Condition (MeSH)
Fractures, Closed
ClinicalTrials.gov lists 33 trials for Fractures, Closed or a narrower condition beneath it. Cast21 has the most among industry and government lead sponsors, with 1.
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Trials per phase
33 of the 33 trials are tagged with Fractures, Closed itself; the rest are tagged with a narrower condition beneath it.
When did Fractures, Closed trials start? (13)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 2
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 5
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 1 |
| 2024 | 4 |
| 2021 | 3 |
| 2019 | 4 |
| 2018 | 5 |
| 2016 | 1 |
| 2015 | 2 |
| 2013 | 1 |
| 2012 | 1 |
| 2009 | 1 |
Showing 10 of 13 earlier years.
No forecast is made for this condition: it averages 1.2 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 2 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Fractures, Closed trials in? (6)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 1 |
| Phase 3 | 1 |
| Phase 4 | 5 |
| Not applicable | 18 |
| Observational | 7 |
How many Fractures, Closed trials are recruiting? (6)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Recruiting | 1 |
| Active, not recruiting | 1 |
| Completed | 17 |
| Terminated | 8 |
| Withdrawn | 1 |
Showing 5 of 6 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Fractures, Closed trials? (1)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Cast21 | 1 |
Which drugs are being tested for Fractures, Closed? (4)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| PMI-150 (intranasal ketamine) | 2 |
| Oxycodone | 1 |
| Remifentanil | 1 |
| FENTANYL | 1 |
Interventions as named in the registry (11)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| CEZ, cefazolin sodium | 2 |
| Intranasal Ketamine | 1 |
| Ropivacaine 2 % | 1 |
| Vancomycin 1.1% | 1 |
| Standard Care | 1 |
Showing 5 of 11 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Fractures, Closed trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Infections | 20 | 1 |
| General disorders including death | 9 | 1 |
| Urinary tract infection | 3 | 1 |
| death | 3 | 1 |
| implant problems | 3 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Fractures, Closed? (89)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Management of Hardware-Exposed Soft Tissue Defects Using Dermal Substitutes and Negative Pressure Wound Therapy. | Annals of plastic surgery | 2023 | Yes |
| Outcomes After Operative Treatment of Pediatric Monteggia Fracture-Dislocations: Comparison Between Open and Closed Injuries. | Journal of pediatric orthopedics | 2022 | Yes |
| Cognitive Behavioural Therapy to Optimize Post-Operative Fracture Recovery (COPE): protocol for a randomized controlled trial. | Trials | 2022 | Yes |
| Epidemiology of open tibia fractures in a population-based database: update on current risk factors and clinical implications. | European journal of trauma and emergency surgery : official publication of the European Trauma Society | 2019 | Yes |
| Ultrasound Assessment of Muscle Injury Associated with Closed Limb Fracture. | BioMed research international | 2019 | Yes |
Showing 5 of 89 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.