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Condition (MeSH)

Facial Nerve Diseases

ClinicalTrials.gov lists 285 trials for Facial Nerve Diseases or a narrower condition beneath it. Biogen has the most among industry and government lead sponsors, with 6.

MeSH D005155 Stomatognathic Diseases C07 C10
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Phase 1 Phase 1 17 Phase 1/2 Phase 1/2 7 Phase 2 Phase 2 13 Phase 2/3 Phase 2/3 5 Phase 3 Phase 3 8 Phase 4 Phase 4 17 Not applicable Not applicable 150 Observational Observational 68 Phase 1 Phase 1 17 Phase 1/2 Phase 1/2 7 Phase 2 Phase 2 13 Phase 2/3 Phase 2/3 5 Phase 3 Phase 3 8 Phase 4 Phase 4 17 Not applicable Not applicable 150 Observational Observational 68

Trials per phase (log scale)

5 of the 285 trials are tagged with Facial Nerve Diseases itself; the rest are tagged with a narrower condition beneath it.

Get the Facial Nerve Diseases report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Facial Nerve Diseases trials start? (28)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 31

1997: 1 trials (Phase 2 1) 1998: 2 trials (Not applicable 2) 2001: 1 trials (Phase 4 1) 2002: 1 trials (Observational 1) 2003: 1 trials (Not applicable 1) 2004: 1 trials (Observational 1) 2005: 2 trials (Observational 1, Not applicable 1) 2006: 3 trials (Not applicable 2, Phase 2/3 1) 2007: 4 trials (Observational 2, Not applicable 1, Phase 2/3 1) 2008: 6 trials (Observational 2, Not applicable 2, Phase 3 1, Phase 1/2 1) 2009: 4 trials (Observational 2, Not applicable 2) 2010: 3 trials (Not applicable 2, Phase 4 1) 2011: 3 trials (Not applicable 2, Phase 4 1) 2012: 9 trials (Observational 5, Not applicable 2, Phase 4 1, Phase 2 1) 2013: 2 trials (Observational 1, Not applicable 1) 2014: 5 trials (Observational 1, Not applicable 2, Phase 2/3 1, Phase 2 1) 2015: 10 trials (Observational 3, Not applicable 3, Phase 2 1, Phase 1 3) 2016: 16 trials (Observational 5, Not applicable 6, Phase 1/2 2, Phase 1 3) 2017: 6 trials (Observational 1, Not applicable 2, Phase 4 2, Phase 3 1) 2018: 14 trials (Observational 5, Not applicable 7, Phase 4 1, Phase 2/3 1) 2019: 18 trials (Observational 3, Not applicable 7, Phase 4 2, Phase 3 2, Phase 2 3, Phase 1 1) 2020: 17 trials (Observational 3, Not applicable 10, Phase 4 2, Phase 1 2) 2021: 25 trials (Observational 6, Not applicable 16, Phase 4 2, Phase 1 1) 2022: 23 trials (Observational 10, Not applicable 8, Phase 2/3 1, Phase 2 1, Phase 1/2 1, Phase 1 2) 2023: 26 trials (Observational 3, Not applicable 16, Phase 3 3, Phase 2 1, Phase 1/2 1, Phase 1 2) 2024: 29 trials (Observational 2, Not applicable 19, Phase 4 2, Phase 2 3, Phase 1/2 1, Phase 1 2) 2025: 31 trials (Observational 6, Not applicable 20, Phase 4 2, Phase 3 1, Phase 2 1, Phase 1 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 22
2025 31
2024 29
2023 26
2022 23
2021 25
2020 17
2019 18
2018 14
2017 6

Forecast of the full-year count, planned starts included, not rows of this table: about 30 trials starting in 2026 and about 30 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 32 trials still running at the 2026-10-09 snapshot; registered median of 20 months across 148 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Facial Nerve Diseases trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 17
Phase 1/2 7
Phase 2 13
Phase 2/3 5
Phase 3 8
Phase 4 17
Not applicable 150
Observational 68

How many Facial Nerve Diseases trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 27
Recruiting 37
Enrolling by invitation 4
Active, not recruiting 10
Completed 126

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Facial Nerve Diseases trials? (2)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Biogen 6
Neurotrigger Ltd 3

Which drugs are being tested for Facial Nerve Diseases? (3)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Carbamazepine 8
BIIB074 5
PREDNISOLONE 3

Interventions as named in the registry (12)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
type A botulinum toxin 8
Low Level Laser Therapy 6
Acupuncture 3
Lamotrigine use 3
Observational 3

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Facial Nerve Diseases trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
MALARIA 98 1
PNEUMONIA 61 1
VOMITING 32 1
DEATH 27 1
GASTROENTERITIS 13 1

Which publications cover Facial Nerve Diseases? (9)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Tissue-engineered nerve guides with mesenchymal stem cells in the facial nerve regeneration. Neurochemistry international 2021 Yes
Hearing and facial function outcomes for neurofibromatosis 2 clinical trials. Neurology 2013 Yes
Facial Nerve Grading System 2.0. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2009 Yes
Management of neuropathic orofacial pain. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 2007 Yes
Pathophysiology of hemifacial spasm: I. Ephaptic transmission and ectopic excitation. Neurology 1984 Yes

Sub-conditions in MeSH (7)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages