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Empyema, Pleural trials report? (9)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Serious bleeding | 6 | 1 |
| Bronchopleural fistula | 2 | 1 |
| Hemothorax | 2 | 1 |
| Low hemoglobin levels | 2 | 1 |
| altered mental state | 2 | 1 |
Showing 5 of 9 adverse events.
Which publications cover Empyema, Pleural? (72)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Modified regimen intrapleural alteplase with pulmozyme in pleural infection management: a tertiary teaching hospital experience. | BMC pulmonary medicine | 2022 | Yes |
| Intrapleural fibrinolysis and DNase versus video-assisted thoracic surgery (VATS) for the treatment of pleural empyema (FIVERVATS): protocol for a randomised, controlled trial - surgery as first-line treatment. | BMJ open | 2022 | Yes |
| Oral Lactobacillus fermentum CECT5716 in the patients with lactational abscess treated by needle aspiration: The late follow-up of a randomized controlled trial. | Medicine | 2022 | Yes |
| Medical management of pleural infection: Why not saline intrapleural lavage? | The clinical respiratory journal | 2022 | Yes |
| Epidemiology of pleural empyema in English hospitals and the impact of influenza. | The European respiratory journal | 2021 | Yes |
Showing 5 of 72 publications.
Prevalence (3)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Pleural empyema | Point prevalence | 1-5 / 10 000 | Europe | Not stated | Unspecified |
| Pleural empyema | Point prevalence | 1-5 / 10 000 | Europe | Not stated | Exact |
| Pleural empyema | Point prevalence | 1-5 / 10 000 | Europe | Not stated | Exact |
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Pleural empyema | 449266 | Exact | Orphadata Science knowledge files, Product 1 |
| Pleural empyema | 449266 | Exact | Orphanet Rare Disease Ontology (ORDO) |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: lead sponsors and sub-conditions in mesh.